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  1. Stem cells play a therapeutic role mainly through immunoregulation. However, the immunomodulatory function of stem cells may be affected by inflammation-related factors in patients’ serum. Therefore, this stud...

    Authors: Yong-Hong Wang, Meng-Lan Wang, Ya-Chao Tao, Dong-Bo Wu, En-Qiang Chen and Hong Tang
    Citation: Stem Cell Research & Therapy 2023 14:231
  2. Native bone marrow (BM) mesenchymal stem/stromal cells (BM-MSCs) participate in generating and shaping the skeleton and BM throughout the lifespan. Moreover, BM-MSCs regulate hematopoiesis by contributing to t...

    Authors: Loïc Fiévet, Nicolas Espagnolle, Daniela Gerovska, David Bernard, Charlotte Syrykh, Camille Laurent, Pierre Layrolle, Julien De Lima, Arthur Justo, Nicolas Reina, Louis Casteilla, Marcos J. Araúzo-Bravo, Abderrahim Naji, Jean-Christophe Pagès and Frédéric Deschaseaux
    Citation: Stem Cell Research & Therapy 2023 14:229
  3. A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been c...

    Authors: Fitriana N. Rahmawati, Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Hirotaka Konishi, Weizhen Jia and Nobuyuki Takakura
    Citation: Stem Cell Research & Therapy 2023 14:227
  4. Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal, pluripotency, and immunomodulatory properties. The microenvironment i...

    Authors: Zhilong Huang, Yingying Huang, Xiner Ning, Haodi Li, Qiqi Li and Junjie Wu
    Citation: Stem Cell Research & Therapy 2023 14:222
  5. Chronic limb-threatening ischemia (CLTI) represents the final stage of peripheral arterial disease. Approximately one-third of patients with CLTI are not eligible for conventional surgical treatments. Furtherm...

    Authors: Martha L. Arango-Rodríguez, Ligia C. Mateus, Claudia L. Sossa, Silvia M. Becerra-Bayona, Víctor Alfonso Solarte-David, Miguel Enrique Ochoa Vera, Lady T. Giratá Viviescas, Ana M. Vera Berrio, Sergio Eduardo Serrano, Oliverio Vargas, Andrés Catalá Isla, Alape Benitez and Germán Rangel
    Citation: Stem Cell Research & Therapy 2023 14:221
  6. Xerostomia is a salivary gland dysfunction that negatively impacts the life quality of patients; however, there is no effective treatment for xerostomia. Bioengineered organs, generated using stem cells obtain...

    Authors: Bo kyoung Kang, Zhu Zhu, Jian Wang, Jia Zhou, Shun Yu, Xianyu Zhou, Zhenmin Zhao, Aiguo Xie, Lin Lu and Jun Yang
    Citation: Stem Cell Research & Therapy 2023 14:220
  7. Androgenetic alopecia (AGA) is one of the most common hair loss diseases worldwide. However, current treatments including medicine, surgery, and stem cells are limited for various reasons. Cell-free fat extrac...

    Authors: Yizuo Cai, Zhuoxuan Jia, Yichen Zhang, Bijun Kang, Chingyu Chen, Wei Liu, Wei Li and Wenjie Zhang
    Citation: Stem Cell Research & Therapy 2023 14:219
  8. Following an ischemic injury to the brain, the induction of angiogenesis is critical to neurological recovery. The angiogenic benefits of mesenchymal stem cells (MSCs) have been attributed at least in part to ...

    Authors: Jolene Phelps, David A. Hart, Alim P. Mitha, Neil A. Duncan and Arindom Sen
    Citation: Stem Cell Research & Therapy 2023 14:218
  9. Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung injury with high mortality; no approved medication exists. Efficacy and safety of bone marrow–derived, allogeneic, multipotent...

    Authors: Kazuya Ichikado, Toru Kotani, Yasuhiro Kondoh, Hideaki Imanaka, Takeshi Johkoh, Kiminori Fujimoto, Shin Nunomiya, Tomotaka Kawayama, Masanori Sawada, Eric Jenkins, Sadatomo Tasaka and Satoru Hashimoto
    Citation: Stem Cell Research & Therapy 2023 14:217
  10. Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for various diseases. These have certain notable functions such as homing to inflammation sites, tissue repair, and immune regulation. In...

