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  1. Cutaneous wound healing represents a morphogenetic response to injury and is designed to restore anatomic and physiological function. Human bone marrow mesenchymal stem cell-derived exosomes (hBM-MSC-Ex) are a...

    Authors: Tiechao Jiang, Zhongyu Wang and Ji Sun

    Citation: Stem Cell Research & Therapy 2020 11:198

    Content type: Research

    Published on:

  2. The inevitable side effects caused by lifelong immunosuppressive agents in kidney transplantation patients spurred the exploration of novel immunosuppressive strategies with definite curative effects and minim...

    Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Fanghao Cai, Junni Wang and Jianghua Chen

    Citation: Stem Cell Research & Therapy 2020 11:197

    Content type: Review

    Published on:

  3. Mesendodermal formation during early gastrulation requires the expression of lineage-specific genes, while the regulatory mechanisms during this process have not yet been fully illustrated. TATA box-binding pr...

    Authors: He Liang, Peng Zhang, Hua-Jun Bai, Jijun Huang and Huang-Tian Yang

    Citation: Stem Cell Research & Therapy 2020 11:196

    Content type: Research

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  4. RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers. This protein is a crit...

    Authors: Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani, Ali Osmay Gure and Kamran Ghaedi

    Citation: Stem Cell Research & Therapy 2020 11:193

    Content type: Review

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  5. Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity...

    Authors: Jiang Du, Han Li, Jie Lian, Xinxing Zhu, Liang Qiao and Juntang Lin

    Citation: Stem Cell Research & Therapy 2020 11:192

    Content type: Review

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  6. Some children who have survived cancer will be azoospermic in the future. Performing isolation and purification procedures for spermatogonial stem cells (SSC) is very critical. In this regard, performing the p...

    Authors: Behnaz Ashtari, Azar Shams, Narges Esmaeilzadeh, Sara Tanbakooei, Morteza Koruji, Mojtaba Johari Moghadam, Javad Mohajer Ansari, Adel Johari Moghadam and Ronak Shabani

    Citation: Stem Cell Research & Therapy 2020 11:191

    Content type: Research

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Orianne Villard, Mathieu Armanet, Guilhem Couderc, Claire Bony, Jerome Moreaux, Daniele Noël, John De Vos, Bernard Klein, Jean-Luc Veyrune and Anne Wojtusciszyn

    Citation: Stem Cell Research & Therapy 2020 11:190

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:158

  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yong Yao, Liang Yang, Li-feng Feng, Zhi-wei Yue, Nian-huan Zhao, Zongjin Li and Zuo-xiang He

    Citation: Stem Cell Research & Therapy 2020 11:189

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:136

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chen-Fei Zhou, Min-Juan Liu, Wei Wang, Sha Wu, Yu-Xin Huang, Guo-Bin Chen, Li-Min Liu, Dong-Xian Peng, Xue-Feng Wang, Xu-Zi Cai, Xiao-Xuan Li, Wan-Qin Feng and Ying Ma

    Citation: Stem Cell Research & Therapy 2020 11:188

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:287

  10. Similar to humans, the horse is a long-lived, athletic species. The use of mesenchymal stromal cells (MSCs) is a relatively new frontier, but has been used with promising results in treating joint diseases, e....

    Authors: Louise Bundgaard, Allan Stensballe, Kirstine Juul Elbæk and Lise Charlotte Berg

    Citation: Stem Cell Research & Therapy 2020 11:187

    Content type: Research

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  11. The therapeutic effects of mesenchymal stem cells (MSCs) have been limited by their apoptosis induced by oxidative stress after delivery into the injured sites. Therefore, strategies designed to improve the MS...

    Authors: Lianshuang Zhang, Xifeng Wang, Xueyan Lu, Yanchao Ma, Xin Xin, Xiaomin Xu, Siyuan Wang and Yun Hou

    Citation: Stem Cell Research & Therapy 2020 11:186

    Content type: Research

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  12. Human induced pluripotent stem cells (hiPSCs) represent a potentially unlimited source of pancreatic endocrine lineage cells. Although insulin-producing β cells derived from hiPSCs have been successfully induc...

