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  1. Mesenchymal stromal cells (MSCs) demonstrate considerable promise for acute respiratory distress syndrome (ARDS) and sepsis. However, standard approaches to MSC isolation generate highly heterogeneous cell pop...

    Authors: Shahd Horie, Claire Masterson, Jack Brady, Paul Loftus, Emma Horan, Lisa O’Flynn, Steve Elliman, Frank Barry, Timothy O’Brien, John G. Laffey and Daniel O’Toole
    Citation: Stem Cell Research & Therapy 2020 11:116
  2. Microvesicles (MVs) derived from human Wharton’s jelly mesenchymal stem cells (MSC-MVs) were demonstrated to ameliorate acute lung injury (ALI). We have previously found that MSC-MV-transferred hepatocyte grow...

    Authors: Wen-xia Chen, Jun Zhou, Sha-sha Zhou, Yu-dan Zhang, Tong-yu Ji, Xiao-li Zhang, Shu-min Wang, Tao Du and De-gang Ding
    Citation: Stem Cell Research & Therapy 2020 11:113
  3. Although dental pulp stem cells (DPSCs) isolated from periodontally compromised teeth (P-DPSCs) have been demonstrated to retain pluripotency and regenerative potential, their use as therapeutics remains large...

    Authors: Huan Zhou, Xuan Li, Yuan Yin, Xiao-Tao He, Ying An, Bei-Min Tian, Yong-Long Hong, Li-An Wu and Fa-Ming Chen
    Citation: Stem Cell Research & Therapy 2020 11:110

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:509

  4. Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public health problem. Osteogenic differentiation is a complex process associated with the differentiation of different cells...

    Authors: Liyuan Yu, Kai Xia, Xiao Cen, Xinqi Huang, Wentian Sun, Zhihe Zhao and Jun Liu
    Citation: Stem Cell Research & Therapy 2020 11:109
  5. Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly dim...

    Authors: Lucia Beltran-Camacho, Margarita Jimenez-Palomares, Marta Rojas-Torres, Ismael Sanchez-Gomar, Antonio Rosal-Vela, Sara Eslava-Alcon, Mª Carmen Perez-Segura, Ana Serrano, Borja Antequera-González, Jose Angel Alonso-Piñero, Almudena González-Rovira, Mª Jesús Extremera-García, Manuel Rodriguez-Piñero, Rafael Moreno-Luna, Martin Røssel Larsen and Mª Carmen Durán-Ruiz
    Citation: Stem Cell Research & Therapy 2020 11:106
  6. The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem ce...

    Authors: Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke and Wolfgang Wagner
    Citation: Stem Cell Research & Therapy 2020 11:105
  7. Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been perfor...

    Authors: Ani Sun, Wenni Gao and Ting Xiao
    Citation: Stem Cell Research & Therapy 2020 11:104
  8. In mammals, specification of primordial germ cells (PGCs) is established in the early post­implantation embryo. The bone morphogenetic protein (BMP)-SMAD and WNT3-β-catenin signaling initiate the gene regulato...

    Authors: Fang Fang, Zili Li, Qian Zhao, Chengliang Xiong and Ke Ni
    Citation: Stem Cell Research & Therapy 2020 11:100
  9. Equine amniotic mesenchymal stromal cells (AMSCs) and their conditioned medium (CM) were evaluated for their ability to inhibit in vitro proliferation of peripheral blood mononuclear cells (PBMCs) with and withou...

    Authors: Anna Lange-Consiglio, Pietro Romele, Marta Magatti, Antonietta Silini, Antonella Idda, Nicola Antonio Martino, Fausto Cremonesi and Ornella Parolini
    Citation: Stem Cell Research & Therapy 2020 11:99
  10. Retinitis pigmentosa (RP) is an inherited retinal disease characterized by progressive loss of photoreceptor cells. This study aim at exploring the effect of retinal pigment epithelium (RPE) derived from human...

    Authors: Deliang Zhu, Mengyuan Xie, Fabian Gademann, Jixing Cao, Peiyuan Wang, Yonglong Guo, Lan Zhang, Ting Su, Jun Zhang and Jiansu Chen
    Citation: Stem Cell Research & Therapy 2020 11:98

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:488

  11. Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim of this study was to investigate the effect of exosomes derived from mesenchymal stem cells (MSCs) on beta cells under...

    Authors: Jin Chen, Junqiu Chen, Yuanhang Cheng, Yunfeng Fu, Hongzhou Zhao, Minying Tang, Hu Zhao, Na Lin, Xiaohua Shi, Yan Lei, Shuiliang Wang, Lianghu Huang, Weizhen Wu and Jianming Tan
    Citation: Stem Cell Research & Therapy 2020 11:97
  12. Organoids are three-dimensional in vitro-grown cell clusters that recapitulate key features of native organs. In regenerative medicine, organoid technology represents a promising approach for the replacement o...

