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  1. Spinal cord injury (SCI) is a complex and severe neurological condition. Mesenchymal stem cells (MSCs) and their secreted factors show promising potential for regenerative medicine. Many studies have investiga...

    Authors: Ya-Tzu Chen, May-Jywan Tsai, Nini Hsieh, Ming-Jei Lo, Meng-Jen Lee, Henrich Cheng and Wen-Cheng Huang
    Citation: Stem Cell Research & Therapy 2019 10:390
    Content type: Research Published on:

  2. Neural tube defects (NTDs) are the most serious and common birth defects in the clinic. The SRY-related HMG box B1 (SoxB1) gene family has been implicated in different processes of early embryogenesis. Sox19b ...

    Authors: Xian Li, Wenjuan Zhou, Xinyue Li, Ming Gao, Shufang Ji, Wenyu Tian, Guangyu Ji, Jingyi Du and Aijun Hao
    Citation: Stem Cell Research & Therapy 2019 10:389
    Content type: Research Published on:

  3. Animal cell-based systems have been critical tools in understanding tissue development and physiology, but they are less successful in more practical tasks, such as predicting human toxicity to pharmacological...

    Authors: Alessandro Pirosa, Karen L. Clark, Jian Tan, Shuting Yu, Yuanheng Yang, Rocky S. Tuan and Peter G. Alexander
    Citation: Stem Cell Research & Therapy 2019 10:388
    Content type: Research Published on:

  6. Radiation dermatitis is a refractory skin injury caused by radiotherapy. Human fetal skin-derived stem cell (hFSSC) is a preferable source for cell therapy and skin tissue regeneration. In the present study, w...

    Authors: Xiaoli Rong, Jiannan Li, Yanyan Yang, Liyan Shi and Tiechao Jiang
    Citation: Stem Cell Research & Therapy 2019 10:383
    Content type: Research Published on:

  7. Spermatogonial stem cell (SSC) transplantation technology as a promising option for male fertility preservation has received increasing attention, along with efficient SSC purification technology as a necessar...

    Authors: Jia Tian, Ke Ma, Cheng-bin Pei, Shao-hua Zhang, Xue Li, Yue Zhou, Bei Yan, Hong-yan Wang and Liang-hong Ma
    Citation: Stem Cell Research & Therapy 2019 10:382
    Content type: Research Published on:

  8. Mesenchymal stem cells (MSCs) play a significant role in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication by delivering microRNAs (miRNAs). This study aimed to ...

    Authors: Haiyang Xu, Guifang Zhao, Yu Zhang, Hong Jiang, Weiyao Wang, Donghai Zhao, Jin Hong, Hongquan Yu and Ling Qi
    Citation: Stem Cell Research & Therapy 2019 10:381
    Content type: Research Published on:

  9. Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ...

    Authors: Masoumeh Zarei-Kheirabadi, Mahdi Hesaraki, Sahar Kiani and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2019 10:380
    Content type: Research Published on:

  10. Restoration of massive bone defects remains a huge challenge for orthopedic surgeons. Insufficient vascularization and slow bone regeneration limited the application of tissue engineering in bone defect. The e...

    Authors: Jingyuan Chen, Chang Tu, Xiangyu Tang, Hao Li, Jiyuan Yan, Yongzhuang Ma, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2019 10:379
    Content type: Research Published on:

  11. Magnesium (Mg2+)-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells (DPSCs), but the regulatory mechanisms remain undefined. The aim of this work was to assess magnesiu...

    Authors: Yuanyuan Kong, Xiaoli Hu, Yingqun Zhong, Ke Xu, Buling Wu and Jianmao Zheng
    Citation: Stem Cell Research & Therapy 2019 10:378
    Content type: Research Published on:

  12. Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological processes such as prolifera...

    Authors: Lizhi Han, Bo Wang, Ruoyu Wang, Song Gong, Guo Chen and Weihua Xu
    Citation: Stem Cell Research & Therapy 2019 10:377
    Content type: Review Published on:

  13. The umbilical cord blood (UCB) has been widely accepted as an alternative source of hematopoietic stem/progenitor cells (HSPCs) for transplantation, and its use in adults is still restricted because of low abs...