    Authors: Yukiya Takayama, Kosuke Kusamori, Yuri Katsurada, Shu Obana, Shoko Itakura and Makiya Nishikawa
    Citation: Stem Cell Research & Therapy 2023 14:216
  11. Redox signaling and energy metabolism are known to be involved in controlling the balance between self-renewal and proliferation/differentiation of stem cells. In this study we investigated metabolic and redox...

    Authors: Francesca Agriesti, Francesca Landini, Mirko Tamma, Consiglia Pacelli, Carmela Mazzoccoli, Giovanni Calice, Vitalba Ruggieri, Giuseppe Capitanio, Giorgio Mori, Claudia Piccoli and Nazzareno Capitanio
    Citation: Stem Cell Research & Therapy 2023 14:215
  12. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain...

    Authors: Jing Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis-Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo and Guojun Bu
    Citation: Stem Cell Research & Therapy 2023 14:214
  13. Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long noncoding RNAs (lncRNAs) reportedly have essential roles...

    Authors: Hewei Xiong, Sen Ren, Jing Chen, Xiaofan Yang, Yutian Liu, Zhao Xu, Jiahe Guo, Tao Jiang, Meng Yuan, Yang Liu, Guolei Zhang, Wenqing Li, Hans-Günther Machens and Zhenbing Chen
    Citation: Stem Cell Research & Therapy 2023 14:213
  14. Retinitis pigmentosa (RP) is an inherited retinal disease that results in photoreceptor degeneration, leading to severe vision loss or blindness. Due to its genetic heterogeneity, developing a new gene therapy...

    Authors: Eric D. Jong, Sabiha Hacibekiroglu, Lily Guo, Evan Sawula, Biao Li, Chengjin Li, Margaret T. Ho, Molly S. Shoichet, Valerie A. Wallace and Andras Nagy
    Citation: Stem Cell Research & Therapy 2023 14:212
  15. The efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, these trials focu...

    Authors: Fengbiao Guo, Quanren Pan, Ting Chen, Shuzhen Liao, Shangmei Li, Aifen Li, Shuxian Chen, Jiaxuan Chen, Zengzhi Xiao, Hongyong Su, Lawei Yang, Chen Yang, Hua-feng Liu and Qingjun Pan
    Citation: Stem Cell Research & Therapy 2023 14:211
  16. Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce ...

    Authors: Lili Legiawati, Lis Surachmiati Suseno, Irma Bernadette S. Sitohang, Shannaz Nadia Yusharyahya, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Trie Kurniawati, Athaya Ardelia and Kanya Paramastri
    Citation: Stem Cell Research & Therapy 2023 14:210
  17. Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entitie...

    Authors: Ana S. Iltis, Grace Koster, Emily Reeves and Kirstin R. W. Matthews
    Citation: Stem Cell Research & Therapy 2023 14:209
  18. Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, der...

    Authors: Zhuokai Liang, Yufei He, Haojing Tang, Jian Li, Junrong Cai and Yunjun Liao
    Citation: Stem Cell Research & Therapy 2023 14:207
  19. Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response i...

    Authors: Michael V. Schrodt, Riley M. Behan-Bush, Jesse N. Liszewski, Madeleine E. Humpal-Pash, Lauren K. Boland, Sabrina M. Scroggins, Donna A. Santillan and James A. Ankrum
    Citation: Stem Cell Research & Therapy 2023 14:206
  20. Skeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of multinuclear skeletal muscle is stably maintained under steady condit...

    Authors: Takamitsu Tatsukawa, Kohei Kano, Kei-ichi Nakajima, Takashi Yazawa, Ryoji Eguchi, Maki Kabara, Kiwamu Horiuchi, Taiki Hayasaka, Risa Matsuo, Naoyuki Hasebe, Nobuyoshi Azuma and Jun-ichi Kawabe
    Citation: Stem Cell Research & Therapy 2023 14:205
  21. Skeletal muscle regeneration is a complex process regulated by many cytokines and growth factors. Among the important signaling pathways regulating the myogenic cell identity are these involving SDF-1 and NOTC...

