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  1. Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations after spinal cord injury (SCI). Understanding the molecular even...

    Authors: Francisco Javier Rodriguez-Jimenez, Pavla Jendelova and Slaven Erceg
    Citation: Stem Cell Research & Therapy 2023 14:175
  2. Critical limb ischemia (CLI) is associated with increased risk of tissue loss, leading to significant morbidity and mortality. Therapeutic angiogenesis using cell-based treatments, notably mesenchymal stem cel...

    Authors: Zeinab Shirbaghaee, Saeed Heidari Keshel, Mehdi Rasouli, Majid Valizadeh, Seyed Saeed Hashemi Nazari, Mohammad Hassani and Masoud Soleimani
    Citation: Stem Cell Research & Therapy 2023 14:174
  3. Polyploid cells can be found in a wide evolutionary spectrum of organisms. These cells are assumed to be involved in tissue regeneration and resistance to stressors. Although the appearance of large multinucle...

    Authors: Shiva Moein, Naser Ahmadbeigi, Rezvan Adibi, Sara Kamali, Kobra Moradzadeh, Pardis Nematollahi, Nance Beyer Nardi and Yousof Gheisari
    Citation: Stem Cell Research & Therapy 2023 14:173
  4. Islet transplantation is used therapeutically in a minority of patients with type 1 diabetes (T1D). However, successful outcomes are hampered by early islet β-cell loss caused by immune rejection and autoimmun...

    Authors: Mingxing Sui, Tuo Li, Hanlan Lu, Yanhua Li, Juan Huang, Pei Zhang, Shusen Wang and Li Zeng
    Citation: Stem Cell Research & Therapy 2023 14:172
  5. Ferroptosis is an iron-related form of programmed cell death. Accumulating evidence has identified the pathogenic role of ferroptosis in multiple orthopedic disorders. However, the relationship between ferropt...

    Authors: Wenming Li, Wenhao Li, Wei Zhang, Hongzhi Wang, Lei Yu, Peng Yang, Yi Qin, Minfeng Gan, Xing Yang, Lixin Huang, Yuefeng Hao and Dechun Geng
    Citation: Stem Cell Research & Therapy 2023 14:171
  6. Brainstem stroke causes severe and persistent neurological impairment. Due to the limited spontaneous recovery and regeneration of the disrupted neural circuits, transplantation of exogenous neural stem cells ...

    Authors: Xiangyue Tang, Li Wu, Juehua Zhu, Mindong Xu, Shaojun Li, Guanfeng Zeng, Shuanggen Zhu and Yongjun Jiang
    Citation: Stem Cell Research & Therapy 2023 14:170
  7. The main causes of death in patients with severe Coronavirus disease-2019 (COVID-19) are acute respiratory distress syndrome (ARDS) and multiorgan failure caused by a severe inflammatory cascade. Novel treatme...

    Authors: Morteza Zarrabi, Mohammad Amin Shahrbaf, Masoumeh Nouri, Faezeh Shekari, Seyedeh-Esmat Hosseini, Seyed-Mohammad Reza Hashemian, Rasoul Aliannejad, Hamidreza Jamaati, Naghmeh Khavandgar, Hediyeh Alemi, Hoda Madani, Abdoreza Nazari, Azadeh Amini, Seyedeh Nafiseh Hassani, Fatemeh Abbasi, Neda Jarooghi…
    Citation: Stem Cell Research & Therapy 2023 14:169
  8. Osteoarthritis (OA) is a chronic debilitating disease impacting a significant percentage of the global population. While there are numerous surgical and non-invasive interventions that can postpone joint repla...

    Authors: Roman J. Krawetz, Leila Larijani, Jessica May Corpuz, Nicoletta Ninkovic, Nabangshu Das, Alexandra Olsen, Nicholas Mohtadi, Alexander Rezansoff and Antoine Dufour
    Citation: Stem Cell Research & Therapy 2023 14:168
  9. Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Transplantation of immunosuppressive human mesenchymal stromal cells (hM...

