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  1. Although the involvement of glycoprotein non-metastatic melanomal protein B (GPNMB) in regulating the odontogenic differentiation of human dental pulp stem cells (hDPCs) has been identified, the underlying mec...

    Authors: Fengxi Liu, Xin Wang, Yun Yang, Rongrong Hu, Wenhao Wang and Yuliang Wang
    Citation: Stem Cell Research & Therapy 2019 10:35
    Content type: Research Published on:

  2. The original article [1] contains a duplication error within Figure 3.

    Authors: Kang Chao, Shenghong Zhang, Yun Qiu, Xiaoyong Chen, Xiaoran Zhang, Chuang Cai, Yanwen Peng, Ren Mao, Meirav Pevsner-Fischer, Shomron Ben-horin, Eran Elinav, Zhirong Zeng, Baili Chen, Yao He, Andy Peng Xiang and Minhu Chen
    Citation: Stem Cell Research & Therapy 2019 10:33
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2016 7:109

  3. Ell3 is a RNA polymerase II elongation factor that has various cell type-dependent functions, such as regulating the differentiation efficiency of embryonic stem cells and sensitizing cancer cells to anticance...

    Authors: Jae-Yong Lee, Soo-Hong Lee, Kwang-Soo Kim, Keun-Hong Park and Kyung-Soon Park
    Citation: Stem Cell Research & Therapy 2019 10:32
    Content type: Research Published on:

  4. Fully understanding the developmental process of hepatic stem cells (HSCs) and the mechanisms of their committed differentiation is essential for optimizing the generation of functional hepatocytes for cell th...

    Authors: Jiefang Huang, Xiaonan Zhao, Jian Wang, Yiji Cheng, Qiong Wu, Bei Wang, Fang Zhao, Lijun Meng, Yanyun Zhang, Min Jin and Huanbai Xu
    Citation: Stem Cell Research & Therapy 2019 10:31
    Content type: Research Published on:

  5. Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone is one of the most commonly damaged tissues. Damage to bone marrow mesenchymal stem cells (BM-MSCs) induced by ra...

    Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou
    Citation: Stem Cell Research & Therapy 2019 10:30
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:33

  6. Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this st...

    Authors: Simona Ruggieri, Luigi Viggiano, Tiziana Annese, Carmela Rubolino, Andrea Gerbino, Roberta De Zio, Patrizia Corsi, Roberto Tamma, Domenico Ribatti, Mariella Errede, Francesca Operto, Lucia Margari, Nicoletta Resta, Silvia Di Tommaso, Jessica Rosati, Maria Trojano…
    Citation: Stem Cell Research & Therapy 2019 10:29
    Content type: Short report Published on:

  7. Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by OCT4. p21, a gene negatively associated with self-re...

    Authors: Yan Lu, Huinan Qu, Da Qi, Wenhong Xu, Shutong Liu, Xiangshu Jin, Peiye Song, Yantong Guo, Yiyang Jia, Xinqi Wang, Hairi Li, Yulin Li and Chengshi Quan
    Citation: Stem Cell Research & Therapy 2019 10:28
    Content type: Research Published on:

  8. Patients with diabetes mellitus (DM) often suffered with many musculoskeletal disorders, such as tendon rupture and tendinopathy. However, the understanding of the pathogenesis of these alternations is limited...

    Authors: Liu SHI, Ying-juan LI, Guang-chun DAI, Yu-cheng LIN, Gang LI, Chen WANG, Hui CHEN and Yun-feng RUI
    Citation: Stem Cell Research & Therapy 2019 10:27
    Content type: Research Published on:

  9. Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Her...

    Authors: Cajsa Davegårdh, Elin Hall Wedin, Christa Broholm, Tora Ida Henriksen, Maria Pedersen, Bente Klarlund Pedersen, Camilla Scheele and Charlotte Ling
    Citation: Stem Cell Research & Therapy 2019 10:26
    Content type: Research Published on:

  10. Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research e...

    Authors: Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson and Alicia J. El Haj
    Citation: Stem Cell Research & Therapy 2019 10:25
    Content type: Research Published on:

  12. The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood.

    Authors: Alexandra Calle, Soraya López-Martín, Marta Monguió-Tortajada, Francesc Enric Borràs, María Yáñez-Mó and Miguel Ángel Ramírez
    Citation: Stem Cell Research & Therapy 2019 10:23
    Content type: Research Published on:

  13. Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important. Human liver stem cells (HLSCs) are early undifferentiated cells that...

