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  1. Human neural stem cell transplants have potential as therapeutic candidates to treat a vast number of disorders of the central nervous system (CNS). StemCells, Inc. has purified human neural stem cells and dev...

    Authors: Ann Tsukamoto, Nobuko Uchida, Alexandra Capela, Thorsten Gorba and Stephen Huhn
    Citation: Stem Cell Research & Therapy 2013 4:102
    Content type: Review Published on:

  2. Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in d...

    Authors: Nathalie De Vocht, Jelle Praet, Kristien Reekmans, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Zwi Berneman, Annemie Van der Linden and Peter Ponsaerts
    Citation: Stem Cell Research & Therapy 2013 4:101
    Content type: Review Published on:

  3. Twenty years ago glial cells were shown to contribute to neuronal information processing, instead of merely supporting neuronal function, thus challenging the century old neuron doctrine. Due to the lack of ap...

    Authors: Sonia Spitzer, Sylvia Agathou and Ragnhildur Thora Karadottir
    Citation: Stem Cell Research & Therapy 2013 4:100
    Content type: Commentary Published on:

  4. Guided migration of chondrogenically differentiated cells has not been well studied, even though it may be critical for growth, repair, and regenerative processes. The chemokine CCL25 is believed to play a cri...

    Authors: Mujib Ullah, Jan Eucker, Michael Sittinger and Jochen Ringe
    Citation: Stem Cell Research & Therapy 2013 4:99
    Content type: Research Published on:

  6. Heart diseases remain a major cause of mortality and morbidity worldwide. However, terminally differentiated human adult cardiomyocytes (CMs) possess a very limited innate ability to regenerate. Directed diffe...

    Authors: Maggie Zi Chow, Kenneth R Boheler and Ronald A Li
    Citation: Stem Cell Research & Therapy 2013 4:97
    Content type: Review Published on:

  7. Vascularization remains one of the primary obstacles in the repair of bone defects. In the previous issue of Stem Cell Research & Therapy, Pedersen and colleagues show that co-immobilization of endothelial cells ...

    Authors: Meadhbh Aín Brennan, Jean-Michel Davaine and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2013 4:96
    Content type: Commentary Published on:

  9. Retinal Müller cells exhibit the characteristics of retinal progenitor cells, and differentiate into ganglion cells under certain conditions. However, the number of ganglion cells differentiated from retinal M...

    Authors: Wei-tao Song, Xue-yong Zhang and Xiao-bo Xia
    Citation: Stem Cell Research & Therapy 2013 4:94
    Content type: Research Published on:

  10. Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous hea...

    Authors: Danielle Drury-Stewart, Mingke Song, Osama Mohamad, Ying Guo, Xiaohuan Gu, Dongdong Chen and Ling Wei
    Citation: Stem Cell Research & Therapy 2013 4:93
    Content type: Research Published on:

  11. Multipotent mesenchymal stromal cells (MSCs) have gained considerable interest because of their potential use in the treatment of a variety of diseases and injuries. Although remarkable advancements have been ...

    Authors: Carolina Soares Barros Melo, Jerusa Araújo Quintão Arantes Faria, Natássia Caroline Resende Corrêa, Carolina de Andrade, Juliana Lott Carvalho, Alfredo M Goes, Michele A Rodrigues and Dawidson Assis Gomes
    Citation: Stem Cell Research & Therapy 2013 4:92
    Content type: Research Published on:

  12. Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy reg...

    Authors: Phuc Van Pham, Khanh Hong-Thien Bui, Dat Quoc Ngo, Ngoc Bich Vu, Nhung Hai Truong, Nhan Lu-Chinh Phan, Dung Minh Le, Triet Dinh Duong, Thanh Duc Nguyen, Vien Tuong Le and Ngoc Kim Phan
    Citation: Stem Cell Research & Therapy 2013 4:91
    Content type: Research Published on:

  14. Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after ac...

    Authors: Pei-Rong Wang
    Citation: Stem Cell Research & Therapy 2013 4:89
    Content type: Commentary Published on:

  15. Resistance of cancer stem/progenitor cells (CSPCs) to chemotherapy can lead to cancer relapse. Ovarian teratocarcinoma (OVTC) arises from germ cells and comprises pluripotent cells that can be used to study ca...

