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  1. Long-term ventricular pacing has deleterious effects and becomes more significant when cumulative percent ventricular pacing (Cum%VP) exceeds 40% of time. However, cellular disturbances and pathways by which p...

    Authors: Chang Cui, Le Geng, Jiaojiao Shi, Yue Zhu, Gang Yang, Zidun Wang, Jiaxian Wang and Minglong Chen
    Citation: Stem Cell Research & Therapy 2017 8:109
  2. The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells, such as nucleus pulpos...

    Authors: Kang Lu, Hai-yin Li, Kuang Yang, Jun-long Wu, Xiao-wei Cai, Yue Zhou and Chang-qing Li
    Citation: Stem Cell Research & Therapy 2017 8:108
  3. Interstitial cystitis (IC) is a chronic inflammation disorder mainly within the submucosal and muscular layers of the bladder. As the cause of IC remains unknown, no effective treatments are currently availabl...

    Authors: Jia Li, Hui Luo, Xingyou Dong, Qian Liu, Chao Wu, Teng Zhang, Xiaoyan Hu, Yuanyuan Zhang, Bo Song and Longkun Li
    Citation: Stem Cell Research & Therapy 2017 8:107
  4. Microcarrier cultures which are useful for producing large cell numbers can act as scaffolds to create stem cell-laden microcarrier constructs for cartilage tissue engineering. However, the critical attributes...

    Authors: Youshan Melissa Lin, Jialing Lee, Jessica Fang Yan Lim, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny and Steve Kah Weng Oh
    Citation: Stem Cell Research & Therapy 2017 8:93
  5. Mesangiogenic progenitor cells (MPCs) have shown the ability to differentiate in-vitro toward mesenchymal stromal cells (MSCs) as well as angiogenic potential. MPCs have so far been described in detail as prog...

    Authors: Marina Montali, Francesca M. Panvini, Serena Barachini, Francesca Ronca, Vittoria Carnicelli, Stefano Mazzoni, Iacopo Petrini and Simone Pacini
    Citation: Stem Cell Research & Therapy 2017 8:106
  6. Radiation enteropathy is a common complication in patients with abdominopelvic cancer, but no treatment has yet been established. Stem cell therapy may be a viable therapeutic option because intestinal stem ce...

    Authors: Young-Min Han, Jong-Min Park, Yong Soo Choi, Hee Jin, Yun-Sil Lee, Na-Young Han, Hookeun Lee and Ki Baik Hahm
    Citation: Stem Cell Research & Therapy 2017 8:105
  7. Satellite cells are quiescent resident muscle stem cells that present an important potential to regenerate damaged tissue. However, this potential is diminished once they are removed from their niche environme...

    Authors: Claire Monge, Nicholas DiStasio, Thomas Rossi, Muriel Sébastien, Hiroshi Sakai, Benoit Kalman, Thomas Boudou, Shahragim Tajbakhsh, Isabelle Marty, Anne Bigot, Vincent Mouly and Catherine Picart
    Citation: Stem Cell Research & Therapy 2017 8:104
  8. Mesenchymal stem cells (MSCs) show promising characteristics for their use in advanced therapy medicinal products. However, there are some unresolved concerns, such as the use of animal components for their ex...

    Authors: Arantxa Blázquez-Prunera, José María Díez, Rodrigo Gajardo and Salvador Grancha
    Citation: Stem Cell Research & Therapy 2017 8:103
  9. In view of the current interest in exploring the clinical use of mesenchymal stem cells (MSCs) from different sources, we performed a side-by-side comparison of the biological properties of MSCs isolated from ...

    Authors: Aristea K. Batsali, Charalampos Pontikoglou, Dimitrios Koutroulakis, Konstantia I. Pavlaki, Athina Damianaki, Irene Mavroudi, Kalliopi Alpantaki, Elisavet Kouvidi, George Kontakis and Helen A. Papadaki
    Citation: Stem Cell Research & Therapy 2017 8:102
  10. Three-dimensional cultured clumps of a mesenchymal stem cell (MSC)/extracellular matrix (ECM) complex (C-MSC) consists of cells and self-produced ECM. C-MSC can regulate the cellular function in vitro and indu...

    Authors: Kei Takeshita, Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita and Hidemi Kurihara
    Citation: Stem Cell Research & Therapy 2017 8:101
  11. Mesenchymal stem cells (MSCs) have entered the clinic as an Advanced Therapy Medicinal Product and are currently evaluated in a wide range of studies for tissue regeneration or in autoimmune disorders. Various...