    Authors: Xiao-Fei Yang, Shu-Yan Zhou, Ce Wang, Wei Huang, Ning Li, Fei He and Fu-Rong Li

    Citation: Stem Cell Research & Therapy 2020 11:185

    Content type: Research

    Published on:

  13. Tendon injuries occur frequently in human and equine athletes. Treatment options are limited, and the prognosis is often poor with functionally deficient scar tissue resulting. Fetal tendon injuries in contras...

    Authors: Y. Z. Paterson, A. Cribbs, M. Espenel, E. J. Smith, F. M. D. Henson and D. J. Guest

    Citation: Stem Cell Research & Therapy 2020 11:184

    Content type: Research

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  14. Mesenchymal stem cells (MSCs) are considered to be an effective tool for regenerative medicine with promising applications for clinical therapy. However, incongruent data has been reported partially owing to t...

    Authors: Xiao Yi, Feng Chen, Fenghua Liu, Qing Peng, Yang Li, Shao Li, Jiang Du, Yi Gao and Yifeng Wang

    Citation: Stem Cell Research & Therapy 2020 11:183

    Content type: Research

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  15. ARDS and ALI are life-threatening diseases with extremely high mortality in patients. Different sources of MSCs could mitigate the symptoms of ALI from diverse mechanisms. Liraglutide is an activator of glucag...

    Authors: Xiaotong Yang, Xiaoying Ma, Ocholi Don, Yuanlin Song, Xiaoyan Chen, Jianwen Liu, Jieming Qu and Yun Feng

    Citation: Stem Cell Research & Therapy 2020 11:182

    Content type: Research

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  16. The dedifferentiation of chondrocytes and the unstable chondrogenic differentiation status of pluripotent mesenchymal stem cells (MSCs) are immense issues in cell-based articular cartilage repair and regenerat...

    Authors: Yu Zhang, Chunxiang Hao, Weimin Guo, Xiaoyu Peng, Mingjie Wang, Zhen Yang, Xu Li, Xueliang Zhang, Mingxue Chen, Xiang Sui, Jiang Peng, Shibi Lu, Shuyun Liu, Quanyi Guo and Qing Jiang

    Citation: Stem Cell Research & Therapy 2020 11:180

    Content type: Research

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  17. Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 ge...

    Authors: Xiaojie Xian, Roksana Moraghebi, Henrik Löfvall, Anders Fasth, Kim Henriksen, Johan Richter, Niels-Bjarne Woods and Ilana Moscatelli

    Citation: Stem Cell Research & Therapy 2020 11:179

    Content type: Research

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  18. Mesenchymal stem cells (MSCs) have become a promising treatment for spinal cord injury (SCI) due to the fact that they provide a favorable environment. Treatment using MSCs results in a better neurological fun...

    Authors: Peiwen Song, Tianyu Han, Xia Xiang, Ying Wang, Huang Fang, Yang Niu and Cailiang Shen

    Citation: Stem Cell Research & Therapy 2020 11:178

    Content type: Research

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  19. Since cartilage-derived stem/progenitor cells (CSPCs) were first identified in articular cartilage using differential adhesion to fibronectin, their self-renewal capacity and niche-specific lineage preference ...

    Authors: Zita M. Jessop, Ayesha Al-Sabah, Irina N. Simoes, Stephanie E. A. Burnell, Ina Laura Pieper, Catherine A. Thornton and Iain S. Whitaker

    Citation: Stem Cell Research & Therapy 2020 11:177

    Content type: Research

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  20. Cell-based therapy products are supposed to be the most complex medicine products in the history of human medical care. In this study, we established a safety evaluation system for therapeutic stromal cells ba...

    Authors: Yuanyuan Xie, Wei Liu, Shuo Liu, Liudi Wang, Dan Mu, Yi Cui, Yanyan Cui and Bin Wang

    Citation: Stem Cell Research & Therapy 2020 11:176

    Content type: Research

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  21. Advances in regenerative medicine with stem cells have led to clinical trials. Dental/oral tissues are emerging as promising cellular sources of human mesenchymal stem cells. Recently, dental tissue-derived ce...