    Authors: Wei-Min Chung, Wei-Chun Chang, Lumin Chen, Ying-Yi Chang, Chih-Rong Shyr, Yao-Ching Hung and Wen-Lung Ma
    Citation: Stem Cell Research & Therapy 2013 4:88
    Content type: Research Published on:

  16. The reprogramming of a patient’s somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially onco...

    Authors: Jason P Awe, Patrick C Lee, Cyril Ramathal, Agustin Vega-Crespo, Jens Durruthy-Durruthy, Aaron Cooper, Saravanan Karumbayaram, William E Lowry, Amander T Clark, Jerome A Zack, Vittorio Sebastiano, Donald B Kohn, April D Pyle, Martin G Martin, Gerald S Lipshutz, Patricia E Phelps…
    Citation: Stem Cell Research & Therapy 2013 4:87
    Content type: Research Published on:

  17. BALB/c mice and C57/BL6 mice have different abilities to recover from ischemia. C57/BL6 mice display increased vessel collateralization and vascular endothelial growth factor expression with a consequent rapid...

    Authors: Flavia Franco Cunha, Leonardo Martins, Priscila Keiko Matsumoto Martin, Roberta Sessa Stilhano and Sang Won Han
    Citation: Stem Cell Research & Therapy 2013 4:86
    Content type: Research Published on:

  18. Tendon injury is a major cause of lameness and decreased performance in athletic equines. Various therapies for tendonitis have been described; however, none of these therapies results in complete tissue regen...

    Authors: Armandode Mattos Carvalho, Peres Ramos Badial, Luis Emiliano Cisneros Álvarez, Ana Lucia Miluzzi Yamada, Alexandre Secorun Borges, Elenice Deffune, Carlos Alberto Hussni and Ana Liz Garcia Alves
    Citation: Stem Cell Research & Therapy 2013 4:85
    Content type: Research Published on:

  19. Epidermal neural crest stem cells (EPI-NCSCs) in the bulge of hair follicles are a promising source for cell-replacement therapies in neurodegenerative diseases. A prominent factor in cell-based therapy is the...

    Authors: Sareh Pandamooz, Mohammad Naji, Farid Alinezhad, Amin Zarghami and Mohsen Pourghasem
    Citation: Stem Cell Research & Therapy 2013 4:84
    Content type: Research Published on:

  20. Bone marrow mesenchymal stem cells (BMMSCs) have been reported to facilitate liver regeneration after toxic injuries. However, the effect of BMMSCs on liver regeneration after massive hepatectomy is barely stu...

    Authors: Jun Yu, Shengyong Yin, Wu Zhang, Feng Gao, Yuanxing Liu, Zhiyun Chen, Min Zhang, Jiangjuan He and Shusen Zheng
    Citation: Stem Cell Research & Therapy 2013 4:83
    Content type: Research Published on:

  21. Although blinding is a methodologic safeguard to ensure obtaining comparability of groups in a clinical trial, it is very difficult to maintain blinding from the beginning to the end of a study. The aim of the...

    Authors: Hyunsuk Jeong, Hyeon Woo Yim, Youngseung Cho, Hun Jun Park, Sona Jeong, Hyun-bin Kim, Wonhee Hong and Heejung Kim
    Citation: Stem Cell Research & Therapy 2013 4:82
    Content type: Research Published on:

  22. Human Wharton’s jelly (WJ) has become a preferred source of mesenchymal stem cells (MSCs) whose clinical applications are limited by the use of adequate xeno-free (XF), in vitro manipulation conditions. Therefore...

    Authors: Maria Cristina Corotchi, Mirel Adrian Popa, Anca Remes, Livia Elena Sima, Ilinca Gussi and Marilena Lupu Plesu
    Citation: Stem Cell Research & Therapy 2013 4:81
    Content type: Research Published on:

  23. Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorat...

    Authors: Min Sun, Shufang Wang, Yi Li, Ling Yu, Fang Gu, Changyong Wang and Yuanqing Yao
    Citation: Stem Cell Research & Therapy 2013 4:80
    Content type: Research Published on:

  24. Obesity, which is excessive expansion of white adipose tissue, is a major risk factor for several serious health issues, including diabetes, cardiovascular disease and cancer. Efforts to combat obesity and rel...

    Authors: Zachary A Schiller, Nathan R Schiele, James K Sims, Kyongbum Lee and Catherine K Kuo
    Citation: Stem Cell Research & Therapy 2013 4:79
    Content type: Research Published on:

  25. Nestin-expressing cells isolated from different human tissues reveal self-renewal capacity and a multilineage differentiation potential. In particular, adult stem/progenitor cell populations from exocrine glan...