    Authors: Bartosz Mierzejewski, Iwona Grabowska, Zuzanna Michalska, Kamila Zdunczyk, Franciszek Zareba, Aliksandra Irhashava, Marta Chrzaszcz, Magdalena Patrycy, Wladyslawa Streminska, Katarzyna Janczyk-Ilach, Marta Koblowska, Roksana Iwanicka-Nowicka, Agnieszka Gromadka, Kamil Kowalski, Maria Anna Ciemerych and Edyta Brzoska
    Citation: Stem Cell Research & Therapy 2023 14:204
  22. Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper ski...

    Authors: Zhihao Wang, Rob Knight, Phil Stephens, E. M. Ongkosuwito, Frank A. D. T. G. Wagener and Johannes W. Von den Hoff
    Citation: Stem Cell Research & Therapy 2023 14:203
  23. Mitochondrial dysfunction is involved in several diseases ranging from genetic mitochondrial disorders to chronic metabolic diseases. An emerging approach to potentially treat mitochondrial dysfunction is the ...

    Authors: David F. Bodenstein, Pavel Powlowski, Kassandra A. Zachos, Dana El Soufi El Sabbagh, Hyunjin Jeong, Liliana Attisano, Landon Edgar, Douglas C. Wallace and Ana Cristina Andreazza
    Citation: Stem Cell Research & Therapy 2023 14:202
  24. Human multilineage-differentiating stress enduring (Muse) cells are nontumorigenic endogenous pluripotent-like stem cells that can be easily obtained from various adult or fetal tissues. Regenerative effects o...

    Authors: Honorine Dushime, Stéphanie G. Moreno, Christine Linard, Annie Adrait, Yohann Couté, Juliette Peltzer, Sébastien Messiaen, Claire Torres, Lydia Bensemmane, Daniel Lewandowski, Paul-Henri Romeo, Vanessa Petit and Nathalie Gault
    Citation: Stem Cell Research & Therapy 2023 14:201
  25. Advanced renal cell carcinoma (RCC) is therapeutically challenging. RCC progression is facilitated by mesenchymal stem/stromal cells (MSCs) that exert remarkable tumor tropism. The specific mechanisms mediatin...

    Authors: Piotr Popławski, Weronika Zarychta-Wiśniewska, Anna Burdzińska, Joanna Bogusławska, Anna Adamiok-Ostrowska, Karolina Hanusek, Beata Rybicka, Alex Białas, Helena Kossowska, Roksana Iwanicka-Rokicka, Marta Koblowska, Leszek Pączek and Agnieszka Piekiełko-Witkowska
    Citation: Stem Cell Research & Therapy 2023 14:200
  26. Induced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell types of the body. This makes them highly promising for cellular therapy...

    Authors: Hassan R. W. Ali, Salwa Suliman, Tarig Al-Hadi Osman, Manuel Carrasco, Ove Bruland, Daniela-Elena Costea, Helge Ræder and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2023 14:199
  27. Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior repair strategies. Exos...

    Authors: Lin Zhong, Jingjing Wang, Peng Wang, Xiaoyin Liu, Peng Liu, Xu Cheng, Lujia Cao, Hongwei Wu, Jing Chen and Liangxue Zhou
    Citation: Stem Cell Research & Therapy 2023 14:198
  28. Mesenchymal stem cell (MSC) treatment plays a major role in the management of acute lung injury (ALI), and neutrophils are the initial line of defense against ALI. However, the effect of MSCs on neutrophils in...

    Authors: Bing Feng, Xudong Feng, Yingduo Yu, Haoying Xu, Qingqing Ye, Ruitian Hu, Xinru Fang, Feiqiong Gao, Jian Wu, Qiaoling Pan, Jiong Yu, Guanjing Lang, Lanjuan Li and Hongcui Cao
    Citation: Stem Cell Research & Therapy 2023 14:197
  29. High dosage of dexamethasone (Dex) is an effective treatment for multiple diseases; however, it is often associated with severe side effects including muscle atrophy, resulting in higher risk of falls and poor...