    Authors: Madeleine C. Killer, Philipp Nold, Katharina Henkenius, Lea Fritz, Tabea Riedlinger, Christina Barckhausen, Miriam Frech, Holger Hackstein, Andreas Neubauer and Cornelia Brendel
    Citation: Stem Cell Research & Therapy 2017 8:100
  12. Human mesenchymal stem cells (MSCs) possess well-known reparative abilities, but any defect of the immunomodulatory activity and/or the differentiation process may determine the development of human diseases, ...

    Authors: Carmen Ciavarella, Enrico Gallitto, Francesca Ricci, Marina Buzzi, Andrea Stella and Gianandrea Pasquinelli
    Citation: Stem Cell Research & Therapy 2017 8:99
  13. Ring finger protein 43 (RNF43) is a member of the transmembrane E3 ubiquitin ligase family that was originally found in stem cells and plays important roles in tumor formation and progression. Our previous stu...

    Authors: Yunhe Gao, Aizhen Cai, Hongqing Xi, Jiyang Li, Wei Xu, Yanmei Zhang, Kecheng Zhang, Jianxin Cui, Xiaosong Wu, Bo Wei and Lin Chen
    Citation: Stem Cell Research & Therapy 2017 8:98
  14. Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis. CD16+ monocytes are proinflammatory and abundant in inflammatory conditions such...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Lanfang Huang, Haijiang Tong, Ping Chen, Dengming Lai, Yaoqin Hu, Baoli Cheng, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2017 8:97
  15. In the field of experimental stem cell therapy, intra-arterial (IA) delivery yields the best results concerning, for example, migrated cell number at the targeted site. However, IA application also appears to ...

    Authors: Saskia Grudzenski, Sebastian Baier, Anne Ebert, Pim Pullens, Andreas Lemke, Karen Bieback, Rick M. Dijkhuizen, Lothar R. Schad, Angelika Alonso, Michael G. Hennerici and Marc Fatar
    Citation: Stem Cell Research & Therapy 2017 8:96
  16. Prostate cancer is the second most frequent cancer among males worldwide, and most patients with metastatic disease eventually develop therapy-resistant disease. Recent research has suggested the existence of ...

    Authors: Jens Adam Ceder, Tilly Wilhelmina Aalders and Jack Antonius Schalken
    Citation: Stem Cell Research & Therapy 2017 8:95
  17. Fibroblasts are ubiquitous cells in the human body and are absolutely necessary for wound healing such as for injured skin. This role of fibroblasts was the reason why we aimed to differentiate human adipose-d...

    Authors: Woojune Hur, Hoon Young Lee, Hye Sook Min, Maierdanjiang Wufuer, Chang-won Lee, Ji An Hur, Sang Hyon Kim, Byeung Kyu Kim and Tae Hyun Choi
    Citation: Stem Cell Research & Therapy 2017 8:92
  18. Human mesenchymal stem cells are promising tools for regenerative medicine due to their ability to differentiate into many cellular types such as osteocytes, chondrocytes and adipocytes amongst many other cell...

    Authors: Hanna Hanna, Franck M. Andre and Lluis M. Mir
    Citation: Stem Cell Research & Therapy 2017 8:91
  19. Stem cell therapy has emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the poor viability of transplanted stem cells hampers their therapeutic efficacy. Hypoxic precondition...

    Authors: Zheng Zhang, Chao Yang, Mingzhi Shen, Ming Yang, Zhitao Jin, Liping Ding, Wei Jiang, Junke Yang, Haixu Chen, Feng Cao and Taohong Hu
    Citation: Stem Cell Research & Therapy 2017 8:89
  20. Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evalu...

    Authors: Nicolas Lanthier, Nathalie Lin-Marq, Laura Rubbia-Brandt, Sophie Clément, Nicolas Goossens and Laurent Spahr
    Citation: Stem Cell Research & Therapy 2017 8:88
  21. The incidence of inflammatory bowel diseases (IBD) is increasing worldwide with patients experiencing severe impacts on their quality of life. It is well accepted that intestinal inflammation associates with e...

    Authors: Ainsley M. Robinson, Ahmed A. Rahman, Sarah Miller, Rhian Stavely, Samy Sakkal and Kulmira Nurgali
    Citation: Stem Cell Research & Therapy 2017 8:87
  22. Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the poten...

    Authors: Violeta Mitutsova, Wendy Wai Yeng Yeo, Romain Davaze, Celine Franckhauser, El-Habib Hani, Syahril Abdullah, Patrice Mollard, Marie Schaeffer, Anne Fernandez and Ned J. C. Lamb
    Citation: Stem Cell Research & Therapy 2017 8:86
  23. Mesenchymal stem cells (MSCs) show therapeutic efficacy in many different age-related degenerative diseases, including Alzheimer’s disease. Very little is currently known about whether or not aging impacts the...

