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  1. Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could ...

    Authors: Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak and Heikki Ruskoaho
    Citation: Stem Cell Research & Therapy 2021 12:190
    Content type: Research Published on:

  2. The potential of regenerative medicine to improve human health has led to the rapid expansion of stem cell clinics throughout the world with varying levels of regulation and oversight. This has led to a market...

    Authors: Javier Chavez, Neal A. Shah, Severin Ruoss, Raphael E. Cuomo, Samuel R. Ward and Tim K. Mackey
    Citation: Stem Cell Research & Therapy 2021 12:189
    Content type: Research Published on:

  3. Neural stem cell (NSC) therapy remains one of the most potential approaches for the treatment of neurological disorders. The discovery of human induced pluripotent stem cells (hiPSCs) and the establishment of ...

    Authors: Shuai Li, Huifang Zhao, Xiaobo Han, Bin Ni, Lang He, Omar Mukama, Jean de Dieu Habimana, Zuoxian Lin, Rongqi Huang, Hualin Huang, Chao Tian, Feng Tang and Zhiyuan Li
    Citation: Stem Cell Research & Therapy 2021 12:188
    Content type: Research Published on:

  4. Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regenerati...

    Authors: Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen and Nathan P. Staff
    Citation: Stem Cell Research & Therapy 2021 12:187
    Content type: Research Published on:

  5. Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, the peritoneal metastasis, and the relapse, but also for the acquisition ...

    Authors: Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang and Xingsheng Yang
    Citation: Stem Cell Research & Therapy 2021 12:186
    Content type: Research Published on:

  6. This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMS...

    Authors: Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li and Chenping Zhang
    Citation: Stem Cell Research & Therapy 2021 12:185
    Content type: Research Published on:

  7. Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many criti...

    Authors: Maria Florian, Jia-Pey Wang, Yupu Deng, Luciana Souza-Moreira, Duncan J. Stewart and Shirley H. J. Mei
    Citation: Stem Cell Research & Therapy 2021 12:184
    Content type: Research Published on:

  8. Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chron...

    Authors: Yuan-chi Teng, Alfredo Leonardo Porfírio-Sousa, Giulia Magri Ribeiro, Marcela Corso Arend, Lindolfo da Silva Meirelles, Elizabeth Suchi Chen, Daniela Santoro Rosa and Sang Won Han
    Citation: Stem Cell Research & Therapy 2021 12:183
    Content type: Research Published on:

  9. Sjögren’s syndrome (SS) is a chronic autoimmune disease primarily characterized by inflammation in the salivary and lacrimal glands. Activated T cells contribute to disease pathogenesis by producing proinflamm...

    Authors: Mayu Matsumura-Kawashima, Kenichi Ogata, Masafumi Moriyama, Yuka Murakami, Tatsuya Kawado and Seiji Nakamura
    Citation: Stem Cell Research & Therapy 2021 12:182
    Content type: Research Published on:

  10. The bone marrow mesenchymal stem cell (BMSCs)-derived extracellular vesicles (EVs) open up a new avenue for ulcerative colitis (UC) treatment recently, but they are not selectively enriched in targeted tissues...

    Authors: Ting Yu, Si Chu, Xingxing Liu, Junyi Li, Qianyun Chen, Meng Xu, Hui Wu, Mingyue Li, Yalan Dong, Feng Zhu, Haifeng Zhou, Desheng Hu and Heng Fan
    Citation: Stem Cell Research & Therapy 2021 12:181
    Content type: Research Published on:

  11. Severe peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies ...

    Authors: Yang Zhang, Xiang Xu, Yuxin Tong, Xijie Zhou, Jian Du, In Young Choi, Shouwei Yue, Gabsang Lee, Blake N. Johnson and Xiaofeng Jia
    Citation: Stem Cell Research & Therapy 2021 12:180
    Content type: Research Published on:

  12. Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical...

    Authors: Zhuoqun Fang, Penghong Chen, Shijie Tang, Aizhen Chen, Chaoyu Zhang, Guohao Peng, Ming Li and Xiaosong Chen
    Citation: Stem Cell Research & Therapy 2021 12:179
    Content type: Review Published on:

  13. Premature ovarian insufficiency (POI) is one of the major causes of infertility. We previously demonstrated that transplantation of menstrual blood-derived stromal cells (MenSCs) effectively improved ovarian f...

