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  1. Type 2 diabetes (T2D) is closely associated with liver fibrosis, but no effective treatments are currently available. This study was designed to investigate the therapeutic effects of ADSCs on insulin resistan...

    Authors: Naishun Liao, Youshi Zheng, Haihua Xie, Bixing Zhao, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu
    Citation: Stem Cell Research & Therapy 2017 8:286
    Content type: Research Published on:

  2. Human amnion-derived mesenchymal stem cells (hAD-MSCs) have the features of mesenchymal stem cells (MSCs). Low-intensity pulsed ultrasound (LIPUS) can promote the expression of various growth factors and anti-...

    Authors: Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Wenqian Zhang, Lianli He, Ziling Wang, Qianru Zeng and Zhengai Xiong
    Citation: Stem Cell Research & Therapy 2017 8:283
    Content type: Research Published on:

  3. Strontium is a widely used anti-osteoporotic agent due to its dual effects on inhibiting bone resorption and stimulating bone formation. Thus, we studied the dose response of strontium on osteo-inductive effic...

    Authors: Abudousaimi Aimaiti, Asihaerjiang Maimaitiyiming, Xu Boyong, Kaisaier Aji, Cao Li and Lei Cui
    Citation: Stem Cell Research & Therapy 2017 8:282
    Content type: Research Published on:

  4. Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays a key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs). However, the way in which it affects the ...

    Authors: Peng Xia, Xiaoju Wang, Yanping Qu, Qiang Lin, Kai Cheng, Mingxia Gao, Shasha Ren, Tingting Zhang and Xueping Li
    Citation: Stem Cell Research & Therapy 2017 8:281
    Content type: Research Published on:

  5. The stiffness of the myocardial extracellular matrix (ECM) and the transplanted cell type are vitally important in promoting angiogenesis. However, the combined effect of the two factors remains uncertain. The...

    Authors: Shuning Zhang, Xin Ma, Junjie Guo, Kang Yao, Cong Wang, Zhen Dong, Hong Zhu, Fan Fan, Zheyong Huang, Xiangdong Yang, Juying Qian, Yunzeng Zou, Aijun Sun and Junbo Ge
    Citation: Stem Cell Research & Therapy 2017 8:280
    Content type: Research Published on:

  6. Although previous reports have revealed the therapeutic potential of stem cell transplantation in diabetic polyneuropathy, the effects of cell transplantation on long-term diabetic polyneuropathy have not been...

    Authors: Maiko Omi, Masaki Hata, Nobuhisa Nakamura, Megumi Miyabe, Shogo Ozawa, Hitoshi Nukada, Masami Tsukamoto, Kazunori Sango, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Jun Takebe, Tatsuaki Matsubara and Keiko Naruse
    Citation: Stem Cell Research & Therapy 2017 8:279
    Content type: Research Published on:

  7. The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS i...

    Authors: Jiehua Wu, Susan Shimmon, Sharon Paton, Christopher Daly, Tony Goldschlager, Stan Gronthos, Andrew C. W. Zannettino and Peter Ghosh
    Citation: Stem Cell Research & Therapy 2017 8:278
    Content type: Research Published on:

  8. Mesenchymal stem cells (MSCs) are capable of immunomodulation and tissue regeneration, highlighting their potential translational application for treating inflammatory bone disorders. MSC-mediated immunomodula...

    Authors: Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao and Stuart B. Goodman
    Citation: Stem Cell Research & Therapy 2017 8:277
    Content type: Research Published on:

  9. Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown. This st...

    Authors: Jin-Sun Lee, EunJi Kim, Seonggu Han, Kyung Lhi Kang and Jung Sun Heo
    Citation: Stem Cell Research & Therapy 2017 8:276
    Content type: Research Published on:

  10. Mesenchymal stem cells (MSCs) possess intrinsic regeneration capacity as part of the repair process in response to injury, such as fracture or other tissue injury. Bone marrow and adipose tissue are the major ...