    Authors: Stanley Chun Ming Wu, Manyu Zhu, Stanley C. C. Chik, Maxwell Kwok, Asif Javed, Laalaa Law, Shing Chan, Kenneth R. Boheler, Yin Ping Liu, Godfrey Chi Fung Chan and Ellen Ngar-Yun Poon
    Citation: Stem Cell Research & Therapy 2023 14:167
  10. Age-associated bone diseases such as osteoporosis (OP) are common in the elderly due to skeletal ageing. The process of skeletal ageing can be accelerated by reduced proliferation and osteogenesis of bone marr...

    Authors: Yujue Li, Mingxing Hu, Jinwei Xie, Shuangqing Li and Lunzhi Dai
    Citation: Stem Cell Research & Therapy 2023 14:166
  11. Primary ovarian insufficiency (POI) refers to the loss of ovarian function under the age of 40 and results in amenorrhea and infertility. Our previous studies have shown that transplantation of mesenchymal ste...

    Authors: Hang-soo Park, Rishi Man Chugh, Jin Seok, Esra Cetin, Hanaa Mohammed, Hiba Siblini, Farzana Liakath Ali, Mohammad Mousaei Ghasroldasht, Hiba Alkelani, Amro Elsharoud, Mara Ulin, Sahar Esfandyari and Ayman Al-Hendy
    Citation: Stem Cell Research & Therapy 2023 14:165
  12. Owing to the advances in genome editing technologies, research on human pluripotent stem cells (hPSCs) have recently undergone breakthroughs that enable precise alteration of desired nucleotide bases in hPSCs ...

    Authors: Ju-Chan Park, Mihn Jeong Park, Seung-Yeon Lee, Dayeon Kim, Keun-Tae Kim, Hyeon-Ki Jang and Hyuk-Jin Cha
    Citation: Stem Cell Research & Therapy 2023 14:164
  13. Chronic refractory wounds easily relapse and seriously affect the patients’ quality of life. Previous studies have shown that stromal vascular fraction gel (SVF-gel) significantly promotes the early healing of...

    Authors: Yuan Cai, Fang Zhang, Jingwei Feng, Bihua Wu, Hai Li, Shune Xiao, Feng Lu, Zairong Wei and Chengliang Deng
    Citation: Stem Cell Research & Therapy 2023 14:163
  14. Intra-articular injection of mesenchymal stromal cells (MSCs) with immunomodulatory features and their paracrine secretion of regenerative factors proposed a noninvasive therapeutic modality for cartilage rege...

    Authors: Bahareh Sadri, Mohammad Hassanzadeh, Abolfazl Bagherifard, Javad Mohammadi, Mehdi Alikhani, Kasra Moeinabadi-Bidgoli, Hoda Madani, Dylana Diaz-Solano, Shahedeh Karimi, Mohammad Mehrazmay, Mehdi Mohammadpour and Massoud Vosough
    Citation: Stem Cell Research & Therapy 2023 14:162
  15. The epicardium is the important outermost mesothelial/epithelial layer of the heart that serves as a signaling center for cardiac development and repair. During heart development, epicardial cells undergo a pr...

    Authors: Zibei Gao, Zhengkai Lu, Jinyan Meng, Chao-Po Lin, Hui Zhang and Juan Tang
    Citation: Stem Cell Research & Therapy 2023 14:161
  16. Autologous chondrocyte implantation (ACI) has been used to treat articular cartilage defects for over two decades. Adult stem cells have been proposed as a solution to inadequate donor cell numbers often encou...

    Authors: Yangzi Jiang and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2023 14:160
  17. Mesenchymal stem cell (MSC) therapy is an attractive treatment option for various cancers. Whether MSCs can be used to treat well-differentiated endometrial cancer (EC) remains unclear. The aim of this study i...

    Authors: Yuhui Xu, Jiali Hu, Qiaoying Lv, Chenyi Shi, Mengdi Qiu, Liying Xie, Wei Liu, Bingyi Yang, Weiwei Shan, Yali Cheng, Bing Zhao and Xiaojun Chen
    Citation: Stem Cell Research & Therapy 2023 14:159
  18. Cardiomyocytes derived from pluripotent stem cells (PSC-CMs) have been widely accepted as a promising cell source for cardiac drug screening and heart regeneration therapies. However, unlike adult cardiomyocyt...

