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  1. This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative ...

    Authors: Eva Koellensperger, Felix Gramley, Fabian Preisner, Uwe Leimer, Guenter Germann and Verena Dexheimer
    Citation: Stem Cell Research & Therapy 2014 5:65
    Content type: Research Published on:

  2. Npas4 is a calcium-dependent transcription factor expressed within neurons of the brain where it regulates the expression of several genes that are important for neuronal survival and synaptic plasticity. It i...

    Authors: Thomas S Klaric, Paul Q Thomas, Mirella Dottori, Wai Khay Leong, Simon A Koblar and Martin D Lewis
    Citation: Stem Cell Research & Therapy 2014 5:64
    Content type: Research Published on:

  3. Human adipose-derived stromal cells (hASCs), due to their relative feasibility of isolation and ability to secrete large amounts of angiogenic factors, are being evaluated for regenerative medicine. However, t...

    Authors: Luigi Balducci, Antonella Blasi, Marilisa Saldarelli, Antonio Soleti, Augusto Pessina, Arianna Bonomi, Valentina Coccè, Marta Dossena, Valentina Tosetti, Valentina Ceserani, Stefania Elena Navone, Maria Laura Falchetti, Eugenio Agostino Parati and Giulio Alessandri
    Citation: Stem Cell Research & Therapy 2014 5:63
    Content type: Research Published on:

  5. We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. This technique has proven to be...

    Authors: Sandra Chapman, David H McDermott, Kui Shen, Moon Kyoo Jang and Alison A McBride
    Citation: Stem Cell Research & Therapy 2014 5:60
    Content type: Research Published on:

  6. Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue en...

    Authors: Ian H Bellayr, Jennifer G Catalano, Samir Lababidi, Amy X Yang, Jessica L Lo Surdo, Steven R Bauer and Raj K Puri
    Citation: Stem Cell Research & Therapy 2014 5:59
    Content type: Research Published on:

  7. Stem cell therapy has recently been introduced to treat patients with type 2 diabetes mellitus (T2DM). However, no data are available on the efficacy and safety of allogeneic Wharton’s Jelly-derived mesenchyma...

    Authors: Xuebin Liu, Pei Zheng, Xiaodong Wang, Guanghui Dai, Hongbin Cheng, Zan Zhang, Rongrong Hua, Xinxin Niu, Jing Shi and Yihua An
    Citation: Stem Cell Research & Therapy 2014 5:57
    Content type: Research Published on:

  8. The cancer stem cell model links neoplastic cells with normal stem cell biology, but little is known on how normal stem cells are transformed into cancer stem cells.

    Authors: Donatella Amendola, Marta Nardella, Loredana Guglielmi, Lidia Cerquetti, Elisabetta Carico, Viola Alesi, Manuela Porru, Carlo Leonetti, Claudia Bearzi, Roberto Rizzi, Igea D’Agnano, Antonio Stigliano, Giuseppe Novelli and Barbara Bucci
    Citation: Stem Cell Research & Therapy 2014 5:55
    Content type: Research Published on:

  9. Although mesenchymal stem cells (MSCs) have antitumor potential in hepatocellular carcinoma and breast cancer cells, the antitumor mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) in prostate...

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim
    Citation: Stem Cell Research & Therapy 2014 5:54
    Content type: Research Published on:

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2018 9:354

  10. Different mesenchymal stromal cells (MSC) have been successfully isolated and expanded in vitro and nowadays they are tested in clinical trials for a wide variety of diseases. Whether all MSC express the same cel...

    Authors: Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2014 5:53
    Content type: Research Published on:

  11. Gingiva-derived mesenchymal stem cells (GMSCs) have recently been harvested and applied for rebuilding lost periodontal tissue. Enamel matrix derivative (EMD) has been used for periodontal regeneration and the...

    Authors: Shu-Man Wu, Hsien-Chung Chiu, Yu-Tang Chin, Heng-Yi Lin, Cheng-Yang Chiang, Hsiao-Pei Tu, Martin MJ Fu and Earl Fu
    Citation: Stem Cell Research & Therapy 2014 5:52
    Content type: Research Published on:

  12. Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer’s disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the under...

    Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A Castello, Andranik A Agazaryan, Joy L Davis, Franz-Josef Müller, Jeanne F Loring, Eliezer Masliah and Frank M LaFerla
    Citation: Stem Cell Research & Therapy 2014 5:46
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:88

  13. Adipose tissue has the unique property of expanding throughout adult life, and angiogenesis is required for its growth. However, endothelial progenitor cells contribute minimally to neovascularization. Because...

    Authors: Amparo Navarro, Severiano Marín, Nicasia Riol, Francisco Carbonell-Uberos and María Dolores Miñana
    Citation: Stem Cell Research & Therapy 2014 5:50
    Content type: Research Published on:

  15. Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics...

    Authors: Yongzhao Zhu, Yinxue Yang, Yaolin Zhang, Guiliang Hao, Ting Liu, Libin Wang, Tingting Yang, Qiong Wang, Guangyi Zhang, Jun Wei and Yukui Li
    Citation: Stem Cell Research & Therapy 2014 5:48
    Content type: Research Published on:

  16. Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertiona...

    Authors: Asifiqbal Kadari, Min Lu, Ming Li, Thileepan Sekaran, Rajkumar P Thummer, Naomi Guyette, Vi Chu and Frank Edenhofer
    Citation: Stem Cell Research & Therapy 2014 5:47
    Content type: Method Published on:

  17. Stroke is the second leading cause of death worldwide, claims six lives every 60 seconds, and is a leading cause of adult disability across the globe. Tissue plasminogen activator, the only United States Food ...

    Authors: Neha Karlupia, Nathan C Manley, Kameshwar Prasad, Richard Schäfer and Gary K Steinberg
    Citation: Stem Cell Research & Therapy 2014 5:45
    Content type: Research Published on:

  18. Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill subjects, sepsis and severe bacterial pneumonia being its most common causes. The only interventi...

    Authors: Mauricio Rojas, Nayra Cárdenes, Ergin Kocyildirim, John R Tedrow, Eder Cáceres, Robert Deans, Anthony Ting and Christian Bermúdez
    Citation: Stem Cell Research & Therapy 2014 5:42
    Content type: Research Published on:

  19. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed as an ideal autologous stem cell source for cell-based therapy for myocardial infarction (MI). However, decreased viability and impaired ...

    Authors: Zheng Zhang, Chuanxu Zhao, Bing Liu, Dong Liang, Xing Qin, Xiujuan Li, Rongqing Zhang, Congye Li, Haichang Wang, Dongdong Sun and Feng Cao
    Citation: Stem Cell Research & Therapy 2014 5:33
    Content type: Research Published on:

  20. A mouse model of progeria derived by insertion of the human mutant LMNA gene (mLMNA), producing mutant lamin A, shows loss of smooth muscle cells in the media of the ascending aorta. We hypothesized that high she...

    Authors: Minjung Song, Hong San, Stasia A Anderson, Richard O Cannon III and Donald Orlic
    Citation: Stem Cell Research & Therapy 2014 5:41
    Content type: Research Published on:

  21. Studies have demonstrated that mesenchymal stromal cells (MSCs) could reverse acute and chronic kidney injury by a paracrine or endocrine mechanism, and microvesicles (MVs) have been regarded as a crucial mean...

    Authors: Xiangyu Zou, Guangyuan Zhang, Zhongliang Cheng, Deming Yin, Tao Du, Guanqun Ju, Shuai Miao, Guohua Liu, Mujun Lu and Yingjian Zhu
    Citation: Stem Cell Research & Therapy 2014 5:40
    Content type: Research Published on:

  22. The present work was designed to explore the feasibility and efficacy of articular cartilage repair using composites of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) and four different ...

    Authors: Jun Young Chung, Minjung Song, Chul-Won Ha, Jin-A Kim, Choong-Hee Lee and Yong-Beom Park
    Citation: Stem Cell Research & Therapy 2014 5:39
    Content type: Research Published on:

  23. Elevated midkine (MK) expression may contribute to ventricular remodeling and ameliorate cardiac dysfunction after myocardial infarction (MI). Ex vivo modification of signaling mechanisms in mesenchymal stem cell...