    Authors: Marta Dossena, Roberta Piras, Alessandro Cherubini, Mario Barilani, Erica Dugnani, Francesca Salanitro, Till Moreth, Francesco Pampaloni, Lorenzo Piemonti and Lorenza Lazzari
    Citation: Stem Cell Research & Therapy 2020 11:94
  13. The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the fields of developmental and stem cell biology. We are currently establishing the foundations for translation...

    Authors: Joaquim Vives and Laura Batlle-Morera
    Citation: Stem Cell Research & Therapy 2020 11:72
  14. Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of unknown etiology, but is closely associated with damage to dopaminergic neurons. MSA progression is rapid. Hence, long-term drug treatm...

    Authors: Kyung-Ran Park, Chul Ju Hwang, Hyung-Mun Yun, In Jun Yeo, Dong-Young Choi, Pil-Hoon Park, Hyung Sook Kim, Jung Tae Lee, Young Suk Jung, Sang-Bae Han and Jin Tae Hong
    Citation: Stem Cell Research & Therapy 2020 11:63
  15. The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development ev...

    Authors: Xiaowei Zhu, Suling Ding, Hui Li, Zhiwei Zhang, Lili Xu, Jian Wu, Xiangfei Wang, Yunzeng Zou, Xiangdong Yang and Junbo Ge
    Citation: Stem Cell Research & Therapy 2020 11:27
  16. To determine the impact of donor age on the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSCs) in treating adverse remodeling as the result of right ventricle (RV) pressure overload.

    Authors: Rong Liufu, Guocheng Shi, Xiaomin He, Jingjing Lv, Wei Liu, Fang Zhu, Chen Wen, Zhongqun Zhu and Huiwen Chen
    Citation: Stem Cell Research & Therapy 2020 11:96
  17. Chondrogenic progenitor cells (CPCs) have high self-renewal capacity and chondrogenic potential. Intra-articular delivery of purified mesenchymal stem cells (MSCs) from MRL/MpJ “superhealer” mice increased bon...

    Authors: Rikang Wang, Wei Jiang, Lang Zhang, Saisai Xie, Shuai Zhang, Shun Yuan, Yi Jin and Guangqian Zhou
    Citation: Stem Cell Research & Therapy 2020 11:93
  18. As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status ...

    Authors: Yun Xie, Bin Fang, Wenhui Liu, Guangshuai Li, Ru-Lin Huang, Lu Zhang, Jiahao He, Shuangbai Zhou, Kai Liu and Qingfeng Li
    Citation: Stem Cell Research & Therapy 2020 11:92
  19. Mesenchymal stem cells (MSCs) exert immunomodulatory functions by inducing the development and differentiation of naive T cells into T cells with an anti-inflammatory regulatory T cell (Treg) phenotype. Our pr...

    Authors: Qi-Hong Chen, Fei Wu, Lei Liu, Han-bing Chen, Rui-Qiang Zheng, Hua-Ling Wang and Li-Na Yu
    Citation: Stem Cell Research & Therapy 2020 11:91
  20. Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a dose-independent manner. APAP overdose...

    Authors: Chenxia Hu, Lingfei Zhao, Zhongwen Wu and Lanjuan Li
    Citation: Stem Cell Research & Therapy 2020 11:88
  21. Mesenchymal stem cells (MSCs) are pluripotent mesenchymal cells present in various adult tissues. MSCs secrete exosomes as regulators of the tumor niche, with involvement in tumorigenesis and metastasis. The r...

    Authors: Yuan Liang, Dalin Zhang, Linlin Li, Tian Xin, Yuwei Zhao, Rui Ma and Jiang Du
    Citation: Stem Cell Research & Therapy 2020 11:87
  22. Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally...

    Authors: Yi Sui, Wei Zhang, Tao Tang, Lili Gao, Ting Cao, Hongbo Zhu, Qinghua You, Bo Yu and Tao Yang
    Citation: Stem Cell Research & Therapy 2020 11:86
  23. Embryonic Sertoli cells (eSCs) have been known for playing important roles in male reproductive development system. In current studies, eSCs were mainly generated from induced intermediate mesoderm. The derivi...

    Authors: Chenze Xu, Yichen Dai, Ali Mohsin, Haifeng Hang, Yingping Zhuang and Meijin Guo
    Citation: Stem Cell Research & Therapy 2020 11:85
  24. The cancer stem cell hypothesis is an old idea which has been revived in recent years for many cancers, including gliomas. However, this concept has become controversial due to a series of studies with conflic...

    Authors: Lei Zhang, Hongwei Yu, Yuhui Yuan, John S. Yu, Zhenkun Lou, Yixue Xue and Yunhui Liu
    Citation: Stem Cell Research & Therapy 2020 11:84
  25. Autologous peripheral blood stem cell (auto-PBSC) transplantation is an effective therapeutic for the osteonecrosis of the femoral head (ONFH) but without prognosis estimation. This study mainly aimed to (1) d...