    Authors: Claire Fabian, Yahaira Naaldijk, Christiane Leovsky, Adiv A. Johnson, Lukas Rudolph, Carsten Jaeger, Katrin Arnold and Alexandra Stolzing
    Citation: Stem Cell Research & Therapy 2017 8:85
  24. Severe injuries of the uterus may trigger uterine scar formation, ultimately leading to infertility or obstetrical complications. To date, few methods have adequately solved the problem of collagen deposition ...

    Authors: Lu Xu, Lijun Ding, Lei Wang, Yun Cao, Hui Zhu, Jingjie Lu, Xin’an Li, Tianran Song, Yali Hu and Jianwu Dai
    Citation: Stem Cell Research & Therapy 2017 8:84
  25. Bone marrow-derived mesenchymal stromal cells (MSCs) are multipotent cells with a high constitutive level of autophagy and low expression of CD99. Under certain conditions, MSCs may develop tumorigenic propert...

    Authors: Zvenyslava Husak and Michael N. Dworzak
    Citation: Stem Cell Research & Therapy 2017 8:83
  26. Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We r...

    Authors: Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B. Kirn Safran and Anja Nohe
    Citation: Stem Cell Research & Therapy 2017 8:82
  27. In contrast to humans in which mesenchymal stem/stromal cell (MSC) therapies are still largely in the clinical trial phase, MSCs have been used therapeutically in horses for over 15 years, thus constituting a ...

    Authors: Cristina L. Esteves, Tara A. Sheldrake, Simone P. Mesquita, Juan J. Pesántez, Timothy Menghini, Lucy Dawson, Bruno Péault and F. Xavier Donadeu
    Citation: Stem Cell Research & Therapy 2017 8:80
  28. Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to ...

    Authors: Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan and Emmanuel Pinteaux
    Citation: Stem Cell Research & Therapy 2017 8:79
  29. Pluripotent stem cells (PSCs) such as embryonic stem cells and induced pluripotent stem cells are promising target cells for cell regenerative medicine together with recently advanced technology of in-vitro di...

    Authors: Seok-Jin Kang, Young-Il Park, So-Ryeon Hwang, Hee Yi, Nga Tham, Hyun-Ok Ku, Jae-Young Song and Hwan-Goo Kang
    Citation: Stem Cell Research & Therapy 2017 8:78
  30. Cryopreservation has been extensively applied to the long-term storage of a diverse range of biological materials. However, no comprehensive study is currently available on the cryopreservation of periodontal ...

    Authors: Mengying Li, Cheng Feng, Xiuge Gu, Qin He and Fulan Wei
    Citation: Stem Cell Research & Therapy 2017 8:77
  31. Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefo...

    Authors: Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Lilian Cruz, Vilma Regina Martins, Tiago Góss Santos and Marilene Hohmuth Lopes
    Citation: Stem Cell Research & Therapy 2017 8:76
  32. The administration of cisplatin is limited due to its nephrotoxic side effects, and prevention of this nephrotoxicity of cisplatin is difficult. Mesenchymal stem cell (MSC)-derived exosomes have been implicate...

    Authors: Bingying Wang, Haoyuan Jia, Bin Zhang, Juanjuan Wang, Cheng Ji, Xueming Zhu, Yongmin Yan, Lei Yin, Jing Yu, Hui Qian and Wenrong Xu
    Citation: Stem Cell Research & Therapy 2017 8:75
  33. Human umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not...

    Authors: Lei Huang, Yichu Liu, Jianfei Lu, Bianca Cerqueira, Vivek Misra and Timothy Q. Duong
    Citation: Stem Cell Research & Therapy 2017 8:74
  34. Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair syste...

    Authors: Pavel Simara, Lenka Tesarova, Daniela Rehakova, Pavel Matula, Stanislav Stejskal, Ales Hampl and Irena Koutna
    Citation: Stem Cell Research & Therapy 2017 8:73
  35. The success of developing cardiovascular tissue engineering (CTE) grafts greatly needs a readily available cell substitute for endothelial and interstitial cells. Perinatal annexes have been proposed as a valu...