    Authors: Shu-Li Zhao, Yao-Jun Zhang, Ming-Hui Li, Xin-Lei Zhang and Shao-Liang Chen
    Citation: Stem Cell Research & Therapy 2014 5:37
    Content type: Research Published on:

  24. Fibronectin (FN) is commonly used in the development of serum-free media for the expansion of mesenchymal stem cells (MSCs). This study was aimed to observe if thrombin could stimulate FN secretion by human bo...

    Authors: Jin Chen, Yujie Ma, Zi Wang, Hengxiang Wang, Lisheng Wang, Fengjun Xiao, Hua Wang, Jianming Tan and Zikuan Guo
    Citation: Stem Cell Research & Therapy 2014 5:36
    Content type: Research Published on:

  25. Human induced pluripotent stem cells (hiPSCs) offer great promise for regenerative therapies or in vitro modelling of neurodegenerative disorders like Parkinson’s disease. Currently, widely used cell sources for ...

    Authors: Nancy Stanslowsky, Alexandra Haase, Ulrich Martin, Maximilian Naujock, Andreas Leffler, Reinhard Dengler and Florian Wegner
    Citation: Stem Cell Research & Therapy 2014 5:35
    Content type: Research Published on:

  26. Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem...

    Authors: Johannes FW Greiner, Lena-Marie Grunwald, Janine Müller, Holger Sudhoff, Darius Widera, Christian Kaltschmidt and Barbara Kaltschmidt
    Citation: Stem Cell Research & Therapy 2014 5:34
    Content type: Research Published on:

  27. During normal pulp tissue healing, inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) or interleukins, act in the initial 48 hours (inflammatory phase) and play important roles not only as che...

    Authors: Mayu Ueda, Takuo Fujisawa, Mitsuaki Ono, Emilio Satoshi Hara, Hai Thanh Pham, Ryu Nakajima, Wataru Sonoyama and Takuo Kuboki
    Citation: Stem Cell Research & Therapy 2014 5:31
    Content type: Research Published on:

  28. Interest in the use of dental pulp stem cells (DPSC) to enhance neurological recovery following stroke and traumatic injury is increasing following successful pre-clinical studies. A murine model of autologous...

    Authors: Kylie M Ellis, David C O’Carroll, Martin D Lewis, Grigori Y Rychkov and Simon A Koblar
    Citation: Stem Cell Research & Therapy 2014 5:30
    Content type: Research Published on:

  29. Transplanting mesenchymal stromal cells (MSCs) or their derivatives into a neurodegenerative environment is believed to be beneficial because of the trophic support, migratory guidance, immunosuppression, and ...

    Authors: Irina Aizman, Brenna J Tirumalashetty, Michael McGrogan and Casey C Case
    Citation: Stem Cell Research & Therapy 2014 5:29
    Content type: Research Published on:

  30. The prevalence of nonhealing wounds is predicted to increase due to the growing aging population. Despite the use of novel skin substitutes and wound dressings, poorly vascularized wound niches impair wound re...

    Authors: Anna I Arno, Saeid Amini-Nik, Patrick H Blit, Mohammed Al-Shehab, Cassandra Belo, Elaine Herer, Col Homer Tien and Marc G Jeschke
    Citation: Stem Cell Research & Therapy 2014 5:28
    Content type: Research Published on:

  31. Mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and bone tissue engineering given their ability to differentiate into chondrocytes and osteoblasts. However, the common origin of these...

    Authors: Farida Djouad, Gautier Tejedor, Karine Toupet, Marie Maumus, Claire Bony, Anne Blangy, Paul Chuchana, Christian Jorgensen and Danièle Noël
    Citation: Stem Cell Research & Therapy 2014 5:27
    Content type: Research Published on:

  32. Stem cells are being investigated as catalysts of tissue regeneration to either directly replace or promote cellularity lost as a result of traumatic injury or degenerative disease. In many reports, despite lo...

    Authors: Alyssa V Ngangan, James C Waring, Marissa T Cooke, Christian J Mandrycky and Todd C McDevitt
    Citation: Stem Cell Research & Therapy 2014 5:26
    Content type: Research Published on:

  33. Studies with mesenchymal stem cells (MSCs) are increasing due to their immunomodulatory, anti-inflammatory and tissue regenerative properties. However, there is still no agreement about the best source of equi...