    Authors: Yanzhen Bi, Jiannan Li, Yonghong Yang, Quanyi Wang, Quanquan Wang, Xiaobei Zhang, Guanjun Dong, Yibo Wang, Zhongping Duan, Zhenfeng Shu, Tongjun Liu, Yu Chen, Kai Zhang and Feng Hong
    Citation: Stem Cell Research & Therapy 2019 10:22
    Content type: Research Published on:

  14. Until now, there is no effective anti-fibrotic therapy available for liver cirrhosis. Stem cell therapies have been studied for the treatment of hepatic fibrosis. However, the use of embryonic stem cells or in...

    Authors: Suhyun Park, Seon In Hwang, Jonghun Kim, Seoyeon Hwang, Sohee Kang, Sera Yang, Jonghwa Kim, Wonseok Kang, Kyun-Hwan Kim, Dong Wook Han and Yong-Han Paik
    Citation: Stem Cell Research & Therapy 2019 10:21
    Content type: Research Published on:

  15. Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese m...

    Authors: Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun and Xiaobo Sun
    Citation: Stem Cell Research & Therapy 2019 10:20
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:310

  16. Mesenchymal stem cells (MSCs) have emerged as a promising regenerative tool, owing mainly to their multi-differentiation potential and immunosuppressive capacity. When compared with MSCs classically derived fr...

    Authors: Jiao Ma, Jun Wu, Lei Han, Xiangxiang Jiang, Long Yan, Jie Hao and Hongmei Wang
    Citation: Stem Cell Research & Therapy 2019 10:19
    Content type: Research Published on:

  17. Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary dependi...

    Authors: Xiaolei Li, Bingxue Shang, Ya-nan Li, Yufang Shi and Changshun Shao
    Citation: Stem Cell Research & Therapy 2019 10:18
    Content type: Research Published on:

  18. Cell therapy remains the most promising approach against ischemic heart injury. However, poor survival of engrafted cells in ischemic sites diminishes its therapeutic efficacy. Follistatin-like 1 (Fstl1) is do...

    Authors: Han Shen, Guanghao Cui, Yanqiong Li, Wenxue Ye, Yimin Sun, Zihan Zhang, Jingjing Li, Guiying Xu, Xiansheng Zeng, Yanxia Zhang, Wencheng Zhang, Zan Huang, Weiqian Chen and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2019 10:17
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:47

  19. Liver fibrosis is a key phase that will progress to further injuries such as liver cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone marrow mesenchymal stromal cells (BM-M...

    Authors: Xiao-Yu Luo, Xiang-Jun Meng, Da-Chun Cao, Wei Wang, Kun Zhou, Lei Li, Mei Guo and Ping Wang
    Citation: Stem Cell Research & Therapy 2019 10:16
    Content type: Research Published on:

  20. Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach a...

    Authors: Tianyue Pan, Hao Liu, Yuan Fang, Zheng Wei, Shiyang Gu, Gang Fang, Yifan Liu, Yang Luo, Daqiao Guo, Xin Xu, Bin Chen, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi…
    Citation: Stem Cell Research & Therapy 2019 10:15
    Content type: Research Published on:

  21. Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibrodysplasia ossificans progressiva (FOP), is a serious condition without effective treatment. Understanding of the core process of...

    Authors: Chen Kan, Na Ding, Jiazhao Yang, Zhenya Tan, Tammy L. McGuire, Haimei Lu, Keqin Zhang, Diana M. Palila Berger, John A. Kessler and Lixin Kan
    Citation: Stem Cell Research & Therapy 2019 10:14
    Content type: Research Published on:

  23. Distraction osteogenesis (DO) is an effective but lengthy procedure to fully induce bone regeneration in large bone defects. Accumulating evidence supports the role of exosomes secreted by endothelial progenit...

    Authors: Yachao Jia, Yu Zhu, Shuo Qiu, Jia Xu and Yimin Chai
    Citation: Stem Cell Research & Therapy 2019 10:12
    Content type: Research Published on:

  24. Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity. Yet, their scarcity, limited expansion...