    Authors: Liangliang Xu, Yamei Liu, Yuxin Sun, Bin Wang, Yunpu Xiong, Weiping Lin, Qiushi Wei, Haibin Wang, Wei He, Bin Wang and Gang Li
    Citation: Stem Cell Research & Therapy 2017 8:275
    Content type: Research Published on:

  11. We aimed to evaluate the potential enhancing effect of celastrol on the stemness of human tendon-derived stem cells (hTSCs) in vitro and the underlying molecular mechanisms.

    Authors: Tianyi Wu, Shenghe Liu, Gen Wen, Jia Xu, Yaling Yu and Yimin Chai
    Citation: Stem Cell Research & Therapy 2017 8:274
    Content type: Research Published on:

  12. Novel therapies are urgently needed to address the rising incidence and prevalence of acute kidney injury (AKI) and chronic kidney disease (CKD). Mesenchymal stem/stromal cells (MSCs) have shown promising resu...

    Authors: Arash Aghajani Nargesi, Lilach O. Lerman and Alfonso Eirin
    Citation: Stem Cell Research & Therapy 2017 8:273
    Content type: Review Published on:

  14. Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease...

    Authors: Elvira Parrotta, Maria Teresa De Angelis, Stefania Scalise, Patrizio Candeloro, Gianluca Santamaria, Mariagrazia Paonessa, Maria Laura Coluccio, Gerardo Perozziello, Stefania De Vitis, Antonella Sgura, Elisa Coluzzi, Vincenzo Mollace, Enzo Mario Di Fabrizio and Giovanni Cuda
    Citation: Stem Cell Research & Therapy 2017 8:271
    Content type: Research Published on:

  15. Human amniotic epithelial cells (hAECs) are attractive candidates for regenerative medical therapy, with the potential to replace deficient cells and improve functional recovery after injury. Previous studies ...

    Authors: Qiuwan Zhang, Shixia Bu, Junyan Sun, Minhua Xu, Xiaofen Yao, Kunyan He and Dongmei Lai
    Citation: Stem Cell Research & Therapy 2017 8:270
    Content type: Research Published on:

  16. Titanium surfaces have been modified by various approaches with the aim of improving the stimulation of osseointegration. Laser beam (Yb-YAG) treatment is a controllable and flexible approach to modifying surf...

    Authors: Tatiana A. B. Bressel, Jana Dara Freires de Queiroz, Susana Margarida Gomes Moreira, Jéssyca T. da Fonseca, Edson A. Filho, Antônio Carlos Guastaldi and Silvia Regina Batistuzzo de Medeiros
    Citation: Stem Cell Research & Therapy 2017 8:269
    Content type: Research Published on:

  17. Our study aim was to evaluate the therapeutic efficacy and mechanisms of miR-133-overexpressing mesenchymal stem cells (MSCs) on acute myocardial infarction.

    Authors: Yueqiu Chen, Yunfeng Zhao, Weiqian Chen, Lincen Xie, Zhen-Ao Zhao, Junjie Yang, Yihuan Chen, Wei Lei and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2017 8:268
    Content type: Research Published on:

  18. Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drug...

    Authors: Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu and Yuqing Chen
    Citation: Stem Cell Research & Therapy 2017 8:267
    Content type: Research Published on:

  19. This study aimed to investigate the tolerogenic mechanisms induced by semimature dendritic cells (smDCs) and regulatory dendritic cells (regDCs) after transplantation of hepatocytes differentiated from mouse e...

    Authors: Cheng Zhang, Wenwei Liao, Bing Cai, Furong Liu, Qiong Ke, Xiaofeng Zhu, Xiaoshun He and Anbin Hu
    Citation: Stem Cell Research & Therapy 2017 8:266
    Content type: Research Published on:

  20. Osteoinduction and subsequent bone formation rely on efficient mesenchymal stem cell (MSC) recruitment. It is also known that migration is induced by gradients of growth factors and cytokines. Degradation of Ca2+

    Authors: Rubén Aquino-Martínez, Alcira P. Angelo and Francesc Ventura Pujol
    Citation: Stem Cell Research & Therapy 2017 8:265
    Content type: Research Published on:

  21. Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. T...

