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  1. Due to the prominent role of the liver in the body and detoxification, its functionality can be affected in an irreversible manner by diseases. This phenomenon renders the liver to stop working, leading to mor...

    Authors: Afsoon Afshari, Sara Shamdani, Georges Uzan, Sina Naserian and Negar Azarpira
    Citation: Stem Cell Research & Therapy 2020 11:54
  2. The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect ...

    Authors: Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales and Xavier Navarro
    Citation: Stem Cell Research & Therapy 2020 11:53
  3. Antibody production after allogeneic administration of mesenchymal stem cells (MSCs) could impact their clinical application. Proinflammatory priming of MSCs can potentiate their regulatory ability in vivo but...

    Authors: Laura Barrachina, Alina Cequier, Antonio Romero, Arantza Vitoria, Pilar Zaragoza, Francisco José Vázquez and Clementina Rodellar
    Citation: Stem Cell Research & Therapy 2020 11:52
  4. Tissue expansion techniques play an important role in plastic surgery. How to improve the quality of the expanded skin and shorten the expansion period are still worth investigating. Our previous studies found...

    Authors: Mingwu Deng, Xiangsheng Wang, Ziyou Yu, Yizuo Cai, Wei Liu, Guangdong Zhou, Xiansong Wang, Zheyuan Yu, Wei Li and Wen Jie Zhang
    Citation: Stem Cell Research & Therapy 2020 11:50
  5. Umbilical cord-derived mesenchymal stem cell (UCMSCs) transplantation has been widely studied in premature ovarian failure (POF). However, the underlying mechanism remains elusive. This study aims to investiga...

    Authors: Na Yin, Chenting Wu, Jianping Qiu, Yueming Zhang, Le Bo, Ying Xu, Mengdie Shi, Songyue Zhu, Guangzhao Yang and Caiping Mao
    Citation: Stem Cell Research & Therapy 2020 11:49
  6. Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in systemic lupus erythematosus patien...

    Authors: Tianbiao Zhou, Chunling Liao, Hong-Yan Li, Wenshan Lin, Shujun Lin and Hongzhen Zhong
    Citation: Stem Cell Research & Therapy 2020 11:48
  7. Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. Additionally, absence of robust methods for ...

    Authors: Fabio Michelet, Aishwarya Balasankar, Nickolas Teo, Lawrence W. Stanton and Shweta Singhal
    Citation: Stem Cell Research & Therapy 2020 11:47
  8. The mesenchymal stem cell (MSC) secretome, via the combined actions of its plethora of biologically active factors, is capable of orchestrating the regenerative responses of numerous tissues by both eliciting ...

    Authors: Dinesh Parate, Nurul Dinah Kadir, Cenk Celik, Eng Hin Lee, James H. P. Hui, Alfredo Franco-Obregón and Zheng Yang
    Citation: Stem Cell Research & Therapy 2020 11:46
  9. Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we h...

    Authors: Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati and Armin Attar
    Citation: Stem Cell Research & Therapy 2020 11:45
  10. Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how int...

    Authors: Sung Yong Ahn, Yong-Sun Maeng, Yu Rim Kim, Young Ho Choe, Han Sung Hwang and Young-Min Hyun
    Citation: Stem Cell Research & Therapy 2020 11:44
  11. Cerebral palsy (CP) is a syndrome of childhood movement and posture disorders. Clinical evidence is still limited and sometimes inconclusive about the benefits of human umbilical cord mesenchymal stem cells (h...

    Authors: Jiaowei Gu, Li Huang, Che Zhang, Yong Wang, Ruibo Zhang, Ziliang Tu, Hengdong Wang, Xihui Zhou, Zhousheng Xiao, Zegan Liu, Xiang Hu, Zunchen Ke, Dabin Wang and Li Liu
    Citation: Stem Cell Research & Therapy 2020 11:43
  12. Evidence has demonstrated conditioned medium (CM) from periodontal ligament stem cells (PDLSCs) improved periodontal regeneration. Gingival mesenchymal stem cells (GMSCs) have been considered an alternative st...