    Authors: Danielle Jaqueta Barberini, Natália Pereira Paiva Freitas, Mariana Sartori Magnoni, Leandro Maia, Amanda Jerônimo Listoni, Marta Cristina Heckler, Mateus Jose Sudano, Marjorie Assis Golim, Fernanda da Cruz Landim-Alvarenga and Rogério Martins Amorim
    Citation: Stem Cell Research & Therapy 2014 5:25
    Content type: Research Published on:

  34. Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular cells assemble into a complex regulati...

    Authors: Torbjorn O Pedersen, Anna L Blois, Ying Xue, Zhe Xing, Yang Sun, Anna Finne-Wistrand, James B Lorens, Inge Fristad, Knut N Leknes and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2014 5:23
    Content type: Research Published on:

  35. Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness within the first two years of life. Collagen VI-related mu...

    Authors: Vitali Alexeev, Machiko Arita, Adele Donahue, Paolo Bonaldo, Mon-Li Chu and Olga Igoucheva
    Citation: Stem Cell Research & Therapy 2014 5:21
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) have potential for the treatment of myocardial infarction. However, several meta-analyses revealed that the outcome of stem cell transplantation is dissatisfactory. A series of st...

    Authors: Bingqing Huang, Juying Qian, Jianying Ma, Zheyong Huang, Yunli Shen, Xueying Chen, Aijun Sun, Junbo Ge and Haozhu Chen
    Citation: Stem Cell Research & Therapy 2014 5:22
    Content type: Research Published on:

  37. Oxidative stress is implicated in tissue inflammation, and plays an important role in the pathogenesis of immune-mediated nephritis. Using the anti-glomerular basement membrane antibody-induced glomerulonephri...

    Authors: Yajuan Li, Mei Yan, Jichen Yang, Indu Raman, Yong Du, Soyoun Min, Xiangdong Fang, Chandra Mohan and Quan-Zhen Li
    Citation: Stem Cell Research & Therapy 2014 5:19
    Content type: Research Published on:

  38. Chronic wounds are a major health-care issue, but research is limited by the complexity and heterogeneity in terms of wound etiology as well as patient-related factors. A suitable animal model that replicates ...

    Authors: Reto Wettstein, Miodrag Savic, Gerhard Pierer, Oliver Scheufler, Martin Haug, Jörg Halter, Alois Gratwohl, Michael Baumberger, Dirk Johannes Schaefer and Daniel Felix Kalbermatten
    Citation: Stem Cell Research & Therapy 2014 5:18
    Content type: Research Published on:

  39. The identification of new progenitor cell sources is important for cell-based tissue engineering strategies, understanding regional tissue regeneration, and modulating local microenvironments and immune respon...

    Authors: Kyu-Sup Cho, Hee-Young Park, Hwan-Jung Roh, Dawn T Bravo, Peter H Hwang and Jayakar V Nayak
    Citation: Stem Cell Research & Therapy 2014 5:15
    Content type: Research Published on:

  40. Although stem cell therapy is a promising treatment for myocardial infarction, the minimal functional improvements observed clinically limit its widespread application. A need exists to maximize the therapeuti...

    Authors: Kelly Elizabeth Sullivan, Kyle Patrick Quinn, Katherine Michele Tang, Irene Georgakoudi and Lauren Deems Black III
    Citation: Stem Cell Research & Therapy 2014 5:14
    Content type: Research Published on:

  41. The horse is a valuable species to assess the effect of allogeneic mesenchymal stromal cells (MSCs) in regenerative treatments. No studies to date have examined recipient response to major histocompatibility c...

    Authors: Lauren V Schnabel, Lynn M Pezzanite, Douglas F Antczak, M Julia Bevilaqua Felippe and Lisa A Fortier
    Citation: Stem Cell Research & Therapy 2014 5:13
    Content type: Research Published on:

  42. Standardization of mesenchymal stromal cells (MSCs) manufacturing is urgently needed to enable translational activities and ultimately facilitate comparison of clinical trial results. In this work we describe ...