    Authors: Qianqian Ding, Xianji Liu, Yanxiang Qi, Xiaoqiang Yao and Suk Ying Tsang
    Citation: Stem Cell Research & Therapy 2023 14:158
  19. Due to the limited accessibility of the in vivo situation, the scarcity of the human tissue, legal constraints, and ethical considerations, the underlying molecular mechanisms of disorders, such as preeclampsi...

    Authors: Margit Rosner, Stefanie Horer, Michael Feichtinger and Markus Hengstschläger
    Citation: Stem Cell Research & Therapy 2023 14:157
  20. Robust and reliable in vitro and in vivo models of primary cells are necessary to study the pathomechanisms of Myelodysplastic Neoplasms (MDS) and identify novel therapeutic strategies. MDS-derived hematopoiet...

    Authors: Eva Altrock, Carla Sens-Albert, Franziska Hofmann, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Johann-Christoph Jann, Felicitas Rapp, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Ali Darwich…
    Citation: Stem Cell Research & Therapy 2023 14:156
  21. Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and multilineage potency. Also, they secret a diversity of mediators, wh...

    Authors: Mohammad Saeed Kahrizi, Elnaz Mousavi, Armin Khosravi, Sara Rahnama, Ali Salehi, Navid Nasrabadi, Farnoosh Ebrahimzadeh and Samira Jamali
    Citation: Stem Cell Research & Therapy 2023 14:155
  22. Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and cardiomyocytes. However, translation of ...

    Authors: Nerea Cuesta-Gomez, Kevin Verhoeff, Nidheesh Dadheech, Tiffany Dang, Ila Tewari Jasra, Mario Bermudez de Leon, Rena Pawlick, Braulio Marfil-Garza, Perveen Anwar, Haide Razavy, Patricio Adrián Zapata-Morin, Glen Jickling, Aducio Thiesen, Doug O’Gorman, Michael S. Kallos and A. M. James Shapiro
    Citation: Stem Cell Research & Therapy 2023 14:154
  23. Adipose tissue is known to serve as an abundant and readily accessible source of adipose-derived stem cells (ADSCs) as an alternative to bone marrow. Collagenase is one of the most widely used methods for the ...

    Authors: Joo-Hoo Park, Yujin Choi, Jae-Min Shin, Hyun-Woo Yang, Seong-Ho Jeong and Il-Ho Park
    Citation: Stem Cell Research & Therapy 2023 14:153
  24. Adult hematopoietic stem cells (HSCs) in the bone marrow (BM) are quiescent. Following perturbations, such as blood loss or infection, HSCs may undergo activation. Surprisingly, little is known about the earli...

    Authors: Roshina Thapa, Erez Elfassy, Leonid Olender, Omri Sharabi and Roi Gazit
    Citation: Stem Cell Research & Therapy 2023 14:152
  25. Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have been proposed as an alternative to cell therapy, creating new possible delivery modalities such as nebulisation. We wished to investigate t...

    Authors: Hector Gonzalez, Sean McCarthy, Claire Masterson, Declan Byrnes, Ignacio Sallent, Emma Horan, Stephen J. Elliman, Gabriele Vella, Adriele Prina-Mello, Johnatas D. Silva, Anna D. Krasnodembskaya, Ronan MacLoughlin, John G. Laffey and Daniel O’Toole
    Citation: Stem Cell Research & Therapy 2023 14:151
  26. Sulfur mustard (SM) is a highly toxic chemical warfare agent that has caused numerous casualties during wars and conflicts in the past century. Specific antidotes or therapeutic strategies are rare due to the ...

    Authors: Zhipeng Pei, Jinfeng Cen, Xinkang Zhang, Chuchu Gong, Mingxue Sun, Wenqi Meng, Guanchao Mao, Jingjing Wan, Bingyue Hu, Xiaowen He, Qingqiang Xu, Hua Han and Kai Xiao
    Citation: Stem Cell Research & Therapy 2023 14:149
  27. Exosomes play important roles in intercellular communication by delivering microRNAs (miRNAs) that mediate tumor initiation and development, including those in diffuse large B cell lymphoma (DLBCL). To date, h...