    Authors: Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen, Xiaoyuan Gong, Weinan Zeng, Liu Yang and Cheng Chen
    Citation: Stem Cell Research & Therapy 2017 8:264
    Content type: Research Published on:

  22. Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HS...

    Authors: Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao and Yubin Kang
    Citation: Stem Cell Research & Therapy 2017 8:263
    Content type: Research Published on:

  23. Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage...

    Authors: Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E. Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee and In-Bo Han
    Citation: Stem Cell Research & Therapy 2017 8:262
    Content type: Research Published on:

  24. Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that ...

    Authors: Philippe Foubert, Diana Zafra, Mike Liu, Rohit Rajoria, Damian Gutierrez, Mayer Tenenhaus and John K. Fraser
    Citation: Stem Cell Research & Therapy 2017 8:261
    Content type: Research Published on:

  25. We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane.

    Authors: Jialin Chen, Wei Zhang, Peyman Kelk, Ludvig J. Backman and Patrik Danielson
    Citation: Stem Cell Research & Therapy 2017 8:260
    Content type: Research Published on:

  26. Administration of bone marrow mononuclear cells (BMMCs) modulates lung inflammation and fibrosis in experimental silicosis. However, no studies have evaluated whether silicosis affects the efficacy of autologo...

    Authors: Helena D’Anunciação de Oliveira, Elga Bernardo Bandeira de Melo, Johnatas Dutra Silva, Jamil Zola Kitoko, Bianca Gutfilen, Thiago Barboza, Sergio Augusto Lopes de Souza, Christina Maeda Takiya, Patricia Rieken Macedo Rocco, Miquéias Lopes-Pacheco and Marcelo Marcos Morales
    Citation: Stem Cell Research & Therapy 2017 8:259
    Content type: Research Published on:

  27. The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor ...

    Authors: Moyuan Deng, Tieniu Mei, Tianyong Hou, Keyu Luo, Fei Luo, Aijun Yang, Bo Yu, Hao Pang, Shiwu Dong and Jianzhong Xu
    Citation: Stem Cell Research & Therapy 2017 8:258
    Content type: Research Published on:

  28. Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small ...

    Authors: Dandan Zhu, Jean Tan, Amina S. Maleken, Ruth Muljadi, Siow T. Chan, Sin N. Lau, Kirstin Elgass, Bryan Leaw, Joanne Mockler, Daniel Chambers, Kristen T. Leeman, Carla F. Kim, Euan M. Wallace and Rebecca Lim
    Citation: Stem Cell Research & Therapy 2017 8:257
    Content type: Research Published on:

  29. Limbal epithelial stem cells (LESCs) play important roles in corneal epithelial homeostasis and regeneration, and damage to the limbus will lead to limbal stem cell deficiency (LSCD), with conjunctivalization ...

    Authors: Yijian Li, Yuli Yang, Lei Yang, Yuxiao Zeng, Xiaowei Gao and Haiwei Xu
    Citation: Stem Cell Research & Therapy 2017 8:256
    Content type: Research Published on:

  30. Several studies have suggested that caffeic acid phenethyl ester (CAPE) can induce the expression of hypoxia inducible factor-1α (HIF-1α) protein. We determined whether CAPE has a novel function in improving t...

    Authors: Xiaofang Chen, Yi Han, Bowen Zhang, Yiming Liu, Sihan Wang, Tuling Liao, Ziliang Deng, Zeng Fan, Jing Zhang, Lijuan He, Wen Yue, Yanhua Li and Xuetao Pei
    Citation: Stem Cell Research & Therapy 2017 8:255
    Content type: Research Published on:

  31. Mesenchymal stem cells (MSCs) play different roles in modulating tumor progression, growth, and metastasis. MSCs are recruited to the tumor site in large numbers and subsequently have an important microenviron...