    Authors: Qiuyang Li, Dewan Zhao, Qiang Chen, Maowen Luo, Jingcao Huang, Cao Yang, Fangfang Wang, Wenxian Li and Ting Liu
    Citation: Stem Cell Research & Therapy 2019 10:376
    Content type: Research Published on:

  14. Aspirin has been demonstrated to promote osteoblast-mediated bone formation and inhibit osteoclast (OC)-mediated bone resorption. However, it remains unclear whether aspirin influences other immune cells durin...

    Authors: Lili Wu, Zhenhua Luo, Yitong Liu, Lu Jia, Yiyang Jiang, Juan Du, Lijia Guo, Yuxing Bai and Yi Liu
    Citation: Stem Cell Research & Therapy 2019 10:375
    Content type: Research Published on:

  15. Limbal stem cells (LSC) sustain the corneal integrity and homeostasis. LSC deficiency (LSCD) leads to loss of corneal transparency and blindness. A clinical approach to treat unilateral LSCD comprises autologo...

    Authors: Nuria Nieto-Nicolau, Eva M. Martínez-Conesa, Alba M. Velasco-García, Caterina Aloy-Reverté, Anna Vilarrodona and Ricardo P. Casaroli-Marano
    Citation: Stem Cell Research & Therapy 2019 10:374
    Content type: Research Published on:

  16. Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap betwee...

    Authors: Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa and Irene C. Turnbull
    Citation: Stem Cell Research & Therapy 2019 10:373
    Content type: Research Published on:

  17. Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) via paracrine hepatocyte growth factor (HGF) and to induce the differentiation of dendritic cells (DCs) into tolerogenic dendr...

    Authors: Zhonghua Lu, Wei Chang, Shanshan Meng, Xiuping Xu, Jianfeng Xie, Fengmei Guo, Yi Yang, Haibo Qiu and Ling Liu
    Citation: Stem Cell Research & Therapy 2019 10:372
    Content type: Research Published on:

  18. Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit...

    Authors: Karl-Henrik Grinnemo, Marie Löfling, Lubov Nathanson, Roland Baumgartner, Daniel F. J. Ketelhuth, Vladimir Beljanski, Lindsay C. Davies and Cecilia Österholm
    Citation: Stem Cell Research & Therapy 2019 10:371
    Content type: Research Published on:

  19. We have recently demonstrated that amniotic fluid stem cells (AFSC) express renal progenitor markers and can be differentiated in vitro into renal lineage cell types, viz, juxtaglomerular and renal proximal tu...

    Authors: Ekta Minocha, Rohit Anthony Sinha, Manali Jain, Chandra Prakash Chaturvedi and Soniya Nityanand
    Citation: Stem Cell Research & Therapy 2019 10:370
    Content type: Research Published on:

  20. Cartilage tissue engineering is a promising technique for repairing cartilage defect. Due to the limitation of cell number and proliferation, mesenchymal stem cells (MSCs) have been developed as a substitute t...

    Authors: Imam Rosadi, Karina Karina, Iis Rosliana, Siti Sobariah, Irsyah Afini, Tias Widyastuti and Anggraini Barlian
    Citation: Stem Cell Research & Therapy 2019 10:369
    Content type: Research Published on:

  21. Gingiva-derived mesenchymal stem cells (GMSCs) obtained multipotent differentiation and immunomodulatory properties. However, collecting healthy gingival tissues may be challenging in the clinical situation. T...

    Authors: Tingting Yu, Boxi Yan, Jing Li, Ting Zhang, Ruili Yang, Xuedong Wang, Yan Liu and Dawei Liu
    Citation: Stem Cell Research & Therapy 2019 10:368
    Content type: Research Published on:

  22. Anal sphincter injury leads to fecal incontinence. Based on the regenerative capability of laser and human adipose-derived stem cells (hADSCs), this study was designed to assess the effects of co-application o...