    Authors: Xiaoxuan Zhao, Mingxi Xu, Xuemeng Hu, Xiaolei Ding, Xian Zhang, Liye Xu, Li Li, Xiuhua Sun and Jincheng Song
    Citation: Stem Cell Research & Therapy 2023 14:148
  28. Atopic dermatitis (AD) is one of the most common immune and inflammatory skin disorders, leading to insufferable itching and skin abnormalities that seriously affect life quality of patients. There are still h...

    Authors: Chunting Hua, Qichang Liang, Siji Chen, Jiang Zhu, Yi Tang, Xianzhen Chen, Yinjing Song, Stijn van der Veen and Hao Cheng
    Citation: Stem Cell Research & Therapy 2023 14:147
  29. Diabetic nephropathy (DN) is one of the most severe complications of diabetes mellitus, which is characterized by early occurrence of albuminuria and end-stage glomerulosclerosis. Senescence and autophagy of p...

    Authors: Xinyue Li, Le Guo, Jingan Chen, Haowei Liang, Yi Liu, Wei Chen, Li Zhou, Letian Shan and Hui Wang
    Citation: Stem Cell Research & Therapy 2023 14:146
  30. Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer pr...

    Authors: Wen Hu, Ruisong Ding, Mengyang Wang, Panpan Huang, Xia Wei, Xingyou Hu and Tao Hu
    Citation: Stem Cell Research & Therapy 2023 14:145
  31. Metformin as a first-line clinical anti-diabetic agent prolongs the lifespan of model animals and promotes cell proliferation. However, the molecular mechanisms underlying the proliferative phenotype, especial...

    Authors: Xiang Wang, Geng G. Tian, Weiwei Cheng, Xiaoli Yu, Xiaoyong Li and Ji Wu
    Citation: Stem Cell Research & Therapy 2023 14:144
  32. Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs). Mechanisms directing obesity-induced phen...

    Authors: Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, Kamalnath Sankaran Rajagopalan, Samer H. Barsom, Roman Thaler, Sarosh Siddiqi, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Andre J. van Wijnen, Alfonso Eirin and Lilach O. Lerman
    Citation: Stem Cell Research & Therapy 2023 14:143
  33. There is a growing body of evidence that multipotent mesenchymal stromal cells’ (MSCs’) remarkable therapeutic potential is attributed not only to their differentiation and regenerative capacity, but also to t...

    Authors: Maria Peshkova, Alexander Korneev, Shakir Suleimanov, Irina I. Vlasova, Andrey Svistunov, Nastasia Kosheleva and Peter Timashev
    Citation: Stem Cell Research & Therapy 2023 14:142
  34. Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50% or more. Although liver transplantation has emerged as the most efficient treatment for end-stage liver disease, its ...

    Authors: Xin-Hao Hu, Lan Chen, Hao Wu, Yang-Bo Tang, Qiu-Min Zheng, Xu-Yong Wei, Qiang Wei, Qi Huang, Jian Chen and Xiao Xu
    Citation: Stem Cell Research & Therapy 2023 14:141
  35. The dermal papilla cells are a specialized population of mesenchymal cells located at the base of the hair follicle (HF), which possess the capacity to regulate HF morphogenesis and regeneration. However, lack...

    Authors: Lijuan Du, Yuyang Gan, Bowen Zheng, Junfei Huang, Zhiqi Hu and Yong Miao
    Citation: Stem Cell Research & Therapy 2023 14:140
  36. Blood transfusions represent common medical procedures, which provide essential supportive therapy. However, these procedures are notoriously expensive for healthcare services and not without risk. The potenti...

    Authors: Christian Felice Cervellera, Chiara Mazziotta, Giulia Di Mauro, Maria Rosa Iaquinta, Elisa Mazzoni, Elena Torreggiani, Mauro Tognon, Fernanda Martini and John Charles Rotondo
    Citation: Stem Cell Research & Therapy 2023 14:139
  37. Liver damage caused by toxicity can lead to various severe conditions, such as acute liver failure (ALF), fibrogenesis, and cirrhosis. Among these, liver cirrhosis (LC) is recognized as the leading cause of li...

    Authors: Farnaz Sani, Mahsa Sani, Zahra Moayedfard, Maryam Darayee, Lobat Tayebi and Negar Azarpira
    Citation: Stem Cell Research & Therapy 2023 14:138
  38. Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute...