    Authors: Siwen Zhang, Boxian Huang, Peng Su, Qiyuan Chang, Pingping Li, Aixin Song, Xinyang Zhao, Zhengwei Yuan and Jichun Tan
    Citation: Stem Cell Research & Therapy 2021 12:178
    Content type: Research Published on:

  14. Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs) inadequately recapitulate complete development and result in PSC-derived cardiomyocytes (PSC-CMs) with an immature or fe...

    Authors: Jessica C. Garbern and Richard T. Lee
    Citation: Stem Cell Research & Therapy 2021 12:177
    Content type: Review Published on:

  15. Obesity has received increasing attention because of its widespread worldwide occurrence and many threats to health. Human adipose-derived mesenchymal stem cells (hADSCs) are a critical source of adipocytes. L...

    Authors: Haoying Xu, Yanlei Yang, Linyuan Fan, Luchan Deng, Junfen Fan, Di Li, Hongling Li and Robert Chunhua Zhao
    Citation: Stem Cell Research & Therapy 2021 12:176
    Content type: Research Published on:

  16. Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is gradually becoming popular, particularly for early-s...

    Authors: Meiling Zhou, Jiaoya Xi, Yaofeng Cheng, Denglong Sun, Peng Shu, Shuiqing Chi, Shuo Tian and Shunan Ye
    Citation: Stem Cell Research & Therapy 2021 12:175
    Content type: Research Published on:

  17. Spinal cord injury (SCI) is a debilitating medical condition that can result in the irreversible loss of sensorimotor function. Current therapies fail to provide an effective recovery being crucial to develop ...

    Authors: Wenshu Zhou, Marta Silva, Chun Feng, Shumei Zhao, Linlin Liu, Shuai Li, Jingmei Zhong and Wenhua Zheng
    Citation: Stem Cell Research & Therapy 2021 12:174
    Content type: Research Published on:

  18. Osteoporosis (OP) is a metabolic bone disease due to the imbalance of osteogenesis and bone resorption, in which, bone marrow mesenchymal stem cells (BMSCs) have a significant effect as the seed cells. Recent ...

    Authors: Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2021 12:173
    Content type: Research Published on:

  19. Spinal cord injury (SCI) is a common disease that results in motor and sensory disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic stem cells (ESCs), induced pluripotent...

    Authors: Desheng Kong, Baofeng Feng, Asiamah Ernest Amponsah, Jingjing He, Ruiyun Guo, Boxin Liu, Xiaofeng Du, Xin Liu, Shuhan Zhang, Fei Lv, Jun Ma and Huixian Cui
    Citation: Stem Cell Research & Therapy 2021 12:172
    Content type: Research Published on:

  20. Renal interstitial fibrosis, an important pathological feature of kidney aging and chronic renal failure, is regulated by mesenchymal stem cells (MSCs). We have previously demonstrated low expression of miR-13...

    Authors: Dan Cao, Yuan Wang, Yingjie Zhang, Yinping Zhang, Qi Huang, Zhong Yin, Guangyan Cai, Xiangmei Chen and Xuefeng Sun
    Citation: Stem Cell Research & Therapy 2021 12:171
    Content type: Research Published on:

  21. Skin wounds in diabetic patients hardly recover. Accumulating evidence has shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived suppressor cells (MDSCs) are involved in inflammatory-rela...

    Authors: Yi Li, Yujun Xu, Xinghan Liu, Xin Yan, Yue Lin, Qian Tan and Yayi Hou
    Citation: Stem Cell Research & Therapy 2021 12:170
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:494

  22. New mechanistic insights into the self-renewal ability and multipotent properties of neural stem cells (NSCs) are currently under active investigation for potential use in the treatment of neurological disease...

    Authors: Jiaoying Jia, Yan Cui, Zhigang Tan, Min Liu and Yugang Jiang
    Citation: Stem Cell Research & Therapy 2021 12:169
    Content type: Research Published on:

  23. Retina diseases may lead to blindness as they often afflict both eyes. Stem cell transplantation into the affected eye(s) is a promising therapeutic strategy for certain retinal diseases. Human peripheral bloo...

    Authors: Jianfa Huang, Bikun Xian, Yuting Peng, Baozhu Zeng, Weihua Li, Zhiquan Li, Yaojue Xie, Minglei Zhao, Hening Zhang, Minyi Zhou, Huan Yu, Peixin Wu, Xing Liu and Bing Huang
    Citation: Stem Cell Research & Therapy 2021 12:168
    Content type: Research Published on:

  24. Brown adipocytes (BAs) are major components of brown adipose tissue (BAT), which is involved in blood pressure regulation. BAs are derived from multiple progenitors, including PDGFRα+ adipose-derived stem cells (...