    Authors: Lei Pu, Mingyao Meng, Jian Wu, Jing Zhang, Zongliu Hou, Hui Gao, Hui Xu, Boyu Liu, Weiwei Tang, Lihong Jiang and Yaxiong Li
    Citation: Stem Cell Research & Therapy 2017 8:72
  36. While it is known that irradiation can induce local and systemic bone loss over time, how focal irradiation induces systemic bone complications remains unclear. Immune cells are thought to be crucial to bone h...

    Authors: Xiaoya Xu, Ruixia Li, Yi Zhou, Qiong Zou, Qiaoling Ding, Jinfeng Wang, Weifang Jin, Guoqiang Hua and Jianjun Gao
    Citation: Stem Cell Research & Therapy 2017 8:71
  37. Mesenchymal stem cells (MSCs) have been studied for the treatment of acute liver failure (ALF) for several years. MSCs may exert their effect via complex paracrine mechanisms. Heme oxygenase (HO) 1, a rate-lim...

    Authors: Zhi-heng Zhang, Wei Zhu, Hao-zhen Ren, Xin Zhao, Shuai Wang, Hu-cheng Ma and Xiao-lei Shi
    Citation: Stem Cell Research & Therapy 2017 8:70
  38. Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine saf...

    Authors: Kaitlin C. Clark, Fernando A. Fierro, Emily Mills Ko, Naomi J. Walker, Boaz Arzi, Clifford G. Tepper, Heather Dahlenburg, Andrew Cicchetto, Amir Kol, Lyndsey Marsh, William J. Murphy, Nasim Fazel and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2017 8:69
  39. Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, ...

    Authors: Lorenzo Nevi, Guido Carpino, Daniele Costantini, Vincenzo Cardinale, Olga Riccioni, Sabina Di Matteo, Fabio Melandro, Pasquale Bartolomeo Berloco, Lola Reid, Eugenio Gaudio and Domenico Alvaro
    Citation: Stem Cell Research & Therapy 2017 8:68
  40. The robust generation of human hematopoietic progenitor cells from induced or embryonic pluripotent stem cells would be beneficial for multiple areas of research, including mechanistic studies of hematopoiesis...

    Authors: Yekaterina Galat, Svetlana Dambaeva, Irina Elcheva, Aaruni Khanolkar, Kenneth Beaman, Philip M. Iannaccone and Vasiliy Galat
    Citation: Stem Cell Research & Therapy 2017 8:67
  41. Successful implementation of rapidly advancing regenerative medicine approaches has led to high demand for readily available cellular suspensions. In particular, multipotent stromal cells (MSCs) of placental o...

    Authors: Denys Pogozhykh, Olena Pogozhykh, Volodymyr Prokopyuk, Larisa Kuleshova, Anatoliy Goltsev, Rainer Blasczyk and Thomas Mueller
    Citation: Stem Cell Research & Therapy 2017 8:66
  42. Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing reta...

    Authors: Tera M. Filion, Jordan D. Skelly, Henry Huang, Dale L. Greiner, David C. Ayers and Jie Song
    Citation: Stem Cell Research & Therapy 2017 8:65
  43. Osteoarthritis (OA) is the most common joint disease worldwide. In the past decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA. A potential mechanism of MSC-based therapies has...

    Authors: Yu Zhu, Yuchen Wang, Bizeng Zhao, Xin Niu, Bin Hu, Qing Li, Juntao Zhang, Jian Ding, Yunfeng Chen and Yang Wang
    Citation: Stem Cell Research & Therapy 2017 8:64
  44. Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcome...

    Authors: Kunal H. Bhatt, Rajeev Rudraraju, Jeremy F. Brooks, Ji-Won Jung, Ryan Galea, James W. Wells and Raymond J. Steptoe
    Citation: Stem Cell Research & Therapy 2017 8:57
  45. CD117 is expressed on double-negative (DN; CD4–CD8–) cells (Nat Rev Immunol 14:529–545; 2014), but whether it is expressed in other stages and its subsequent functions are unclear. We used an improved method of f...

    Authors: Yang Wei, Zhansheng Hu, Wen Gu, Gang Liu, Bingyin Shi, Enqi Liu and Tie Liu
    Citation: Stem Cell Research & Therapy 2017 8:56
  46. Cardiotoxicity remains an important concern in drug discovery. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have become an attractive platform to evaluate cardiotoxicity. However, the consiste...

    Authors: Qi Zhao, Xijie Wang, Shuyan Wang, Zheng Song, Jiaxian Wang and Jing Ma
    Citation: Stem Cell Research & Therapy 2017 8:54
  47. Authors: Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong and Sang-Mo Kwon
    Citation: Stem Cell Research & Therapy 2017 8:50

    The original article was published in Stem Cell Research & Therapy 2016 7:158

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