    Authors: Ahmed El-Badawy, Mohamed A. Ghoneim, Mahmoud M. Gabr, Radwa Ayman Salah, Ihab K. Mohamed, Marwa Amer and Nagwa El-Badri
    Citation: Stem Cell Research & Therapy 2017 8:254
    Content type: Research Published on:

  32. The adult brain is unable to regenerate itself sufficiently after large injuries. Therefore, hopes rely on therapies using neural stem cell or biomaterial transplantation to sustain brain reconstruction. The a...

    Authors: Carole Davoust, Benjamin Plas, Amélie Béduer, Boris Demain, Anne-Sophie Salabert, Jean Christophe Sol, Christophe Vieu, Laurence Vaysse and Isabelle Loubinoux
    Citation: Stem Cell Research & Therapy 2017 8:253
    Content type: Research Published on:

  33. Bi-potential hepatic progenitor cells can give rise to both hepatocytes and cholangiocytes, which is the last phase and critical juncture in terms of sequentially hepatic lineage restriction from any kind of s...

    Authors: Haiyun Pei, Chao Zhai, Huilin Li, Fang Yan, Jinhua Qin, Hongfeng Yuan, Rui Zhang, Shuyong Wang, Wencheng Zhang, Mingyang Chang, Yunfang Wang and Xuetao Pei
    Citation: Stem Cell Research & Therapy 2017 8:252
    Content type: Research Published on:

  34. Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain and infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that...

    Authors: Zongwen Liang, Yijie Chen, Yuan Zhao, Chaoyi Xu, Anqi Zhang, Qiong Zhang, Danhan Wang, Jing He, Wenfeng Hua and Ping Duan
    Citation: Stem Cell Research & Therapy 2017 8:251
    Content type: Research Published on:

  35. Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASC...

    Authors: Juan R. Acosta, Simon Joost, Kasper Karlsson, Anna Ehrlund, Xidan Li, Myriam Aouadi, Maria Kasper, Peter Arner, Mikael Rydén and Jurga Laurencikiene
    Citation: Stem Cell Research & Therapy 2017 8:250
    Content type: Short report Published on:

  37. Transplantation of neural stem cells (NSCs) has been proposed as a promising therapeutic strategy for the treatment of ischemia/reperfusion (I/R)-induced brain injury. However, existing evidence has also chall...

    Authors: Tingting Zhang, Xiao Yang, Tengyuan Liu, Jiaxiang Shao, Ningzhen Fu, Aijuan Yan, Keyi Geng and Weiliang Xia
    Citation: Stem Cell Research & Therapy 2017 8:248
    Content type: Research Published on:

  38. Development of clinical-grade cell preparations is central to meeting the regulatory requirements for cellular therapies under good manufacturing practice-compliant (cGMP) conditions. Since addition of animal ...

    Authors: Athina Bakopoulou, Danae Apatzidou, Eleni Aggelidou, Evangelia Gousopoulou, Gabriele Leyhausen, Joachim Volk, Aristeidis Kritis, Petros Koidis and Werner Geurtsen
    Citation: Stem Cell Research & Therapy 2017 8:247
    Content type: Research Published on:

  39. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) are a novel and promising strategy for tissue engineering because of their ability to differentiate into many cell types. We characterized the different...

    Authors: Qin Shi, JingWei Gao, Yao Jiang, Baolan Sun, Wei Lu, Min Su, Yunzhao Xu, Xiaoqing Yang and Yuquan Zhang
    Citation: Stem Cell Research & Therapy 2017 8:246
    Content type: Research Published on:

  40. Because the lack of an induced pluripotent stem cell (iPSC) induction system with optimal safety and efficiency limits the application of these cells, development of such a system is important.

    Authors: Linli Wang, Yuehua Chen, Chunyan Guan, Zhiju Zhao, Qiang Li, Jianguo Yang, Jian Mo, Bin Wang, Wei Wu, Xiaohui Yang, Libing Song and Jun Li
    Citation: Stem Cell Research & Therapy 2017 8:245
    Content type: Research Published on:

  41. Induced pluripotent stem cells (iPSC) provide an unlimited patient-specific cell source for regenerative medicine. Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from dono...