    Authors: Jiling Qiu, Xiaotong Wang, Haowen Zhou, Chunshu Zhang, Yijia Wang, Jiahui Huang, Meng Liu, Pishan Yang and Aimei Song
    Citation: Stem Cell Research & Therapy 2020 11:42
  13. Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is i...

    Authors: Wen Wang, Changyong Yuan, Tengyu Geng, Yi Liu, Shaoyue Zhu, Chengfei Zhang, Zongxiang Liu and Penglai Wang
    Citation: Stem Cell Research & Therapy 2020 11:40
  14. Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diab...

    Authors: Shichang Zhang, Li Chen, Guoying Zhang and Bo Zhang
    Citation: Stem Cell Research & Therapy 2020 11:39
  15. As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchym...

    Authors: Lu Zhang, Guangjun Jiao, Shanwu Ren, Xiaoqian Zhang, Ci Li, Wenliang Wu, Hongliang Wang, Haichun Liu, Hongming Zhou and Yunzhen Chen
    Citation: Stem Cell Research & Therapy 2020 11:38
  16. Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we previously reported that peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) strongly suppresses the acti...

    Authors: Mingyang Shao, Qing Xu, Zhenru Wu, Yuwei Chen, Yuke Shu, Xiaoyue Cao, Menglin Chen, Bo Zhang, Yongjie Zhou, Rong Yao, Yujun Shi and Hong Bu
    Citation: Stem Cell Research & Therapy 2020 11:37
  17. A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. The present study aims to explore how ...

    Authors: Zhuzhi Wen, Zun Mai, Xiaolin Zhu, Tao Wu, Yangxin Chen, Dengfeng Geng and Jingfeng Wang
    Citation: Stem Cell Research & Therapy 2020 11:36
  18. Adipose-derived stem cell (ASC) expansion under atmospheric oxygen levels (21%) was previously shown to cause increased reactive oxygen species (ROS) accumulation and genetic instability compared to cells cult...

    Authors: Gal Tirza, Inna Solodeev, Meirav Sela, Ilanit Greenberg, Metsada Pasmanik-Chor, Eyal Gur and Nir Shani
    Citation: Stem Cell Research & Therapy 2020 11:35
  19. Vascularization is important for the clinical application of tissue engineered products. Both adipose-derived stem cells (ASCs) and surgical prefabrication can be used to induce angiogenesis in scaffolds. Our ...

    Authors: Tomasz Dębski, Agata Kurzyk, Barbara Ostrowska, Juliusz Wysocki, Jakub Jaroszewicz, Wojciech Święszkowski and Zygmunt Pojda
    Citation: Stem Cell Research & Therapy 2020 11:34
  20. The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d & 5e are mistakenly mixed-up.

    Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou
    Citation: Stem Cell Research & Therapy 2020 11:33

    The original article was published in Stem Cell Research & Therapy 2019 10:30

  21. Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth fa...

    Authors: Catriona J. Cunningham, Raymond Wong, Jack Barrington, Sabrina Tamburrano, Emmanuel Pinteaux and Stuart M. Allan
    Citation: Stem Cell Research & Therapy 2020 11:32
  22. Extracellular vesicles, especially exosomes, have emerged as key mediators of intercellular communication with the potential to improve cardiac function as part of cell-based therapies. We previously demonstra...

    Authors: Hanbin Chen, Wenzheng Xia and Meng Hou
    Citation: Stem Cell Research & Therapy 2020 11:31

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:376

  23. Preeclampsia is a common obstetric syndrome affecting women in their first pregnancy and characterized by hypertension and proteinuria, which appears after 20 weeks of gestation. It is characterized by high bl...

    Authors: Yasser S. Basmaeil, Dana Algudiri, Reem Alenzi, Abdullah Al Subayyil, Ayodele Alaiya and Tanvir Khatlani
    Citation: Stem Cell Research & Therapy 2020 11:30
  24. Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing. Therefore, in clinical practice, post-culture MSC supernatant treatm...