    Authors: Jiafei Pan, Quanwei Ding, Shuaijie Lv, Bingjiang Xia, Hongting Jin, Di Chen, Luwei Xiao and Peijian Tong
    Citation: Stem Cell Research & Therapy 2020 11:83
  26. Many studies have elegantly shown that murine and rat bone marrow-derived mesenchymal stromal cells (bmMSCs) contribute to muscle regeneration and improve muscle function. Yet, the ability of transplanted huma...

    Authors: Dominik Barisic, Marita Erb, Marie Follo, Dahlia Al-Mudaris, Bernd Rolauffs and Melanie L. Hart
    Citation: Stem Cell Research & Therapy 2020 11:79
  27. Keloid formation occurs in Caucasian, African, and Asian populations and is a severe psychosocial burden on patients. There is no permanent treatment for this problem as its pathogenesis is not properly unders...

    Authors: Subramanian Arjunan, Shu Uin Gan, Mahesh Choolani, Vaishnevi Raj, Jane Lim, Arijit Biswas, Ariff Bongso and Chui Yee Fong
    Citation: Stem Cell Research & Therapy 2020 11:78
  28. Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a s...

    Authors: Yaqian Hu, Lei Chen, Yi Gao, Pengzhen Cheng, Liu Yang, Chengtie Wu and Qiang Jie
    Citation: Stem Cell Research & Therapy 2020 11:77
  29. The unmet medical needs in repairing large muscle defects promote the development of tissue regeneration strategy. The use of bioactive molecules in combination with biomaterial scaffold has become an area of ...

    Authors: Yuanqiang Dong, Yuan Li, Chuan Zhang, Haibin Chen, Lijia Liu and Simeng Chen
    Citation: Stem Cell Research & Therapy 2020 11:76
  30. Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have shed great light on cardiac regenerative medicine and specifically myocardial repair in heart failure patients. However, the treatment...

    Authors: Xumin Guan, Wanzi Xu, He Zhang, Qian Wang, Jiuyang Yu, Ruyi Zhang, Yamin Chen, Yunlong Xia, Jiaxian Wang and Dongjin Wang
    Citation: Stem Cell Research & Therapy 2020 11:73

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:201

  31. Generation of red blood cells (RBCs) from hematopoietic stem cells (HSCs) in vitro takes about 21 days, making it unaffordable for clinical applications. Acceleration of the in vitro erythropoiesis process by ...

    Authors: Rutuja Kuhikar, Nikhat Khan, Joseph Philip, Sameer Melinkeri, Vaijayanti Kale and Lalita Limaye
    Citation: Stem Cell Research & Therapy 2020 11:71
  32. Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy in animal models of stroke using a dose of 100 μg. However, wheth...

    Authors: Laura Otero-Ortega, Fernando Laso-García, Mari Carmen Gómez-de Frutos, Luke Diekhorst, Arturo Martínez-Arroyo, Elisa Alonso-López, María Laura García-Bermejo, Macarena Rodríguez-Serrano, Mercedes Arrúe-Gonzalo, Exuperio Díez-Tejedor, Blanca Fuentes and María Gutiérrez-Fernández
    Citation: Stem Cell Research & Therapy 2020 11:70
  33. Transplantation of skeletal myoblast sheets is a promising strategy for the treatment of heart failure, and its therapeutic effects have already been proven in both animal disease models and clinical trials. M...

    Authors: Hiroko Iseoka, Shigeru Miyagawa, Atsuhiro Saito, Akima Harada and Yoshiki Sawa
    Citation: Stem Cell Research & Therapy 2020 11:69
  34. Angiogenesis plays an important role in tissue repair and regeneration, and conditioned medium (CM) derived from mesenchymal stem cells (MSC-CM) possesses pro-angiogenesis. Nevertheless, the profile and concen...

    Authors: Shanshan Jin, Chengzhe Yang, Jiahui Huang, Lianlian Liu, Yu Zhang, Shutong Li, Liguo Zhang, Qinfeng Sun and Pishan Yang
    Citation: Stem Cell Research & Therapy 2020 11:68
  35. NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a con...

    Authors: Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen and Jianyong Han
    Citation: Stem Cell Research & Therapy 2020 11:67
  36. Articular cartilage shows little or no capacity for intrinsic repair, generating a critical need of regenerative therapies for joint injuries and diseases such as osteoarthritis. Human-induced pluripotent stem...

    Authors: Amanda Dicks, Chia-Lung Wu, Nancy Steward, Shaunak S. Adkar, Charles A. Gersbach and Farshid Guilak
    Citation: Stem Cell Research & Therapy 2020 11:66
  37. Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains ver...