    Authors: Yoichi Yamada, Sayaka Nakamura-Yamada, Ryutaro Konoki and Shunsuke Baba

    Citation: Stem Cell Research & Therapy 2020 11:175

    Content type: Review

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  22. Skin wounding is very common and may be slow to heal. Increasing evidence shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance skin wound healing in a paracrine manner. However, ...

    Authors: Guifang Zhao, Feilin Liu, Zinan Liu, Kuiyang Zuo, Bo Wang, Yuying Zhang, Xing Han, Aobo Lian, Yuan Wang, Mingsheng Liu, Fei Zou, Pengdong Li, Xiaomei Liu, Minghua Jin and Jin Yu Liu

    Citation: Stem Cell Research & Therapy 2020 11:174

    Content type: Research

    Published on:

  23. A commentary to “Hertegård, S., Nagubothu, S.R., Malmström, E. et al. Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I/II human clinical stud...

    Authors: Alexia Mattei, Jérémy Magalon, Mélanie Velier, Françoise Dignat-George, Antoine Giovanni and Florence Sabatier

    Citation: Stem Cell Research & Therapy 2020 11:173

    Content type: Commentary

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:128

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:235

  24. Cardiovascular diseases are the main cause of morbidity and mortality worldwide. Restoring blood supply to ischemic tissues is an essential goal for the successful treatment of these diseases. Growth factor or...

    Authors: Richard Proust, Anne-Charlotte Ponsen, Valérie Rouffiac, Chantal Schenowitz, Florent Montespan, Karine Ser-Le Roux, Frédéric De Leeuw, Corinne Laplace-Builhé, Philippe Mauduit, Edgardo D. Carosella, Sébastien Banzet, Jean-Jacques Lataillade, Nathalie Rouas-Freiss, Georges Uzan and Juliette Peltzer

    Citation: Stem Cell Research & Therapy 2020 11:172

    Content type: Research

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  25. Rheumatoid arthritis (RA) is characterized by joint inflammation and damage to the cartilage and bone in collagen-induced arthritis (CIA). Mesenchymal stem cells (MSCs) can improve articular symptoms and reduc...

    Authors: Jinfang Gao, Gailian Zhang, Ke Xu, Dan Ma, Limin Ren, Jingjing Fan, Jianwen Hou, Jian Han and Liyun Zhang

    Citation: Stem Cell Research & Therapy 2020 11:171

    Content type: Research

    Published on:

  26. Cancer stem cells (CSCs) have been proposed to be responsible for tumor recurrence and chemo-resistance. Previous studies suggested that miR-153 played essential roles in lung cancer. However, the molecular me...

    Authors: Guoli Zhao, Yueying Zhang, Zhonghua Zhao, Haibo Cai, Xiaogang Zhao, Tong Yang, Weijun Chen, Chengfang Yao, Zhaopeng Wang, Zhaoxia Wang, Chen Han and Hengxiao Wang

    Citation: Stem Cell Research & Therapy 2020 11:170

    Content type: Research

    Published on:

  27. The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are sc...

    Authors: Shan Liu, Danyi Peng, Huijun Qiu, Ke Yang, Zhou Fu and Lin Zou

    Citation: Stem Cell Research & Therapy 2020 11:169

    Content type: Commentary

    Published on:

  28. Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available.

    Authors: Cristian De Gregorio, David Contador, Diego Díaz, Constanza Cárcamo, Daniela Santapau, Lorena Lobos-Gonzalez, Cristian Acosta, Mario Campero, Daniel Carpio, Caterina Gabriele, Marco Gaspari, Victor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Marcelo Ezquer and Fernando Ezquer

    Citation: Stem Cell Research & Therapy 2020 11:168

    Content type: Research

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  29. Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and lon...