    Authors: Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczyńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka and Aleksandra Klimczak
    Citation: Stem Cell Research & Therapy 2020 11:29
  25. Endothelial progenitor cells (EPCs) contribute to reendothelialization and neovascularization and protect against vascular injury and ischemia of various organs. We have previously shown downregulation of micr...

    Authors: Chong Zhe Pei, Bo Liu, Ye Ting Li, Lu Fang, Yi Zhang, Yi Gang Li and Shu Meng
    Citation: Stem Cell Research & Therapy 2020 11:28
  26. Vitiligo is an acquired chronic and recurrent skin disease that causes a depigmentation disorder, resulting in selective destruction of melanocytes (MC). However, the mechanism that leads to melanocyte dysfunc...

    Authors: Lifei Zhu, Xi Lin, Lin Zhi, Yushan Fang, Keming Lin, Kai Li and Liangcai Wu
    Citation: Stem Cell Research & Therapy 2020 11:26
  27. Mesenchymal stem cells (MSCs) are a population of pluripotent cells that might be used for treatment of liver disease. However, the efficacy of MSCs for mice with alcoholic hepatitis (AH) and its underlying me...

    Authors: Yue-Meng Wan, Zhi-qiang Li, Qiong Zhou, Chang Liu, Men-Jie Wang, Hui-Xin Wu, Yun-Zhen Mu, Yue-Feng He, Yuan Zhang, Xi-Nan Wu, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Jin-Hui Yang and Xiao-Fang Wang
    Citation: Stem Cell Research & Therapy 2020 11:24
  28. Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells an...

    Authors: Mingzhuo Lin, Xinyue Liu, Haoxiao Zheng, Xiaohui Huang, Yu Wu, Anqing Huang, Hailan Zhu, Yunzhao Hu, Weiyi Mai and Yuli Huang
    Citation: Stem Cell Research & Therapy 2020 11:22
  29. Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous vesicles release...

    Authors: Liyang Dong, Yanan Pu, Xiaojun Chen, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang and Chuan Su
    Citation: Stem Cell Research & Therapy 2020 11:21
  30. Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and s...

    Authors: Rui Guo, Masatoshi Morimatsu, Tian Feng, Feng Lan, Dehua Chang, Feng Wan and Yunpeng Ling
    Citation: Stem Cell Research & Therapy 2020 11:19
  31. Profound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients. Currently, no ideal treatment exists to i...

    Authors: Yusef Yousuf, Andrea Datu, Ben Barnes, Saeid Amini-Nik and Marc G. Jeschke
    Citation: Stem Cell Research & Therapy 2020 11:18
  32. Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neu...

    Authors: Atul Malhotra, Margie Castillo-Melendez, Beth J. Allison, Amy E. Sutherland, Ilias Nitsos, Yen Pham, Courtney A. McDonald, Michael C. Fahey, Graeme R. Polglase, Graham Jenkin and Suzanne L. Miller
    Citation: Stem Cell Research & Therapy 2020 11:17
  33. Toll-like receptor 4 (TLR4) ligands such as lipopolysaccharide (LPS) activate immunomodulatory functions and the migration of human mesenchymal stromal cells (hMSCs). Here, we study the migration-related gene ...

    Authors: Sun Hwa Kim, Hae In Choi, Mi Ran Choi, Ga Yeong An, Bert Binas, Kyoung Hwa Jung and Young Gyu Chai
    Citation: Stem Cell Research & Therapy 2020 11:16
  34. In Asherman’s syndrome (AS), intrauterine scarring and fibrotic adhesions lead to menstrual disorders, pregnancy loss, or infertility. A few clinical trials have piloted cell therapy to overcome AS. Understand...

    Authors: Suzanna Queckbörner, Elisabeth Syk Lundberg, Kristina Gemzell-Danielsson and Lindsay C. Davies
    Citation: Stem Cell Research & Therapy 2020 11:15
  35. Persistent epithelial defects (PED), associated with limbal stem cell deficiency (LSCD), require ocular surface reconstruction with a stable corneal epithelium (CE). This study investigated CE reformation usin...