    Authors: Wenda Xi, Wendong Chen, Weihong Sun, Xiangxiao Li, Zhimin Suo, Gonghao Jiang, Pingjin Gao and Qun Li
    Citation: Stem Cell Research & Therapy 2021 12:167
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:351

  25. Coronary artery disease (CAD) is the leading cause of death worldwide. Chromosome locus 9p21 was the first to be associated with increased risk of CAD and coronary artery calcification (CAC). Vascular calcific...

    Authors: Anja Trillhaase, Beatrice Schmidt, Marlon Märtens, Undine Haferkamp, Jeanette Erdmann and Zouhair Aherrahrou
    Citation: Stem Cell Research & Therapy 2021 12:166
    Content type: Research Published on:

  26. Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblas...

    Authors: Lingling Chen, Morgan Carlton, Xiaodan Chen, Navdeep Kaur, Hollie Ryan, Tony J Parker, Zhengmei Lin, Yin Xiao and Yinghong Zhou
    Citation: Stem Cell Research & Therapy 2021 12:165
    Content type: Research Published on:

  27. Mesenchymal stem cells (MSCs) are derived from multiple tissues, including amniotic fluid (AF-MSCs) and the umbilical cord (UC-MSCs). Although the therapeutic effect of MSCs on sepsis is already known, researc...

    Authors: Rui Chen, Yingjun Xie, Xuan Zhong, Fei Chen, Yu Gong, Na Wang and Ding Wang
    Citation: Stem Cell Research & Therapy 2021 12:164
    Content type: Research Published on:

  28. Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton’s jelly-derived mes...

    Authors: Yongjian Qi, Bin Li, Yinxian Wen, Xu Yang, Biao Chen, Zheng He, Zhe Zhao, Jacques Magdalou, Hui Wang and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2021 12:163
    Content type: Research Published on:

  29. Recovery of muscle function after peripheral nerve injury is often poor, and this can be attributed to muscle fiber atrophy and cell death. In the current study, we have investigated the effects of stromal vas...

    Authors: R. El-Habta, G. Andersson, P. J. Kingham and L. J. Backman
    Citation: Stem Cell Research & Therapy 2021 12:162
    Content type: Research Published on:

  30. Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level...

    Authors: Yun-Xing Fu, Jing Ji, Fang Shan, Jialing Li and Rong Hu
    Citation: Stem Cell Research & Therapy 2021 12:161
    Content type: Review Published on:

  31. Autologous fat grafting is often a crucial aspect of reconstructive and aesthetic surgeries, yet poor graft retention is a major issue with this technique. Enriching fat grafts with adipose tissue-derived mese...

    Authors: Richard J. P. Smith, Alessandro Faroni, James R. Barrow, Jamie Soul and Adam J. Reid
    Citation: Stem Cell Research & Therapy 2021 12:160
    Content type: Research Published on:

  32. Dental pulp stem cells (DPSCs) are a promising cell source in endodontic regeneration and tissue engineering with limited self-renewal and pluripotency capacity. N6-methyladenosine (m6A) is the most prevalent, re...

    Authors: Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu and Longquan Shao
    Citation: Stem Cell Research & Therapy 2021 12:159
    Content type: Research Published on:

  33. The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety...

    Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Dajin Chen, Jun Cheng, Jianyong Wu, Wenhan Peng and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2021 12:158
    Content type: Research Published on:

  34. As one of the most common chronic diseases in the world, osteoporosis occurs especially in postmenopausal women. Circular RNAs (circRNAs) are emerging as major drivers in human disease. The aim of the present ...

    Authors: Feng Zhi, Yi Ding, Rong Wang, Yujiao Yang, Kaiming Luo and Fei Hua
    Citation: Stem Cell Research & Therapy 2021 12:157
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:381

  35. Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, ca...

    Authors: Yu-kun Yang, Ye Li, Yan-ying Wang, Guang-ping Ruan, Chuan Tian, Qiang Wang, Huan-yu He, Gao-hong Zhu, Dong Fang, Mao Wang, Xiang-qing Zhu and Xing-hua Pan
    Citation: Stem Cell Research & Therapy 2021 12:156
    Content type: Research Published on:

  36. A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multi...

    Authors: Rodrigo N. Riedel, Antonio Pérez-Pérez, Víctor Sánchez-Margalet, Cecilia L. Varone and Julieta L. Maymó
    Citation: Stem Cell Research & Therapy 2021 12:155
    Content type: Review Published on:

  37. Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.