    Authors: Jieun Lee, Piera Smeriglio, Constance R. Chu and Nidhi Bhutani
    Citation: Stem Cell Research & Therapy 2017 8:244
    Content type: Research Published on:

  42. Mesenchymal stromal cells (MSCs) can be used intra-articularly to quell inflammation and promote cartilage healing; however, mechanisms by which MSCs mitigate joint disease remain poorly understood. Galectins,...

    Authors: Heidi L. Reesink, Ryan M. Sutton, Carolyn R. Shurer, Ryan P. Peterson, Julie S. Tan, Jin Su, Matthew J. Paszek and Alan J. Nixon
    Citation: Stem Cell Research & Therapy 2017 8:243
    Content type: Research Published on:

  43. Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for...

    Authors: Chi Miao, Mingming Lei, Weina Hu, Shuo Han and Qi Wang
    Citation: Stem Cell Research & Therapy 2017 8:242
    Content type: Review Published on:

  44. Insulin resistance is one of the most common and important pathological features of type 2 diabetes (T2D). Recently, insulin resistance is increasingly considered to be associated with systemic chronic inflamm...

    Authors: Xiaoya Sun, Haojie Hao, Qingwang Han, Xiaoyan Song, Jiejie Liu, Liang Dong, Weidong Han and Yiming Mu
    Citation: Stem Cell Research & Therapy 2017 8:241
    Content type: Research Published on:

  45. Transcription factors regulate gene expression through binding to specific enhancer sequences. Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma onc...

    Authors: Yaxi Zhu, Qian Liu, Zhiguang Zhou and Yasuhiro Ikeda
    Citation: Stem Cell Research & Therapy 2017 8:240
    Content type: Review Published on:

  46. Degenerative diseases are a major public health concern for the aging population and mesenchymal stem cells (MSCs) have great potential for treating many of these diseases. However, the quantity and quality of...

    Authors: Travis J. Block, Milos Marinkovic, Olivia N. Tran, Aaron O. Gonzalez, Amanda Marshall, David D. Dean and Xiao-Dong Chen
    Citation: Stem Cell Research & Therapy 2017 8:239
    Content type: Research Published on:

  47. For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, tre...

    Authors: Santiago Roura, Carolina Gálvez-Montón, Clémentine Mirabel, Joaquim Vives and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2017 8:238
    Content type: Review Published on:

  48. Endothelial progenitor cell (EPC) differentiation is considered crucial for vascular repair. Vascular endothelial growth factor (VEGF) induces EPC differentiation, but the underlying mechanism of this phenomen...

    Authors: Lufeng Li, Huanyun Liu, Chunxin Xu, Mengyang Deng, Mingbao Song, Xuejun Yu, Shangcheng Xu and Xiaohui Zhao
    Citation: Stem Cell Research & Therapy 2017 8:237
    Content type: Research Published on:

  49. The use of stem cells, including mesenchymal stem cells (MSCs), for regenerative medicine is gaining interest for the clinical benefits so far obtained in patients. This study investigates the use of adipose a...

    Authors: Francesco Virzì, Paola Bianca, Alessandro Giammona, Tiziana Apuzzo, Simone Di Franco, Laura Rosa Mangiapane, Maria Luisa Colorito, Dario Catalano, Emanuela Scavo, Annalisa Nicotra, Antonina Benfante, Giuseppe Pistone, Valentina Caputo, Francesco Dieli, Roberto Pirrello and Giorgio Stassi
    Citation: Stem Cell Research & Therapy 2017 8:236
    Content type: Research Published on:

  50. Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cell...

    Authors: Samantha C. Fisch, María L. Gimeno, Julia D. Phan, Ariel A. Simerman, Daniel A. Dumesic, Marcelo J. Perone and Gregorio D. Chazenbalk
    Citation: Stem Cell Research & Therapy 2017 8:227
    Content type: Review Published on:
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