    Authors: Anja Richter, Nicole Nissen, Peter Mailänder, Felix Stang, Frank Siemers, Charli Kruse and Sandra Danner
    Citation: Stem Cell Research & Therapy 2013 4:78
    Content type: Research Published on:

  26. Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the central nervous system (CNS). Minocycline ameliorates the clinical severity of MS and exhibits antiinflammatory, neuroprote...

    Authors: Yun Hou, Chung Heon Ryu, Kwang Ywel Park, Seong Muk Kim, Chang Hyun Jeong and Sin-Soo Jeun
    Citation: Stem Cell Research & Therapy 2013 4:77
    Content type: Research Published on:

  27. Cell therapy is a potential therapeutic approach for neurodegenerative disorders, such as Alzheimer disease (AD). Neuronal differentiation of stem cells before transplantation is a promising procedure for cell...

    Authors: Hui Yang, Zhao Hong Xie, Li Fei Wei, Hong Na Yang, Shao Nan Yang, Zheng Yu Zhu, Ping Wang, Cui Ping Zhao and Jian Zhong Bi
    Citation: Stem Cell Research & Therapy 2013 4:76
    Content type: Research Published on:

  28. Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell...

    Authors: Christopher J O’Conor, Natasha Case and Farshid Guilak
    Citation: Stem Cell Research & Therapy 2013 4:61
    Content type: Review Published on:

  29. The corneal stroma is being increasingly recognized as a repository for stem cells. Like the limbal and endothelial niches, stromal stem cells often reside in the peripheral cornea and limbus. These peripheral...

    Authors: Khurram Hashmani, Matthew James Branch, Laura Elizabeth Sidney, Permesh Singh Dhillon, Megha Verma, Owen Douglas McIntosh, Andrew Hopkinson and Harminder Singh Dua
    Citation: Stem Cell Research & Therapy 2013 4:75
    Content type: Research Published on:

  30. So far, no effective therapy is available for acute kidney injury (AKI), a common and serious complication with high morbidity and mortality. Interest has recently been focused on the potential therapeutic eff...

    Authors: Xiao Han, Li Zhao, Guodong Lu, Junke Ge, Yalin Zhao, Shulu Zu, Mingzhen Yuan, Yuqiang Liu, Feng Kong, Zhiying Xiao and Shengtian Zhao
    Citation: Stem Cell Research & Therapy 2013 4:74
    Content type: Research Published on:

  31. Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hemat...

    Authors: Wai Feng Lim, Tomoko Inoue-Yokoo, Keai Sinn Tan, Mei I Lai and Daisuke Sugiyama
    Citation: Stem Cell Research & Therapy 2013 4:71
    Content type: Review Published on:

  32. Stroke is a major cause of permanent neurologic damage, with few effective treatments available to restore lost function. Induced pluripotent stem cells (iPSCs) have the potential to generate all cell types in vi...

    Authors: Ting Yuan, Wei Liao, Nian-Hua Feng, Yuan-Lei Lou, Xin Niu, Ai-Jun Zhang, Yang Wang and Zhi-Feng Deng
    Citation: Stem Cell Research & Therapy 2013 4:73
    Content type: Research Published on:

  33. Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and ...

    Authors: Ko-Jo Lin, Mei-Xue Loi, Gi-Shih Lien, Chieh-Feng Cheng, Hsiang-Yin Pao, Yun-Chuang Chang, Andrea Tung-Qian Ji and Jennifer Hui-Chun Ho
    Citation: Stem Cell Research & Therapy 2013 4:72
    Content type: Research Published on:

  34. Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues. This behavior of MSCs has been exploited as a tumor-targeting strategy for cell-based cancer therapy. However, the effects of MSCs on tumor ...

    Authors: Ting Zhang, Yuk Wai Lee, Yun Feng Rui, Tin Yan Cheng, Xiao Hua Jiang and Gang Li
    Citation: Stem Cell Research & Therapy 2013 4:70
    Content type: Research Published on:

  36. The use of immortalized neural stem cells either as models of neural development in vitro or as cellular therapies in central nervous system (CNS) disorders has been controversial. This controversy has centered o...

    Authors: Graham Cocks, Nataliya Romanyuk, Takashi Amemori, Pavla Jendelova, Oksana Forostyak, Aaron R Jeffries, Leo Perfect, Sandrine Thuret, Govindan Dayanithi, Eva Sykova and Jack Price
    Citation: Stem Cell Research & Therapy 2013 4:69
    Content type: Research Published on:

  37. A growing number of studies have highlighted the potential of stem cell and more-differentiated neural cell transplantation as intriguing therapeutic approaches for neural repair after spinal cord injury (SCI).