    Authors: Fabio S. Aguiar, André S. Melo, Ana Maria S. Araújo, Alexandre P. Cardoso, Sergio Augusto L. de Souza, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Debora G. Xisto, Karina D. Asensi, Lanuza Faccioli, Anna Beatriz S. Salgado, Maria Carolina P. P. Landesmann, Regina C. S. Goldenberg, Bianca Gutfilen, Marcelo M. Morales, Patricia R. M. Rocco…

    Citation: Stem Cell Research & Therapy 2020 11:167

    Content type: Research

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  30. Fibroblasts are crucial for supporting normal wound healing. However, the functional state of these cells is impaired in diabetics because of a high-glucose (HG) microenvironment. Small extracellular vesicles ...

    Authors: Xiaowei Bian, Bingmin Li, Jie Yang, Kui Ma, Mengli Sun, Cuiping Zhang and Xiaobing Fu

    Citation: Stem Cell Research & Therapy 2020 11:166

    Content type: Research

    Published on:

  31. Mesenchymal stromal cell (MSC)-enriched products showed positive clinical outcomes in regenerative medicine, where tissue restoration and inflammation control are needed. GMP-expanded MSCs displayed an even hi...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Carlotta Mondadori, Marco Viganò, Alessandra Colombini and Laura de Girolamo

    Citation: Stem Cell Research & Therapy 2020 11:165

    Content type: Research

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  32. CD18 is the common beta subunit of β2 integrins, which are expressed on hematopoietic cells. β2 integrins are essential for cell adhesion and leukocyte trafficking.

    Authors: Cristina Mesa-Núñez, Diego Leon-Rico, Montserrat Aldea, Carlos Damián, Raquel Sanchez-Baltasar, Rebeca Sanchez, Omaira Alberquilla, José Carlos Segovia, Juan Antonio Bueren and Elena Almarza

    Citation: Stem Cell Research & Therapy 2020 11:164

    Content type: Research

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  33. Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem ...

    Authors: Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang and Fu-Rong Li

    Citation: Stem Cell Research & Therapy 2020 11:163

    Content type: Research

    Published on:

  34. M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. However, the possible synergistic effects between exogenous exosomes and endogenous M2 macrophages ...

    Authors: Dihan Zhu, Takerra K. Johnson, Yang Wang, Miracle Thomas, Ky Huynh, Qinglin Yang, Vincent C. Bond, Y. Eugene Chen and Dong Liu

    Citation: Stem Cell Research & Therapy 2020 11:162

    Content type: Research

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  35. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to have therapeutic potential for ischemic diseases and are considered an alternative to cell therapy. However, the low retentio...

    Authors: Yue Liu, Jian Cui, Hongfen Wang, Kamal Hezam, Xiaotong Zhao, Haoyan Huang, Shang Chen, Zhibo Han, Zhong-Chao Han, Zhikun Guo and Zongjin Li

    Citation: Stem Cell Research & Therapy 2020 11:161

    Content type: Research

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  36. Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of rad...

    Authors: Linqing Zou, Haoming Li, Xiao Han, Jianbing Qin and Guoqi Song

    Citation: Stem Cell Research & Therapy 2020 11:160

    Content type: Research

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  37. Human amniotic epithelial cell (hAEC) transplantation holds great promise in treating premature ovarian insufficiency (POI). However, some deficient biological characteristics of hAECs restrict their application.

    Authors: Shunyu Hou, Chenyue Ding, Han Shen, Chunfeng Qian, Qinyan Zou, Jiafeng Lu, Boxian Huang, Jichun Tan and Hong Li

    Citation: Stem Cell Research & Therapy 2020 11:159

    Content type: Research

    Published on:

  38. Mesenchymal stromal cells (MSCs) represent an interesting tool to improve pancreatic islet transplantation. They have immunomodulatory properties and secrete supportive proteins. However, the functional proper...

    Authors: Orianne Villard, Mathieu Armanet, Guilhem Couderc, Claire Bony, Jerome Moreaux, Daniele Noël, John DeVos, Bernard Klein, Jean-Luc Veyrune and Anne Wojtusciszyn

    Citation: Stem Cell Research & Therapy 2020 11:158

    Content type: Research

    Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:190

  39. The development of somatic reprogramming, especially purely chemical reprogramming, has significantly advanced biological research. And chemical-induced extraembryonic endoderm-like (ciXEN) cells have been con...