    Authors: José Paulo Martins, Jorge Miguel Santos, Joana Martode Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz…
    Citation: Stem Cell Research & Therapy 2014 5:9
    Content type: Research Published on:

  43. Regenerative medicine challenges researchers to find noncontroversial, safe and abundant stem cell sources. In this context, harvesting from asystolic donors could represent an innovative and unlimited reservo...

    Authors: Sabrina Valente, Francesco Alviano, Carmen Ciavarella, Marina Buzzi, Francesca Ricci, Pier Luigi Tazzari, Pasqualepaolo Pagliaro and Gianandrea Pasquinelli
    Citation: Stem Cell Research & Therapy 2014 5:8
    Content type: Research Published on:

  44. Silk fibroin (SF) scaffolds have been shown to be a suitable substrate for tissue engineering and to improve tissue regeneration when cellularized with mesenchymal stromal cells (MSCs). We here demonstrate, fo...

    Authors: Stefania Elena Navone, Luisa Pascucci, Marta Dossena, Anna Ferri, Gloria Invernici, Francesco Acerbi, Silvia Cristini, Gloria Bedini, Valentina Tosetti, Valentina Ceserani, Arianna Bonomi, Augusto Pessina, Giuliano Freddi, Antonio Alessandrino, Piero Ceccarelli, Rolando Campanella…
    Citation: Stem Cell Research & Therapy 2014 5:7
    Content type: Research Published on:

  45. Mesenchymal stromal cells (MSCs) have been extensively studied for their promising capabilities in regenerative medicine. Although bone marrow is the best-known source for isolating equine MSCs, non-invasive a...

    Authors: Catharina De Schauwer, Karen Goossens, Sofie Piepers, Maarten K Hoogewijs, Jan LJ Govaere, Katrien Smits, Evelyne Meyer, Ann Van Soom and Gerlinde R Van de Walle
    Citation: Stem Cell Research & Therapy 2014 5:6
    Content type: Research Published on:

  46. Among the plethora of cells under investigation to restore a functional myocardium, mesenchymal stromal cells (MSCs) have been granted considerable interest. However, whereas the beneficial effects of bone mar...

    Authors: Diana Santos Nascimento, Diogo Mosqueira, Luís Moura Sousa, Mariana Teixeira, Mariana Filipe, Tatiana Pinho Resende, Ana Francisca Araújo, Mariana Valente, Joana Almeida, José Paulo Martins, Jorge Miguel Santos, Rita Nogueira Bárcia, Pedro Cruz, Helder Cruz and Perpétua Pinto-do-Ó
    Citation: Stem Cell Research & Therapy 2014 5:5
    Content type: Research Published on:

  47. Overweight status should not be considered merely an aesthetic concern; rather, it can incur health risks since it may trigger a cascade of events that produce further fat tissue through altered levels of circ...

    Authors: Giovanni Di Bernardo, Giovanni Messina, Stefania Capasso, Stefania Del Gaudio, Marilena Cipollaro, Gianfranco Peluso, Fiorina Casale, Marcellino Monda and Umberto Galderisi
    Citation: Stem Cell Research & Therapy 2014 5:4
    Content type: Research Published on:

  48. Despite having a proven immunosuppressive potential in vitro, human mesenchymal stromal cells (MSCs) are reported to display variable efficacy in vivo and, in fact, their proven benefit in the clinical practice i...

    Authors: Erica Valencic, Claudia Loganes, Stefania Cesana, Elisa Piscianz, Giuseppe Gaipa, Ettore Biagi and Alberto Tommasini
    Citation: Stem Cell Research & Therapy 2014 5:3
    Content type: Research Published on:

  49. While administration of ex vivo culture-expanded stem cells has been used to study immunosuppressive mechanisms in multiple models of autoimmune diseases, less is known about the uncultured, nonexpanded stromal v...

    Authors: Julie A Semon, Catherine Maness, Xiujuan Zhang, Steven A Sharkey, Marc M Beuttler, Forum S Shah, Amitabh C Pandey, Jeffrey M Gimble, Shijia Zhang, Brittni A Scruggs, Amy L Strong, Thomas A Strong and Bruce A Bunnell
    Citation: Stem Cell Research & Therapy 2014 5:2
    Content type: Research Published on:
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