    Authors: Belle Yu-Hsuan Wang, Allen Wei-Ting Hsiao, Hoi Ting Shiu, Nicodemus Wong, Amanda Yu-Fan Wang, Chien-Wei Lee, Oscar Kuang-Sheng Lee and Wayne Yuk-Wai Lee
    Citation: Stem Cell Research & Therapy 2023 14:195
  30. Many problems related to disorders and defects of bone tissue caused by aging, diseases, and injuries have been solved by the multidisciplinary research field of regenerative medicine and tissue engineering. N...

    Authors: Hadi Sadeghzadeh, Hassan Dianat-Moghadam, Azizeh Rahmani Del Bakhshayesh, Daryush Mohammadnejad and Ahmad Mehdipour
    Citation: Stem Cell Research & Therapy 2023 14:194
  31. Peripheral artery disease is an ischemic vascular disease caused by the blockage of blood vessels supplying blood to the lower extremities. Mesenchymal stem cells (MSCs) and endothelial colony-forming cells (E...

    Authors: Young Cheol Song, Gyu Tae Park, Hye Ji Moon, Eun-Bae Choi, Mi-Ju Lim, Jung Won Yoon, Nayeon Lee, Sang Mo Kwon, Byung-Joo Lee and Jae Ho Kim
    Citation: Stem Cell Research & Therapy 2023 14:193
  32. Chronic diseases with comorbidities or associated risk factors may impair the function of regenerative cells and the regenerative microenvironment. Following this consideration, the vasculogenic conditioning c...

    Authors: Amankeldi A. Salybekov, Mehdi Hassanpour, Shuzo Kobayashi and Takayuki Asahara
    Citation: Stem Cell Research & Therapy 2023 14:191
  33. The circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This time-keeping machinery is required for orchestrating myogenic progenitor properti...

    Authors: Tali Kiperman, Weini Li, Xuekai Xiong, Hongzhi Li, David Horne and Ke Ma
    Citation: Stem Cell Research & Therapy 2023 14:190
  34. Huntington’s disease (HD) is a motor and cognitive neurodegenerative disorder due to prominent loss of striatal medium spiny neurons (MSNs). Cell replacement using human embryonic stem cells (hESCs) derivative...

    Authors: Roberta Schellino, Dario Besusso, Roberta Parolisi, Gabriela B. Gómez-González, Sveva Dallere, Linda Scaramuzza, Marta Ribodino, Ilaria Campus, Paola Conforti, Malin Parmar, Marina Boido, Elena Cattaneo and Annalisa Buffo
    Citation: Stem Cell Research & Therapy 2023 14:189
  35. Mesenchymal stem cells (MSCs) are widely used in a variety of tissue regeneration and clinical trials due to their multiple differentiation potency. However, it remains challenging to maintain their replicativ...

    Authors: Shifeng Ling, Tienan Chen, Shaojiao Wang, Wei Zhang, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Song Ning, Jiayin Liu, Lianju Qin, Haley O. Tucker, Niansong Wang and Xizhi Guo
    Citation: Stem Cell Research & Therapy 2023 14:188
  36. Mesenchymal stromal cells (MSCs) have been shown to exert their therapeutic effects through the secretion of broad spectrum of paracrine factors, including extracellular vesicles (EVs). Accordingly, EVs are be...

    Authors: María Ángeles de Pedro, Esther López, Francisco Manuel González-Nuño, María Pulido, Verónica Álvarez, Ana María Marchena, Christian Preußer, Witold Szymański, Elke Pogge von Strandmann, Johannes Graumann, Francisco Miguel Sánchez-Margallo, Javier G. Casado and María Gómez-Serrano
    Citation: Stem Cell Research & Therapy 2023 14:187
  37. Acute lung injury is characterized by overwhelmingly elevated PAI-1 in both lung edema fluid and the circulating system. The role of increased PAI-1, encoded by Serpine1 gene, in the regeneration of injured lung ...