    Authors: Francisco Bandeira, Tze-Wei Goh, Melina Setiawan, Gary Hin-Fai Yam and Jodhbir S. Mehta
    Citation: Stem Cell Research & Therapy 2020 11:14
  36. This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added.

    Authors: Juan Fafián-Labora, Miriam Morente-López, María José Sánchez-Dopico, Onno J. Arntz, Fons A. J. van de Loo, Javier De Toro and María C. Arufe
    Citation: Stem Cell Research & Therapy 2020 11:13
  37. Osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is regulated by numerous signaling pathways. Dopamine (DA), a neurotransmitter, has previously been demonstrated to induce new bone formation b...

    Authors: Chen-Xi Wang, Xi-Yuan Ge, Ming-Yue Wang, Ting Ma, Yu Zhang and Ye Lin
    Citation: Stem Cell Research & Therapy 2020 11:12
  38. To explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potent...

    Authors: Lu Zhai, Yuhua Liu, Wenpiao Zhao, Qingyun Chen, Tao Guo, Wei Wei, Zhuchun Luo, Yanfeng Huang, Cui Ma, Feng Huang and Xia Dai
    Citation: Stem Cell Research & Therapy 2020 11:10

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:513

  39. The recent concept of secretome-based tissue regeneration has profoundly altered the field of regenerative medicine and offers promising novel therapeutic options. In contrast to medicinal products with a sing...

    Authors: Maria Laggner, Alfred Gugerell, Christiane Bachmann, Helmut Hofbauer, Vera Vorstandlechner, Marcus Seibold, Ghazaleh Gouya Lechner, Anja Peterbauer, Sibylle Madlener, Svitlana Demyanets, Dirk Sorgenfrey, Tobias Ostler, Michael Erb, Michael Mildner and Hendrik Jan Ankersmit
    Citation: Stem Cell Research & Therapy 2020 11:9
  40. Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently take...

    Authors: Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop and Decio L. Eizirik
    Citation: Stem Cell Research & Therapy 2020 11:7
  41. Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by ...

    Authors: Neety Sahu, Gaurav Budhiraja and Anuradha Subramanian
    Citation: Stem Cell Research & Therapy 2020 11:6
  42. Periodontal ligament stromal cells (PDLSCs) are ideal cell sources for periodontal tissue repair and regeneration, but little is known about what determines their osteogenic capacity. Long non-coding RNAs (lnc...

    Authors: Yiping Huang, Yineng Han, Runzhi Guo, Hao Liu, Xiaobei Li, Lingfei Jia, Yunfei Zheng and Weiran Li
    Citation: Stem Cell Research & Therapy 2020 11:5
  43. Progressive loss of cell functionality caused by an age-related impairment in cell metabolism concerns not only mature specialized cells but also its progenitors, which significantly reduces their regenerative...

    Authors: Michalina Alicka, Katarzyna Kornicka-Garbowska, Katarzyna Kucharczyk, Martyna Kępska, Michael Rӧcken and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2020 11:4
  44. Premature ovarian failure (POF) has a great impact on reproductive endocrine function in females, and it is an important cause of infertility. Previous studies have demonstrated that small extracellular vesicl...

    Authors: Mengyu Liu, Yu Qiu, Zhuowei Xue, Ruoyu Wu, Jie Li, Xin Niu, Ji Yuan, Yang Wang and Qingkai Wu
    Citation: Stem Cell Research & Therapy 2020 11:3

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:276

  45. ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in the airway injury model, and liraglutide, glucagon-lik...

    Authors: Yun Feng, Linlin Wang, Xiaoying Ma, Xiaotong Yang, Ocholi Don, Xiaoyan Chen, Jieming Qu and Yuanlin Song
    Citation: Stem Cell Research & Therapy 2020 11:2
  46. Human placenta-derived mesenchymal stem cells (PD-MSCs) are powerful sources for cell therapy in regenerative medicine. However, a limited lifespan by senescence through mechanisms that are well unknown is the...

    Authors: Jin Seok, Hyun Sook Jung, Sohae Park, Jung Ok Lee, Chong Jai Kim and Gi Jin Kim
    Citation: Stem Cell Research & Therapy 2020 11:1

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