    Authors: Xia He, Guangfan Chi, Meiying Li, Jinying Xu, Lihong Zhang, Yaolin Song, Lina Wang and Yulin Li

    Citation: Stem Cell Research & Therapy 2020 11:157

    Content type: Research

    Published on:

  40. Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of ...

    Authors: Amandda Évelin Silva-Carvalho, Leane Perim Rodrigues, Josiane Lilian Schiavinato, Marcos Rodrigo Alborghetti, Gustavo Bettarello, Belinda Pinto Simões, Francisco de Assis Rocha Neves, Rodrigo Alexandre Panepucci, Juliana Lott de Carvalho and Felipe Saldanha-Araujo

    Citation: Stem Cell Research & Therapy 2020 11:156

    Content type: Research

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  41. The limited neuronal differentiation of the endogenous or grafted neural stem cells (NSCs) after brain injury hampers the clinic usage of NSCs. Panax notoginseng saponins (PNS) were extensively used for their cli...

    Authors: Liu-Lin Xiong, De-Lu Qiu, Guang-Hui Xiu, Mohammed Al-Hawwas, Ya Jiang, You-Cui Wang, Yue Hu, Li Chen, Qing-Jie Xia and Ting-Hua Wang

    Citation: Stem Cell Research & Therapy 2020 11:155

    Content type: Research

    Published on:

  42. Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver...

    Authors: Iasmim Diniz Orge, Victoria L. Gadd, Judah Leão Barouh, Erik Aranha Rossi, Rejane Hughes Carvalho, Ian Smith, Kyan James Allahdadi, Bruno Diaz Paredes, Daniela Nascimento Silva, Patrícia Kauanna F. Damasceno, Gabriela Louise Sampaio, Stuart J. Forbes, Milena Botelho Pereira Soares and Bruno Solano de Freitas Souza

    Citation: Stem Cell Research & Therapy 2020 11:154

    Content type: Research

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  43. To date, it has repeatedly been demonstrated that infusing bone marrow-derived stem cells (BMSCs) into acellular nerve scaffolds can promote and support axon regeneration through a peripheral nerve defect. How...

    Authors: Li Na Zhou, Jia Chuan Wang, Prince Last Mudenda Zilundu, Ya Qiong Wang, Wen Ping Guo, Sai Xia Zhang, Hui Luo, Jian Hong Zhou, Ru Dong Deng and Dong Feng Chen

    Citation: Stem Cell Research & Therapy 2020 11:153

    Content type: Research

    Published on:

  44. Chronic rhinosinusitis (CRS) is characterized by persistent symptomatic inflammation of the nasal passage and sinus mucosa. Various microRNAs (miRs) have been implicated in CRS. Hence, the current study was co...

    Authors: Jinzhang Cheng, Junjun Chen, Yin Zhao, Jingpu Yang, Kai Xue and Zonggui Wang

    Citation: Stem Cell Research & Therapy 2020 11:151

    Content type: Research

    Published on:

  45. Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue r...

    Authors: Xiu-Ru Zhang, Yi-Zhou Huang, Hong-Wei Gao, Yan-Lin Jiang, Jun-Gen Hu, Jin-Kui Pi, An-Jing Chen, Yi Zhang, Li Zhou and Hui-Qi Xie

    Citation: Stem Cell Research & Therapy 2020 11:150

    Content type: Research

    Published on:

  46. Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured in vitro exhibit functional heterogeneit...

    Authors: Changbin Sun, Lei Wang, Hailun Wang, Tingrun Huang, Wenwen Yao, Jing Li and Xi Zhang

    Citation: Stem Cell Research & Therapy 2020 11:149

    Content type: Research

    Published on:

  47. Adipose-derived stem cell (ADSC) transplantation is a promising strategy to promote wound healing because of the paracrine function of stem cells. However, glucose-associated effects on stem cell paracrine fun...

    Authors: Jin Xu, Xiaoyu Liu, Feng Zhao, Ying Zhang and Zhe Wang

    Citation: Stem Cell Research & Therapy 2020 11:148

    Content type: Research

    Published on:

  48. Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-...

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2020 11:147

    Content type: Research

    Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:242

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