    Authors: Arash Sarveazad, Asrin Babahajian, Abazar Yari, Chris K. Rayner, Marjan Mokhtare, Arash Babaei-Ghazani, Shahram Agah, Bahar Mahjoubi, Jebreil Shamseddin and Mahmoud Yousefifard
    Citation: Stem Cell Research & Therapy 2019 10:367
    Content type: Research Published on:

  23. The airways of mammalian lung are lined with highly specialized cell types that are the target of airborne toxicants and injury. Several epithelial cell types and bone marrow-derived mesenchymal stem cells hav...

    Authors: Suyun Fang, Suhong Zhang, Haiting Dai, Xiaoxiang Hu, Changgong Li and Yiming Xing
    Citation: Stem Cell Research & Therapy 2019 10:366
    Content type: Research Published on:

  24. Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically...

    Authors: Cheng Cheng, Yunfeng Wang, Luo Guo, Xiaoling Lu, Weijie Zhu, Waqas Muhammad, Liyan Zhang, Ling Lu, Junyan Gao, Mingliang Tang, Fangyi Chen, Xia Gao, Huawei Li and Renjie Chai
    Citation: Stem Cell Research & Therapy 2019 10:365
    Content type: Research Published on:

  25. The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatobl...

    Authors: Tingcai Pan, Yan Chen, Yuanqi Zhuang, Fan Yang, Yingying Xu, Jiawang Tao, Kai You, Ning Wang, Yuhang Wu, Xianhua Lin, Feima Wu, Yanli Liu, Yingrui Li, Guodong Wang and Yin-xiong Li
    Citation: Stem Cell Research & Therapy 2019 10:364
    Content type: Research Published on:

  26. Diabetic nephropathy (DN) is one of the most severe chronic diabetic complications and the main cause of end-stage renal disease. Chronic inflammation plays a key role in the development of DN. However, few tr...

    Authors: Xingxing An, Guangneng Liao, Younan Chen, Ai Luo, Jingping Liu, Yujia Yuan, Lan Li, Lichuan Yang, Hong Wang, Fang Liu, Guang Yang, Shounan Yi, Yuanmin Li, Jingqiu Cheng and Yanrong Lu
    Citation: Stem Cell Research & Therapy 2019 10:363
    Content type: Research Published on:

  27. With the development of regenerative medicine and tissue engineering technology, almost all stem cell therapy is efficacious for the treatment of premature ovarian failure (POF) or premature ovarian insufficie...

    Authors: Boxian Huang, Chunfeng Qian, Chenyue Ding, Qingxia Meng, Qinyan Zou and Hong Li
    Citation: Stem Cell Research & Therapy 2019 10:362
    Content type: Research Published on:

  28. The composition and function of the adipose tissue covering the heart are poorly known. In this study, we have investigated the epicardial adipose tissue (EAT) covering the cardiac ventricular muscle and the E...

    Authors: Carmen Lambert, Gemma Arderiu, Maria Teresa Bejar, Javier Crespo, Maribel Baldellou, Oriol Juan-Babot and Lina Badimon
    Citation: Stem Cell Research & Therapy 2019 10:361
    Content type: Research Published on:

  30. Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulator...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Jiangmei Wang, Ruoqiong Huang, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2019 10:359
    Content type: Review Published on:

  31. The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to the secreted paracrine factors, which comprise exosomes. Exosomes are small, saucer-shaped vesicles containing miRNAs, mRN...

    Authors: Kun Yang, Dong Li, Meitian Wang, Zhiliang Xu, Xiao Chen, Qiao Liu, Wenjie Sun, Jiangxia Li, Yaoqin Gong, Duo Liu, Changshun Shao, Qiji Liu and Xi Li
    Citation: Stem Cell Research & Therapy 2019 10:358
    Content type: Research Published on:

  32. The degenerative disc disease (DDD) is a major cause of low back pain. The physiological low-glucose microenvironment of the cartilage endplate (CEP) is disrupted in DDD. Glucose influences protein O-GlcNAcylatio...