    Authors: Takashi Amemori, Nataliya Romanyuk, Pavla Jendelova, Vit Herynek, Karolina Turnovcova, Pavel Prochazka, Miroslava Kapcalova, Graham Cocks, Jack Price and Eva Sykova
    Citation: Stem Cell Research & Therapy 2013 4:68
    Content type: Research Published on:

  38. Platelet-rich plasma (PRP) is nowadays widely applied in different clinical scenarios, such as orthopedics, ophthalmology and healing therapies, as a growth factor pool for improving tissue regeneration. Studi...

    Authors: Paola Romina Amable, Rosana Bizon Vieira Carias, Marcus Vinicius Telles Teixeira, Ítalo da Cruz Pacheco, Ronaldo José Farias Corrêa do Amaral, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2013 4:67
    Content type: Research Published on:

  39. Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. The increasing use of MSCs, ...

    Authors: Luc Sensebé, Mélanie Gadelorge and Sandrine Fleury-Cappellesso
    Citation: Stem Cell Research & Therapy 2013 4:66
    Content type: Review Published on:

  42. Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes,...

    Authors: Patricia Luz-Crawford, Monica Kurte, Javiera Bravo-Alegría, Rafael Contreras, Estefania Nova-Lamperti, Gautier Tejedor, Danièle Noël, Christian Jorgensen, Fernando Figueroa, Farida Djouad and Flavio Carrión
    Citation: Stem Cell Research & Therapy 2013 4:65
    Content type: Research Published on:

  43. Based on some well-documented reports, we attempted to clarify the antifibrotic mechanisms of human Wharton’s-jelly-derived mesenchymal stromal cells (WJ-MSCs) from the perspective of induction of hepatocyte g...

    Authors: Tao Du, Xiangyu Zou, Jun Cheng, Shuai Wu, Liang Zhong, Guanqun Ju, Jiang Zhu, Guohua Liu, Yingjian Zhu and Shujie Xia
    Citation: Stem Cell Research & Therapy 2013 4:59
    Content type: Research Published on:

  44. Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/pcrine release of factors. The delivery of growth factors, cytokines,...

    Authors: Stefania Bruno and Benedetta Bussolati
    Citation: Stem Cell Research & Therapy 2013 4:55
    Content type: Commentary Published on:

  45. This study tested the hypothesis that cyclosporine (CsA)-supported syngeneic adipose-derived mesenchymal stem cell (ADMSC) therapy offered superior attenuation of acute ischemia–reperfusion (IR) kidney injury ...

    Authors: Yen-Ta Chen, Chih-Chau Yang, Yen-Yi Zhen, Christopher Glenn Wallace, Jenq-Lin Yang, Cheuk-Kwan Sun, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Sarah Chua, Chia-Lo Chang, Chung-Lung Cho, Steve Leu and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2013 4:62
    Content type: Research Published on:

  47. Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide trophic support to improve surviva...

    Authors: Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci and Martin Marsala
    Citation: Stem Cell Research & Therapy 2013 4:57
    Content type: Research Published on:

  48. Human hematopoietic stem cells (HSCs) have been clinically used for transplantation and gene and cellular therapy for more than 4 decades. However, this use is limited because of the challenges in the ex vivo cul...

    Authors: Kiranpreet Kaur, Mohammad Reza Mirlashari, Gunnar Kvalheim and Jens Kjeldsen-Kragh
    Citation: Stem Cell Research & Therapy 2013 4:60
    Content type: Research Published on:

  49. Mesenchymal stem cells (MSCs) have the potential for treatment of diabetic cardiomyopathy; however, the repair capability of MSCs declines with age and disease. MSCs from diabetic animals exhibit impaired surv...

    Authors: Mohsin Khan, Fatima Ali, Sadia Mohsin, Shoaib Akhtar, Azra Mehmood, Mahmood S Choudhery, Shaheen N Khan and Sheikh Riazuddin
    Citation: Stem Cell Research & Therapy 2013 4:58
    Content type: Research Published on:

  50. Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome th...

    Authors: Eun Mi Lee, Sunghoon Hurh, Bumrae Cho, Kook-Hwan Oh, Seung U Kim, Charles D Surh, Jonathan Sprent, Jaeseok Yang, Jae Young Kim and Curie Ahn
    Citation: Stem Cell Research & Therapy 2013 4:56
    Content type: Research Published on:
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