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  1. Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated wit...

    Authors: Lu Li, Yikai Wang, Xiaobing Yu, Yongming Bao, Lijia An, Xiaowei Wei, Weiting Yu, Baoyi Liu, Junlei Li, Jiahui Yang, Yan Xia, Ge Liu, Fang Cao, Xiuzhi Zhang and Dewei Zhao
    Citation: Stem Cell Research & Therapy 2020 11:480
    Content type: Research Published on:

  2. Idiopathic pulmonary fibrosis is a kind of diffuse interstitial lung disease, the pathogenesis of which is unclear, and there is currently a lack of good treatment to improve the survival rate. Human menstrual...

    Authors: Xin Chen, Yi Wu, Yanling Wang, Lijun Chen, Wendi Zheng, Sining Zhou, Huikang Xu, Yifei Li, Li Yuan and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2020 11:477
    Content type: Research Published on:

  3. Dentigerous cyst (DC) is a bone destructive disease and remains a challenge for clinicians. Marsupialization enables the bone to regenerate with capsule maintaining, making it a preferred therapeutic means for...

    Authors: Yejia Yu, Mengyu Li, Yuqiong Zhou, Yueqi Shi, Wenjie Zhang, Geehun Son, Jing Ge, Jun Zhao, Zhiyuan Zhang, Dongxia Ye, Chi Yang and Shaoyi Wang
    Citation: Stem Cell Research & Therapy 2020 11:476
    Content type: Research Published on:

  4. Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is constantly emerging. Over the past 20 yea...

    Authors: Yang Zhang, Min Ni, Chungen Zhou, Yehuang Wang, Yaxian Wang, Yang Shi, Jing Jin, Rui Zhang and Bin Jiang
    Citation: Stem Cell Research & Therapy 2020 11:475
    Content type: Research Published on:

  5. Small molecule compounds have been well recognized for their promising power in the generation, expansion, and maintenance of embryonic or adult stem cells. The aim of this study was to identify a novel combin...

    Authors: Morteza Zarrabi, Elaheh Afzal, Mohammad Hassan Asghari and Marzieh Ebrahimi
    Citation: Stem Cell Research & Therapy 2020 11:474
    Content type: Research Published on:

  6. After traumatic skeletal muscle injury, muscle healing is often incomplete and produces extensive fibrosis. The sequence of M1 and M2 macrophage accumulation and the duration of each subtype in the injured are...

    Authors: Leonardo Martins, Camila Congentino Gallo, Tâmisa Seeko Bandeira Honda, Patrícia Terra Alves, Roberta Sessa Stilhano, Daniela Santoro Rosa, Timothy Jon Koh and Sang Won Han
    Citation: Stem Cell Research & Therapy 2020 11:473
    Content type: Research Published on:

  7. Aging has detrimental effects on the ovary, such as a progressive reduction in fertility and decreased hormone production, that greatly reduce the quality of life of women. Thus, the current study was undertak...

    Authors: Kyeoung-Hwa Kim, Eun-Young Kim, Gi Jin Kim, Jung-Jae Ko, Kwang Yul Cha, Mi Kyung Koong and Kyung-Ah Lee
    Citation: Stem Cell Research & Therapy 2020 11:472
    Content type: Research Published on:

  8. Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cells, were identified as an attractive candidate for immunoregulation and induction of cardiac allograft tolerance. However, the un...

    Authors: Yiming Zhao, Xiang Li, Dingding Yu, Yonghao Hu, Wang Jin, Yafei Qin, Dejun Kong, Hongda Wang, Guangming Li, Alessandro Alessandrini and Hao Wang
    Citation: Stem Cell Research & Therapy 2020 11:471
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:150

  9. Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan—increasing clinical case repor...