    Authors: Chao Sun, Weiren Lan, Bin Li, Rui Zuo, Hui Xing, Minghan Liu, Jie Li, Yuan Yao, Junlong Wu, Yu Tang, Huan Liu and Yue Zhou
    Citation: Stem Cell Research & Therapy 2019 10:357
    Content type: Research Published on:

  33. Orthopaedic diseases are one of the major targets for regenerative medicine. In this context, Wharton’s jelly (WJ) is an alternative source to bone marrow (BM) for allogeneic transplantation since its isolatio...

    Authors: Raquel Cabrera-Pérez, Marta Monguió-Tortajada, Ana Gámez-Valero, Raquel Rojas-Márquez, Francesc Enric Borràs, Santiago Roura and Joaquim Vives
    Citation: Stem Cell Research & Therapy 2019 10:356
    Content type: Research Published on:

  34. White adipose tissue includes subcutaneous and visceral adipose tissue (SAT and VAT) with different metabolic features. SAT protects from metabolic disorders, while VAT promotes them. The proliferative and adi...

    Authors: Zhenzhen Pan, Zixin Zhou, Huiying Zhang, Hui Zhao, Peixuan Song, Di Wang, Jilong Yin, Wanyi Zhao, Zhaoxiang Xie, Fuwu Wang, Yan Li, Chun Guo, Faliang Zhu, Lining Zhang and Qun Wang
    Citation: Stem Cell Research & Therapy 2019 10:355
    Content type: Research Published on:

  35. Mesenchymal stem cells are heterogenous populations with hematopoietic supporting and immunomodulating capacities. Enormous studies have focused on their preclinical or clinical therapeutic effects, yet the sy...

    Authors: Qinjun Zhao, Leisheng Zhang, Yimeng Wei, Hao Yu, Linglin Zou, Jiali Huo, Hongju Yang, Baoquan Song, Teng Wei, Dan Wu, Wenxia Zhang, Lei Zhang, Dengke Liu, Zongjin Li, Ying Chi, Zhibo Han…
    Citation: Stem Cell Research & Therapy 2019 10:354
    Content type: Research Published on:

  36. In most stem cell therapy strategies reported to date, stem cells are introduced to damaged tissue sites to repair and regenerate the original tissue structure and function. MSC therapeutic efficacies are inco...

    Authors: Mitsuyoshi Nakao, Kyungsook Kim, Kenichi Nagase, David W. Grainger, Hideko Kanazawa and Teruo Okano
    Citation: Stem Cell Research & Therapy 2019 10:353
    Content type: Research Published on:

  37. Traumatic brain injury (TBI) is a common neurotrauma leading to brain dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI. However, their ...

    Authors: Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang…
    Citation: Stem Cell Research & Therapy 2019 10:352
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:522

  38. Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucid...

    Authors: Zheng Li, Shuhao Liu, Tengfei Fu, Yi Peng and Jian Zhang
    Citation: Stem Cell Research & Therapy 2019 10:351
    Content type: Research Published on:

  39. Human adipose-derived stem cells (hASCs) are a subset of mesenchymal stem cells (MSCs); it has been regarded as one of the most promising stem cells. We previously found that fibroblast growth factor-2 (FGF-2)...

    Authors: Yuanyuan Ma, Natsuko Kakudo, Naoki Morimoto, Fangyuan Lai, Shigeru Taketani and Kenji Kusumoto
    Citation: Stem Cell Research & Therapy 2019 10:350
    Content type: Research Published on:

  40. Distinct mechanical stimuli are known to manipulate the behaviors of embryonic stem cells (ESCs). Fundamental rationale of how ESCs respond to mechanical forces and the potential biological effects remain elus...

    Authors: Jiawen Wang, Yi Wu, Xiao Zhang, Fan Zhang, Dongyuan Lü, Bing Shangguan, Yuxin Gao and Mian Long
    Citation: Stem Cell Research & Therapy 2019 10:349
    Content type: Research Published on:

  41. Bone marrow mesenchymal stem cells (BMSCs) can partially repair chemotherapy-induced ovarian damage. However, low survival rate after transplantation hampers the therapeutic efficiency of BMSCs. Heat shock pre...