    Authors: Kelly Warmink, Jaqueline L. Rios, Suzy Varderidou-Minasian, Marta Torres-Torrillas, Devin R. van Valkengoed, Sabine Versteeg, Niels Eijkelkamp, Harrie Weinans, Nicoline M. Korthagen and Magdalena J. Lorenowicz
    Citation: Stem Cell Research & Therapy 2023 14:137
  39. Intrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is often inhibited by deleterious immune responses to donor cells resulting in subtherapeu...

    Authors: Karthikeyan Kandasamy, Nuryanti Binti Johana, Lay Geok Tan, Yvonne Tan, Julie Su Li Yeo, Nur Nazneen Binte Yusof, Zhihui Li, Jiayu Koh, Florent Ginhoux, Jerry K. Y. Chan, Mahesh Choolani and Citra N. Z. Mattar
    Citation: Stem Cell Research & Therapy 2023 14:136
  40. Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very complex, which is closely related to genes, immune diseases, drugs, surgery, and psycho...

    Authors: Fangfang Dai, Ruiqi Wang, Zhimin Deng, Dongyong Yang, Linlin Wang, Mali Wu, Wei Hu and Yanxiang Cheng
    Citation: Stem Cell Research & Therapy 2023 14:135
  41. Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat livers treated with retrorsine (Ret) that underwent 70% partial hepatectomy (PH). We previo...

    Authors: Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi and Toshihiro Mitaka
    Citation: Stem Cell Research & Therapy 2023 14:134
  42. Electromagnetic fields (EMF) are increasing in popularity as a safe and non-invasive therapy. On the one hand, it is widely acknowledged that EMF can regulate the proliferation and differentiation of stem cell...

    Authors: Tian Ma, Qing Ding, Chaoxu Liu and Hua Wu
    Citation: Stem Cell Research & Therapy 2023 14:133
  43. Human adult dental pulp stem cells (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) hold promise in bone regeneration for their easy accessibility, high proliferation rate, self-renewal and ...

    Authors: Amin Namjoynik, Md Asiful Islam and Mohammad Islam
    Citation: Stem Cell Research & Therapy 2023 14:132
  44. Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied by cerebral edema, inflammation, and subsequent neurological deficits. Mesenchymal stem cells (MSCs) transplantation has been used a...

    Authors: Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Xue Bai, Yuanxia Zou, Honglian Wang, Bingfeng Huang, Sijing Yang, Nathupakorn Dechsupa and Li Wang
    Citation: Stem Cell Research & Therapy 2023 14:131
  45. Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3), a secreted multifunctional glycoprotein whose transcript expression is restricted to the tooth germ epithelium during the development of embryonic m...

    Authors: Zijie Wang, Chuying Chen, Jiayi Zhang, Jiangdie He, Lin Zhang, Jiayuan Wu and Zhihui Tian
    Citation: Stem Cell Research & Therapy 2023 14:130
  46. Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also kn...

    Authors: Kuin Tian Pang, Larry Sai Weng Loo, Sean Chia, Francesca Yi Teng Ong, Hanry Yu and Ian Walsh
    Citation: Stem Cell Research & Therapy 2023 14:129
  47. Greater knowledge of mesenchymal stromal cell (MSC)-based therapies is driving the research into their secretome, identified as the main element responsible for their therapeutic effects. The aim of this study...

    Authors: Vito Antonio Baldassarro, Francesca Perut, Maura Cescatti, Valentina Pinto, Nicola Fazio, Giuseppe Alastra, Valentina Parziale, Alessandra Bassotti, Mercedes Fernandez, Luciana Giardino, Nicola Baldini and Laura Calzà
    Citation: Stem Cell Research & Therapy 2023 14:128
  48. Childhood cancer treatment-induced gonadotoxicity causes permanent infertility/sub-infertility in nearly half of males. The current clinical and experimental approaches are limited to cryopreservation of prepu...

    Authors: Selin Önen, Ali Can Atik, Merve Gizer, Sevil Köse, Önder Yaman, Haluk Külah and Petek Korkusuz
    Citation: Stem Cell Research & Therapy 2023 14:127
  49. Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high...

    Authors: Sijia Li, Lihua Dong, Zhenyu Pan and Guozi Yang
    Citation: Stem Cell Research & Therapy 2023 14:125

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