    Authors: Rui Liu, Dong Li, Fangxu Sun, Antonio Rampoldi, Joshua T. Maxwell, Ronghu Wu, Peter Fischbach, Sharon M. Castellino, Yuhong Du, Haian Fu, Anant Mandawat and Chunhui Xu
    Citation: Stem Cell Research & Therapy 2020 11:470
    Content type: Research Published on:

  10. Placenta-derived mesenchymal stem cells (PD-MSCs) have unique immunomodulatory properties. Phosphatase of regenerating liver-1 (PRL-1) regulates the self-renewal ability of stem cells and promotes proliferatio...

    Authors: Jae Yeon Kim, Sohae Park, Hyun-Jung Lee, Helen Lew and Gi Jin Kim
    Citation: Stem Cell Research & Therapy 2020 11:469
    Content type: Research Published on:

  11. Mesenchymal stem cells (MSCs) were considered a regenerative therapeutic approach in both acute and chronic diseases. However, whether MSCs regulate the antioxidant metabolism of CD4+ T cells and weaken immunosen...

    Authors: Yanlian Xiong, Yueming Wang, Jiashen Zhang, Nannan Zhao, Hengchao Zhang, Aiping Zhang, Dongmei Zhao, Zhenhai Yu, Yancun Yin, Lele Song, Yanlei Xiong and Xiying Luan
    Citation: Stem Cell Research & Therapy 2020 11:468
    Content type: Research Published on:

  12. Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits vari...

    Authors: Taeui Hong, Moon Young Kim, Dat Da Ly, Su Jung Park, Young Woo Eom, Kyu-Sang Park and Soon Koo Baik
    Citation: Stem Cell Research & Therapy 2020 11:467
    Content type: Short report Published on:

  13. Premature ovarian insufficiency (POI) is an ovarian dysfunction that seriously affects a woman’s physiological health and reproduction. Mesenchymal stem cell (MSC) transplantation offers a promising treatment ...

    Authors: Yan Zhao, Jiao Ma, Peiye Yi, Jun Wu, Feiyan Zhao, Wan Tu, Wenjing Liu, Tianda Li, Yan Deng, Jie Hao, Hongmei Wang and Long Yan
    Citation: Stem Cell Research & Therapy 2020 11:466
    Content type: Research Published on:

  14. Inflammatory smooth muscle cells (iSMCs) generated from adventitial stem/progenitor cells (AdSPCs) have been recognised as a new player in cardiovascular disease, and microRNA-214-3p (miR-214-3p) has been impl...

    Authors: Shiping He, Feng Yang, Mei Yang, Weiwei An, Eithne Margaret Maguire, Qishan Chen, Rui Xiao, Wei Wu, Li Zhang, Wen Wang and Qingzhong Xiao
    Citation: Stem Cell Research & Therapy 2020 11:465
    Content type: Research Published on:

  15. The aim of this study was to determine whether the combination of MSC implantation with miRNA-126-3p overexpression would further improve the surgical results after vein grafting.

    Authors: Qingxi Qu, Limei Wang, Weidong Bing, Yanwen Bi, Chunmei Zhang, Xuanxuan Jing and Linghong Liu
    Citation: Stem Cell Research & Therapy 2020 11:464
    Content type: Research Published on:

  16. Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness. The two most prevalent forms of CMD, collagen VI-related ...

    Authors: Vitali Alexeev, Jacquelyn Olavarria, Paolo Bonaldo, Luciano Merlini and Olga Igoucheva
    Citation: Stem Cell Research & Therapy 2020 11:463
    Content type: Research Published on:

  17. Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells ...

    Authors: Maitane Ortiz-Virumbrales, Ramón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa and Eleuterio Lombardo
    Citation: Stem Cell Research & Therapy 2020 11:462
    Content type: Research Published on:

  18. Osteogenesis is a complex biological process which requires the coordination of multiple molecular mechanisms. This research aimed to explore the biological role and underlying regulatory mechanism of circSIPA...

    Authors: Yuzhi Li, Minxia Bian, Zhou Zhou, Xiao Wu, Xingyun Ge, Tong Xiao and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2020 11:461
    Content type: Research Published on:

  19. Adipose-derived stem cells (ADSCs) promote tissue regeneration and repair. Cryoprotective agents (CPAs) protect cells from cryodamage during cryopreservation. Safe and efficient cryopreservation of ADSCs is cr...