    Authors: Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer and Giuseppe Maria de Peppo
    Citation: Stem Cell Research & Therapy 2019 10:11
    Content type: Research Published on:

  25. Although mesenchymal stem/stromal cell (MSC) chondrogenic differentiation has been thoroughly investigated, the rudiments for enhancing chondrogenesis have remained largely dependent on external cues. Focus to...

    Authors: Melika Sarem, Oliver Otto, Simon Tanaka and V. Prasad Shastri
    Citation: Stem Cell Research & Therapy 2019 10:10
    Content type: Research Published on:

  26. Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6...

    Authors: Peng Xu, Ting-ting Wang, Xiu-zhen Liu, Nan-Yu Wang, Li-hong Sun, Zhu-qin Zhang, Hou-zao Chen, Xiang Lv, Yue Huang and De-Pei Liu
    Citation: Stem Cell Research & Therapy 2019 10:9
    Content type: Research Published on:

  28. The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research interest. A renewable source of brown adipocyte (BA) proge...

    Authors: Michael D. West, Ching-Fang Chang, Dana Larocca, Jie Li, Jianjie Jiang, Pamela Sim, Ivan Labat, Karen B. Chapman, Kari E. Wong, James Nicoll, Michael J. Van Kanegan, Aubrey D. N. J. de Grey, Igor O. Nasonkin, Andreas Stahl and Hal Sternberg
    Citation: Stem Cell Research & Therapy 2019 10:7
    Content type: Research Published on:

  29. The original article [1] contained errors in the presentation of Figure 7.

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang
    Citation: Stem Cell Research & Therapy 2019 10:6
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:339

  30. The etiology and pathology osteonecrosis of the femoral head (ONFH) are not completely clarified. As a cytokine participating in systemic inflammation, tumor necrosis factor alpha (TNFα) has been shown to be i...

    Authors: Bin Fang, Ding Wang, Jiaqian Zheng, Qiushi Wei, Dongxiang Zhan, Yamei Liu, Xuesong Yang, Haibin Wang, Gang Li, Wei He and Liangliang Xu
    Citation: Stem Cell Research & Therapy 2019 10:5
    Content type: Research Published on:

  31. To explore the effect of mesenchymal stem cells isolated from menstrual blood (MB-MSCs) on epirubicin-induced damage to human ovarian granulosa cells (GCs) and its potential mechanisms.

    Authors: Zhongrui Yan, Fengyi Guo, Qing Yuan, Yu Shao, Yedan Zhang, Huiyan Wang, Shaohua Hao and Xue Du
    Citation: Stem Cell Research & Therapy 2019 10:4
    Content type: Research Published on:

  32. Hertwig’s epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial–mesenchymal transition (EMT) and inducing odontoblastic differentia...

    Authors: Xuebing Li, Sicheng Zhang, Zirui Zhang, Weihua Guo, Guoqing Chen and Weidong Tian
    Citation: Stem Cell Research & Therapy 2019 10:3
    Content type: Research Published on:

  33. Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged ...

    Authors: Tsung-Chuan Ho, Shawn H. Tsai, Shu-I Yeh, Show-Li Chen, Kwang-Yi Tung, Hsin-Yu Chien, Yung-Chang Lu, Chang-Hung Huang and Yeou-Ping Tsao
    Citation: Stem Cell Research & Therapy 2019 10:2
    Content type: Research Published on:

  35. Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical applica...

    Authors: Fei Zhang, Yuan Xie and Yuhao Bian
    Citation: Stem Cell Research & Therapy 2018 9:358
    Content type: Research Published on:

  36. Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention. In this study, we simulated...

    Authors: Juryun Kim, Yena Kim, Jinhyeok Choi, Hyerin Jung, Kijun Lee, Jaewoo Kang, Narae Park, Yeri Alice Rim, Yoojun Nam and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2018 9:357
    Content type: Research Published on:

  37. Bone marrow mesenchymal stem cells (BMSCs) can provide an additional source of therapeutic stem cells for regeneration of liver cells during acute liver injury (ALI). However, the insufficient hepatic homing b...

    Authors: Ting Sun, Feng Gao, Xin Li, Yingyu Cai, Min Bai, Fan Li and Lianfang Du
    Citation: Stem Cell Research & Therapy 2018 9:356
    Content type: Research Published on:

  38. Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are considered attractive sources of pancreatic β cells and islet organoids. Recently, several reports presented that hESC/iPSC-deri...