    Authors: Gibran Ali, Mo Zhang, Jianjun Chang, Runzhen Zhao, Yang Jin, Jiwang Zhang and Hong-Long Ji
    Citation: Stem Cell Research & Therapy 2023 14:185
  38. Decompensated liver cirrhosis (DLC), a terminal-stage complication of liver disease, is a major cause of morbidity and mortality in patients with hepatopathies. Human umbilical cord mesenchymal stem cell (hUCM...

    Authors: Yunqi Yao, Lin Zhang, Fuyi Cheng, Qingyuan Jiang, Yixin Ye, Yushuang Ren, Yuting He, Dongsheng Su, Lin Cheng, Gang Shi, Lei Dai and Hongxin Deng
    Citation: Stem Cell Research & Therapy 2023 14:184
  39. Atrial fibrillation is the most common arrhythmia syndrome and causes significant morbidity and mortality. Current therapeutics, however, have limited efficacy. Notably, many therapeutics shown to be efficacio...

    Authors: Jordan Thorpe, Matthew D. Perry, Osvaldo Contreras, Emily Hurley, George Parker, Richard P. Harvey, Adam P. Hill and Jamie I. Vandenberg
    Citation: Stem Cell Research & Therapy 2023 14:183
  40. Authors: Sergiy Klid, Francisco Algaba-Chueca, Elsa Maymó-Masip, Albert Guarque, Mónica Ballesteros, Cristina Diaz-Perdigones, Cristina Gutierrez, Joan Vendrell, Ana Megía and Sonia Fernández-Veledo
    Citation: Stem Cell Research & Therapy 2023 14:182

    The original article was published in Stem Cell Research & Therapy 2021 12:608

  41. Mesenchymal stromal cells-derived small extracellular vesicles (MSC-sEVs) have recently attracted considerable attention because of their therapeutic potential in various immune diseases. We previously reporte...

    Authors: Xiao-Qing Liu, Ya-Qi Peng, Long-Xin Huang, Chan-Gu Li, Peng-Peng Kuang, De-Hua Chen, Zi-Cong Wu, Bi-Xin He, Zhi-Rou Zhou and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2023 14:180
  42. Trauma-associated peripheral nerve injury is a widespread clinical problem causing sensory and motor disabilities. Schwann cells (SCs) contribute to nerve regeneration, mainly by secreting nerve growth factor ...

    Authors: Stefania Brambilla, Martino Guiotto, Enrica Torretta, Ilaria Armenia, Matteo Moretti, Cecilia Gelfi, Silvia Palombella and Pietro G. di Summa
    Citation: Stem Cell Research & Therapy 2023 14:179
  43. Preclinical studies showed that mesenchymal stem cells (MSCs) ameliorate tau phosphorylation, amyloid-beta accumulation, and inflammation in Alzheimer’s disease (AD) mouse models via secretion of neurotrophic ...

    Authors: Yejoo Choi, Sungho Shin, Hyo Jin Son, Na-Hee Lee, Su Hyeon Myeong, Cheolju Lee, Hyemin Jang, Soo Jin Choi, Hee Jin Kim and Duk L. Na
    Citation: Stem Cell Research & Therapy 2023 14:178
  44. The osteogenic differentiation capacity of periodontal mesenchymal stem cells (PDLSCs) can be influenced by different levels of static mechanical strain (SMS) in an inflammatory microenvironment. Long non-codi...

    Authors: Xiaochen Zhang, Qing Yan, Xulin Liu, Jie Gao, Yuerong Xu, Zuolin Jin and Wen Qin
    Citation: Stem Cell Research & Therapy 2023 14:177
  45. Dental pulp stem cells (DPSCs) play a crucial role in dentin-pulp complex regeneration. Further understanding of the mechanism by which DPSCs remain in a quiescent state could contribute to improvements in the...

    Authors: Xinghong Luo, Weiqing Feng, Shijiang Huang, Shenghong Miao, Tao Jiang, Qian Lei, Jingyao Yin, Sheng Zhang, Xiaochun Bai, Chunbo Hao, Weizhong Li and Dandan Ma
    Citation: Stem Cell Research & Therapy 2023 14:176

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