    Authors: Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li and De-Zhi Tang
    Citation: Stem Cell Research & Therapy 2021 12:154
    Content type: Research Published on:

  38. Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including immunosup...

    Authors: Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng and Yi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:153
    Content type: Research Published on:

  39. Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, assoc...

    Authors: Miryam Mebarki, Camille Abadie, Jérôme Larghero and Audrey Cras
    Citation: Stem Cell Research & Therapy 2021 12:152
    Content type: Review Published on:

  40. Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepa...

    Authors: Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao and Yin-xiong Li
    Citation: Stem Cell Research & Therapy 2021 12:151
    Content type: Research Published on:

  41. Little is known about the implications of circRNAs in the effects of melatonin (MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoporosis (OP) progression. The aim of our stu...

    Authors: Xudong Wang, Taiqiu Chen, Zhihuai Deng, Wenjie Gao, Tongzhou Liang, Xianjian Qiu, Bo Gao, Zizhao Wu, Jincheng Qiu, Yuanxin Zhu, Yanbo Chen, Zhancheng Liang, Hang Zhou, Caixia Xu, Anjing Liang, Peiqiang Su…
    Citation: Stem Cell Research & Therapy 2021 12:150
    Content type: Research Published on:

  42. Patients with coronary artery disease (CAD) are characterized by a decline in vascular regeneration, which is related to the dysfunction of endothelial progenitor cells (EPCs). G-protein-coupled receptor 4 (GP...

    Authors: Shun Ouyang, Yan Li, Xing Wu, Yan Wang, Fanmao Liu, Jianning Zhang, Yumin Qiu, Zhe Zhou, Zhichao Wang, Wenhao Xia and Xiufang Lin
    Citation: Stem Cell Research & Therapy 2021 12:149
    Content type: Research Published on:

  44. Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients...

    Authors: Linli Shi, Qian Han, Yimei Hong, Weifeng Li, Gencheng Gong, Jiangyu Cui, Mengmeng Mao, Xiaoting Liang, Bei Hu, Xin Li, Qun Luo and Yuelin Zhang
    Citation: Stem Cell Research & Therapy 2021 12:147
    Content type: Research Published on:

  45. Muscle is severely affected by ischemia/reperfusion injury (IRI). Quiescent satellite cells differentiating into myogenic progenitor cells (MPC) possess a remarkable regenerative potential. We herein establish...

    Authors: Franka Messner, Marco Thurner, Jule Müller, Michael Blumer, Julia Hofmann, Rainer Marksteiner, Sebastien Couillard-Despres, Jakob Troppmair, Dietmar Öfner, Stefan Schneeberger and Theresa Hautz
    Citation: Stem Cell Research & Therapy 2021 12:146
    Content type: Research Published on:

  46. Endothelial progenitor cells (EPCs) are promising candidates for the cellular therapy of peripheral arterial and cardiovascular diseases. However, hitherto there is no specific marker(s) defining precisely EPC...

    Authors: Mohamed Essameldin Abdelgawad, Christophe Desterke, Georges Uzan and Sina Naserian
    Citation: Stem Cell Research & Therapy 2021 12:145
    Content type: Research Published on:

  47. Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies hav...

    Authors: Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck and Gábor Szabó
    Citation: Stem Cell Research & Therapy 2021 12:144
    Content type: Research Published on:

  48. As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate and involves many types of placental cells, such as trophob...

    Authors: Haiying Ma, Shenglu Jiang, Lili Du, Jinfang Liu, Xiaoyan Xu, Xiaomei Lu, Ling Ma, Hua Zhu, Jun Wei and Yanqiu Yu
    Citation: Stem Cell Research & Therapy 2021 12:141
    Content type: Research Published on:

  49. Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-directional differentiation, and paracrine and immune regulation. As a result of these properties, the MSCs have great clinical...

    Authors: Wanhao Yan, Shu Diao and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2021 12:140
    Content type: Review Published on:

  50. Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellul...

    Authors: Yi Yu, Alejandra Vargas Valderrama, Zhongchao Han, Georges Uzan, Sina Naserian and Estelle Oberlin
    Citation: Stem Cell Research & Therapy 2021 12:138
    Content type: Research Published on:
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