    Authors: Tian-Yu Zhang, Poh-Ching Tan, Yun Xie, Xiao-Jie Zhang, Pei-Qi Zhang, Yi-Ming Gao, Shuang-Bai Zhou and Qing-Feng Li
    Citation: Stem Cell Research & Therapy 2020 11:460
    Content type: Research Published on:

  21. Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Addition...

    Authors: Gang Fang, Xiaolang Jiang, Yuan Fang, Tianyue Pan, Hao Liu, Bichen Ren, Zheng Wei, Shiyang Gu, Bin Chen, Junhao Jiang, Yun Shi, Daqiao Guo, Peng Liu, Weiguo Fu and Zhihui Dong
    Citation: Stem Cell Research & Therapy 2020 11:458
    Content type: Research Published on:

  22. Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typin...

    Authors: Chaozhi Tang, Jiakang Ma, Xiuli Liu and Zhengchun Liu
    Citation: Stem Cell Research & Therapy 2020 11:457
    Content type: Research Published on:

  23. Efficient osteogenic differentiation of mesenchymal stem cells (MSCs) is a critical step in the treatment of bone defects and skeletal disorders, which present challenges for cell-based therapy and regenerativ...

    Authors: Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad
    Citation: Stem Cell Research & Therapy 2020 11:456
    Content type: Review Published on:

  24. Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microR...

    Authors: Feng Ding, Jinhua Liu and Xiaofei Zhang
    Citation: Stem Cell Research & Therapy 2020 11:455
    Content type: Research Published on:

  25. Human hair follicle mesenchymal stem cells (hHFMSCs) isolated from hair follicles possess multilineage differentiation potential. OCT4 is a gene critically associated with pluripotency properties. The cell mor...

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu
    Citation: Stem Cell Research & Therapy 2020 11:454
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:61

  26. Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration...

    Authors: C. Eguizabal, L. Herrera, M. Inglés-Ferrándiz and J. C. Izpisua Belmonte
    Citation: Stem Cell Research & Therapy 2020 11:453
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:250

  27. We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ...

    Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl
    Citation: Stem Cell Research & Therapy 2020 11:330
    Content type: Research Published on:

  28. Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve w...

    Authors: Mengna Duan, Yan Zhang, Haiyang Zhang, Yupeng Meng, Ming Qian and Guokun Zhang
    Citation: Stem Cell Research & Therapy 2020 11:452
    Content type: Research Published on:

  29. Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic ...

    Authors: Angelo Trivisonno, Dania Nachira, Ivo Boškoski, Venanzio Porziella, Giuliana Di Rocco, Silvia Baldari and Gabriele Toietta
    Citation: Stem Cell Research & Therapy 2020 11:451
    Content type: Review Published on:

  31. Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor o...

    Authors: Defu Kong, Huiming Xu, Mo Chen, Yeping Yu, Yongbing Qian, Tian Qin, Ying Tong, Qiang Xia and Hualian Hang
    Citation: Stem Cell Research & Therapy 2020 11:449
    Content type: Research Published on:

  32. Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene deli...

    Authors: Helena Meyer-Berg, Lucia Zhou Yang, María Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde and Deborah R. Gill
    Citation: Stem Cell Research & Therapy 2020 11:448
    Content type: Short report Published on:

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:446
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:340

  35. Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with no effective therapies to slow its progression. Several studies have reported short-term efficacy of stem cells on early-stage ONFH...

    Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Chenlie Ni, Yiming Zhang, Bing Zhang, Qiping Zheng and Dapeng Li
    Citation: Stem Cell Research & Therapy 2020 11:445
    Content type: Review Published on:

  36. Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t...

    Authors: Fangcao Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai and Guangwen Yin
    Citation: Stem Cell Research & Therapy 2020 11:444
    Content type: Research Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rossella Crescitelli and Helena Brisby
    Citation: Stem Cell Research & Therapy 2020 11:443
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:323

  38. Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the u...