    Authors: Pengxiang Qu, Yongsheng Wang, Chengsheng Zhang and Enqi Liu
    Citation: Stem Cell Research & Therapy 2020 11:65
  38. Graft-versus-host disease (GvHD) is the main life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Thirty to 80% of GvHD patients do not respond to first-line treatment an...

    Authors: Cynthia Morata-Tarifa, María del Mar Macías-Sánchez, Antonio Gutiérrez-Pizarraya and Rosario Sanchez-Pernaute
    Citation: Stem Cell Research & Therapy 2020 11:64
  39. The process of bone repair is heavily dependent on the ability of human bone marrow mesenchymal stem cells (hMSCs) to undergo osteogenic differentiation. MicroRNAs have been shown to regulate this osteogenic p...

    Authors: Tao Wang, Chao Zhang, Cihu Wu, Jianyun Liu, Hui Yu, Xiaoou Zhou, Jie Zhang, Xinping Wang, Shan He, Xiaoyuan Xu, Baicheng Ma, Xiangxin Che and Weidong Li
    Citation: Stem Cell Research & Therapy 2020 11:62
  40. The homeostasis of oral pathogenic bacteria and probiotics plays a crucial role in maintaining the well-being and healthy status of human host. Our previous study confirmed that imbalanced oral microbiota coul...

    Authors: Nannan Han, Lu Jia, Lijia Guo, Yingying Su, Zhenhua Luo, Juan Du, Shenghui Mei and Yi Liu
    Citation: Stem Cell Research & Therapy 2020 11:61
  41. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD results from chronic inflammation of the lungs. Current treatments, including physical and chemical therapies, p...

    Authors: Phuong Le Thi Bich, Ha Nguyen Thi, Hoang Dang Ngo Chau, Tien Phan Van, Quyet Do, Hung Dong Khac, Dong Le Van, Luc Nguyen Huy, Khan Mai Cong, Thang Ta Ba, Trung Do Minh, Ngoc Vu Bich, Nhat Truong Chau and Phuc Van Pham
    Citation: Stem Cell Research & Therapy 2020 11:60

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:340

  42. Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate contribution to leukemia pathogenesis. However,...

    Authors: Jiali Huo, Leisheng Zhang, Xiang Ren, Chengwen Li, Xingxin Li, Peiyuan Dong, Xuan Zheng, Jinbo Huang, Yingqi Shao, Meili Ge, Jing Zhang, Min Wang, Neng Nie, Peng Jin and Yizhou Zheng
    Citation: Stem Cell Research & Therapy 2020 11:59
  43. Skeletal unloading can induce severe disuse osteopenia that often occurs in spaceflight astronauts or in patients subjected to prolonged bed-rest or immobility. Previously, we revealed a mechano-sensitive fact...

    Authors: Zebing Hu, Lijun Zhang, Han Wang, Yixuan Wang, Yingjun Tan, Lei Dang, Ke Wang, Zhongyang Sun, Gaozhi Li, Xinsheng Cao, Shu Zhang, Fei Shi and Ge Zhang
    Citation: Stem Cell Research & Therapy 2020 11:58
  44. The mechanisms by which macrophage phenotype contributes to mesenchymal stem cells (MSC)-mediated bone repair remain unclear. In this work, we investigated the influence of factors released by human macrophage...

    Authors: Gema Vallés, Fátima Bensiamar, Leila Maestro-Paramio, Eduardo García-Rey, Nuria Vilaboa and Laura Saldaña
    Citation: Stem Cell Research & Therapy 2020 11:57
  45. Wound healing is a complex pathophysiological process that involves a variety of cells and cytokines. In this study, we found that local injection of human amnion mesenchymal stem cells into wounds in rats cou...

    Authors: Shaoying Gao, Tao Chen, Yi Hao, Feifei Zhang, Xiujun Tang, Dali Wang, Zairong Wei and Jianping Qi
    Citation: Stem Cell Research & Therapy 2020 11:56
  46. In a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics. Trophobla...

    Authors: Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S. Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala, Yick W. Fong, Sitaram M. Emani, Ivan O. Rosas, Mark A. Perrella and Xiaoli Liu
    Citation: Stem Cell Research & Therapy 2020 11:55
  47. The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect ...

    Authors: Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales and Xavier Navarro
    Citation: Stem Cell Research & Therapy 2020 11:53
  48. Mesenchymal stem cell (MSC) transplantation is a fast-developing therapy in regenerative medicine. However, some concerns have been raised regarding their safety and the infusion-related pro-coagulant activity...

    Authors: Louise C. F. Coppin, Françoise Smets, Jérome Ambroise, Etienne E. M. Sokal and Xavier Stéphenne
    Citation: Stem Cell Research & Therapy 2020 11:51

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