    Authors: Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie, Chuhai Xie and Xiafei Fu
    Citation: Stem Cell Research & Therapy 2019 10:348
    Content type: Research Published on:

  42. Extracellular vesicles (EVs) are cellular-derived versatile transporters with a specialized property for trafficking a variety of cargo, including metabolites, growth factors, cytokines, proteins, lipids, and ...

    Authors: Mujib Ullah, Yang Qiao, Waldo Concepcion and Avnesh S. Thakor
    Citation: Stem Cell Research & Therapy 2019 10:347
    Content type: Review Published on:

  43. Osteoarthritis and cartilage injury treatment is an unmet clinical need. Therefore, development of new approaches to treat these diseases is critically needed. Previous work in our laboratory has shown that mu...

    Authors: Xueqin Gao, Haizi Cheng, Hassan Awada, Ying Tang, Sarah Amra, Aiping Lu, Xuying Sun, Guijin Lv, Charles Huard, Bing Wang, Xiaohong Bi, Yadong Wang and Johnny Huard
    Citation: Stem Cell Research & Therapy 2019 10:346
    Content type: Research Published on:

  44. An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in sepsis. MSC-secreted ...

    Authors: Feng Liu, Haibo Qiu, Ming Xue, Shi Zhang, Xiwen Zhang, Jingyuan Xu, Jianxiao Chen, Yi Yang and Jianfeng Xie
    Citation: Stem Cell Research & Therapy 2019 10:345
    Content type: Research Published on:

  45. Satellite cells, a population of unipotent stem cells attached to muscle fibers, determine the excellent regenerative capability of injured skeletal muscles. Myogenic potential is also exhibited by other cell ...

    Authors: Paulina Kasprzycka, Karolina Archacka, Kamil Kowalski, Bartosz Mierzejewski, MaÅ‚gorzata Zimowska, Iwona Grabowska, Mariusz Piotrowski, Milena RafaÅ‚ko, Agata Ryżko, Aliksandra Irhashava, Kamil Senderowski, Magdalena GoÅ‚Ä…bek, WÅ‚adysÅ‚awa StremiÅ„ska, Katarzyna JaÅ„czyk-Ilach, Marta Koblowska, Roksana Iwanicka-Nowicka…
    Citation: Stem Cell Research & Therapy 2019 10:343
    Content type: Research Published on:

  46. Injury of stem cell niches may disturb tissue homeostasis and regeneration coordinated by specific niche components. Yet, the mechanisms of stem cell niche restoration remain poorly understood. Herein, we exam...

    Authors: Georgy Sagaradze, Nataliya Basalova, Vladimir Kirpatovsky, Dmitry Ohobotov, Peter Nimiritsky, Olga Grigorieva, Vladimir Popov, Armais Kamalov, Vsevolod Tkachuk and Anastasia Efimenko
    Citation: Stem Cell Research & Therapy 2019 10:342
    Content type: Research Published on:

  47. Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not exist naturally and are instead generated (“induc...

    Authors: Sharif Moradi, Hamid Mahdizadeh, Tomo Šarić, Johnny Kim, Javad Harati, Hosein Shahsavarani, Boris Greber and Joseph B. Moore IV
    Citation: Stem Cell Research & Therapy 2019 10:341
    Content type: Review Published on:

  48. The Wnt/β-catenin pathway is involved in the osteogenic differentiation of human adipose-derived stem cells (hASCs) under cyclic strain. Very little is known about the role of microRNAs in these events.

    Authors: Yadong Luo, Ran Ge, Heming Wu, Xu Ding, Haiyang Song, Huan Ji, Meng Li, Yunan Ma, Sheng Li, Chenxing Wang and Hongming Du
    Citation: Stem Cell Research & Therapy 2019 10:339
    Content type: Research Published on:

  49. The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This r...

    Authors: Marc G. Jeschke, Sarah Rehou, Matthew R. McCann and Shahriar Shahrokhi
    Citation: Stem Cell Research & Therapy 2019 10:337
    Content type: Short report Published on:
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