    Authors: Chongxi Fan, Jianyu Feng, Chi Tang, Zhengbin Zhang, Yingtong Feng, Weixun Duan, Mingming Zhai, Zedong Yan, Liwen Zhu, Lele Feng, Hanzhao Zhu and Erping Luo
    Citation: Stem Cell Research & Therapy 2020 11:442
    Content type: Research Published on:

  39. Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays...

    Authors: Yang Li, Kangkang Zhi, Shilong Han, Xue Li, Maoquan Li, Weishuai Lian, Haijun Zhang and Xiaoping Zhang
    Citation: Stem Cell Research & Therapy 2020 11:441
    Content type: Research Published on:

  40. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) ch...

    Authors: Ahui Song, Jingjing Wang, Yan Tong, Junyan Fang, Yi Zhang, Huiping Zhang, Hongqiang Ruan, Kai Wang and Yingli Liu
    Citation: Stem Cell Research & Therapy 2020 11:440
    Content type: Research Published on:

  42. Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing ...

    Authors: Yue Zhang, Fanhong Zeng, Xu Han, Jun Weng and Yi Gao
    Citation: Stem Cell Research & Therapy 2020 11:438
    Content type: Review Published on:

  43. The COVID-19 pandemic has negatively impacted the global public health and the international economy; therefore, there is an urgent need for an effective therapy to treat COVID-19 patients. Mesenchymal stem ce...

    Authors: Sara Al-Khawaga and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2020 11:437
    Content type: Review Published on:

  44. Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation...

    Authors: Shahrbanoo Jahangir, David Eglin, Naomi Pötter, Mojtaba Khozaei Ravari, Martin J. Stoddart, Ali Samadikuchaksaraei, Mauro Alini, Mohammadreza Baghaban Eslaminejad and Majid Safa
    Citation: Stem Cell Research & Therapy 2020 11:436
    Content type: Research Published on:

  45. The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate of transplanted BMSCs in woun...

    Authors: Ling Guo, Juan Du, Dan-feng Yuan, Ya Zhang, Shu Zhang, Hua-cai Zhang, Jun-wei Mi, Ya-lei Ning, Min-jia Chen, Da-lin Wen, Jian-hui Sun, Di Liu, Ling Zeng, Anqiang Zhang, Jianxin Jiang and Hong Huang
    Citation: Stem Cell Research & Therapy 2020 11:434
    Content type: Research Published on:

  47. Current strategies for craniofacial defect are faced with unmet outcome. Combining 3D-printing with safe, noninvasive magnetic therapy could be a promising breakthrough.

    Authors: Chang Tu, Jingyuan Chen, Chunwei Huang, Yifan Xiao, Xiangyu Tang, Hao Li, Yongzhuang Ma, Jiyuan Yan, Weigang Li, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2020 11:433
    Content type: Research Published on:

  48. The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising re...

    Authors: Silvia Palombella, Martino Guiotto, Gillian C. Higgins, Laurent L. Applegate, Wassim Raffoul, Mario Cherubino, Andrew Hart, Mathis O. Riehle and Pietro G. di Summa
    Citation: Stem Cell Research & Therapy 2020 11:432
    Content type: Research Published on:

  49. Stem cell transplantation has been proposed as an alternative treatment for intractable optic nerve disorders characterized by irrecoverable loss of cells. Mesenchymal stem cells, with varying tissue regenerat...

    Authors: Kyungmin Koh, Mira Park, Eun Soo Bae, Van-An Duong, Jong-Moon Park, Hookeun Lee and Helen Lew
    Citation: Stem Cell Research & Therapy 2020 11:428
    Content type: Research Published on:

  50. Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive compa...

    Authors: Qiang Li, Guangwen Yang, Jialing Li, Meng Ding, Na Zhou, Heng Dong and Yongbin Mou
    Citation: Stem Cell Research & Therapy 2020 11:427
    Content type: Research Published on:
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