    Authors: Hussain Md. Shahjalal, Ahmed Abdal Dayem, Kyung Min Lim, Tak-il Jeon and Ssang-Goo Cho
    Citation: Stem Cell Research & Therapy 2018 9:355
    Content type: Review Published on:

  39. This article [1] has been retracted by the authors because, contrary to the statement in the article, ethical approval was not obtained to conduct this study.

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim
    Citation: Stem Cell Research & Therapy 2018 9:354
    Content type: Retraction Note Published on:

    The original article was published in Stem Cell Research & Therapy 2014 5:54

  40. A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in th...

    Authors: Haiyan Min, Jianwei Yang, Sanbin Wang, Pengfei Tao, Yuqin Song, Xiaopei Wang, Huiqin Li, Xinping Yang, Xingqi Dong, Fu-Sheng Wang, Ming Shi, Xicheng Wang and Ruonan Xu
    Citation: Stem Cell Research & Therapy 2018 9:353
    Content type: Short report Published on:

  41. Adipose tissue is an excellent source for isolation of stem cells for treating various clinical conditions including injuries to the neuromuscular system. Many previous studies have focused on differentiating ...

    Authors: R. El-Habta, M. Sloniecka, P. J. Kingham and L. J. Backman
    Citation: Stem Cell Research & Therapy 2018 9:352
    Content type: Research Published on:

  42. Human bone marrow-derived mesenchymal stem/stromal cells (hBM MSCs) have multiple functions, critical for skeletal formation and function. Their functional heterogeneity, however, represents a major challenge ...

    Authors: Alison T. Merryweather-Clarke, David Cook, Barbara Joo Lara, Peng Hua, Emmanouela Repapi, Neil Ashley, Shiang Y. Lim and Suzanne M. Watt
    Citation: Stem Cell Research & Therapy 2018 9:351
    Content type: Research Published on:

  43. Ischemic vascular diseases are the major cause of death worldwide. In recent years, endothelial cell (EC)-based approaches to vascular regeneration are increasingly viable strategies for treating ischemic dise...

    Authors: Fuyi Cheng, Yujing Zhang, Yuan Wang, Qingyuan Jiang, Cheng jian Zhao, Jie Deng, Xiaolei Chen, Yunqi Yao, Zhemin Xia, Lin Cheng, Lei Dai, Gang Shi, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei…
    Citation: Stem Cell Research & Therapy 2018 9:350
    Content type: Research Published on:

  44. The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that ag...

    Authors: Rodolfo G. Goya, Marianne Lehmann, Priscila Chiavellini, Martina Canatelli-Mallat, Claudia B. Hereñú and Oscar A. Brown
    Citation: Stem Cell Research & Therapy 2018 9:349
    Content type: Review Published on:

  45. This study was aimed to investigate the role and specific molecular mechanism of HIF1A-AS2/miR-665/IL6 axis in regulating osteogenic differentiation of adipose-derived stem cells (ASCs) via the PI3K/Akt signal...

    Authors: Ruoyu Wu, Jihao Ruan, Yongjin Sun, Mengyu Liu, Zhuang Sha, Cunyi Fan and Qingkai Wu
    Citation: Stem Cell Research & Therapy 2018 9:348
    Content type: Research Published on:

  47. Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underl...

    Authors: Caixia Jin, Qingjian Ou, Zongyi Li, Juan Wang, Jieping Zhang, Haibin Tian, Jing-Ying Xu, Furong Gao, Lixia Lu and Guo-Tong Xu
    Citation: Stem Cell Research & Therapy 2018 9:346
    Content type: Research Published on:

  48. Basic fibroblast growth factor (bFGF) regulates maintenance of stemness and modulation of osteo/odontogenic differentiation and mineralization in stem cells from human exfoliated deciduous teeth (SHEDs). Miner...

    Authors: Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Brian L. Foster and Thanaphum Osathanon
    Citation: Stem Cell Research & Therapy 2018 9:345
    Content type: Research Published on:

  49. Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy fo...

    Authors: Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung and Hsin-Fu Chen
    Citation: Stem Cell Research & Therapy 2018 9:344
    Content type: Research Published on:

  50. Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells fr...

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2018 9:340
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:446

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