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  1. The existence of cancer stem cells (CSCs) has been associated with tumor initiation, therapy resistance, tumor relapse, angiogenesis, and metastasis. Curcumin, a plant ployphenol, has several anti-tumor effect...

    Authors: Shravanti Mukherjee, Minakshi Mazumdar, Samik Chakraborty, Argha Manna, Shilpi Saha, Poulami Khan, Pushpak Bhattacharjee, Deblina Guha, Arghya Adhikary, Sanhita Mukhjerjee and Tanya Das
    Citation: Stem Cell Research & Therapy 2014 5:116
    Content type: Research Published on:

  2. Repair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential fo...

    Authors: Meadhbh Á Brennan, Audrey Renaud, Jérôme Amiaud, Markus T Rojewski, Hubert Schrezenmeier, Dominique Heymann, Valerie Trichet and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2014 5:114
    Content type: Research Published on:

  3. Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cel...

    Authors: Angela Fülbier, Reinhild Schnabel, Stefanie Michael, Peter M Vogt, Sarah Strauß, Kerstin Reimers and Christine Radtke
    Citation: Stem Cell Research & Therapy 2014 5:113
    Content type: Research Published on:

  4. Mesenchymal stem cells have been increasingly used for cell-based therapies. Adipose-derived stem/stromal cells (ASCs) from the stromal vascular fraction (SVF) of fat tissue are a particularly attractive optio...

    Authors: Hetal D Marble, Bryan A Sutermaster, Manisha Kanthilal, Vera C Fonseca and Eric M Darling
    Citation: Stem Cell Research & Therapy 2014 5:145
    Content type: Research Published on:

  5. Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative...

    Authors: Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger
    Citation: Stem Cell Research & Therapy 2014 5:100
    Content type: Research Published on:

  6. Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in the treatment of myocardial infarction. We showed recently that hypoxia precondi...

    Authors: Xian-Bao Liu, Jian-An Wang, Xiao-Ya Ji, Shan Ping Yu and Ling Wei
    Citation: Stem Cell Research & Therapy 2014 5:111
    Content type: Research Published on:

  7. Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac...

    Authors: Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jian Li, William R Birch, Shaul Reuveny and Steve Kah-Weng Oh
    Citation: Stem Cell Research & Therapy 2014 5:110
    Content type: Research Published on:

  8. Asthma is characterized by a chronic inflammatory process which may lead to several changes in bone marrow cell composition. We hypothesized that bone marrow mononuclear cells (BMMCs) obtained from ovalbumin (...

    Authors: Soraia C Abreu, Mariana A Antunes, Lucas Mendonça, Vivian C Branco, Elga Bandeira de Melo, Priscilla C Olsen, Bruno L Diaz, Daniel J Weiss, Bruno D Paredes, Debora G Xisto, Marcelo M Morales and Patricia RM Rocco
    Citation: Stem Cell Research & Therapy 2014 5:108
    Content type: Research Published on:

  9. Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lun...

    Authors: Courtney A McDonald, Jacqueline M Melville, Graeme R Polglase, Graham Jenkin and Timothy JM Moss
    Citation: Stem Cell Research & Therapy 2014 5:107
    Content type: Research Published on:

  10. Despite numerous research efforts, mechanisms underlying regeneration of pancreas remains controversial. Views are divided whether stem cells are involved during pancreatic regeneration or it involves duplicat...

    Authors: Deepa Bhartiya, Akash Mundekar, Vaibhav Mahale and Hiren Patel
    Citation: Stem Cell Research & Therapy 2014 5:106
    Content type: Research Published on:

  11. Osteoporosis is a disease characterized by low bone mineral density (BMD) and increased risk of fractures. Studies have demonstrated the use of phytoestrogens, or plant-derived estrogens, such as genistein and...

    Authors: Amy L Strong, Jason F Ohlstein, Quan Jiang, Qiang Zhang, Shilong Zheng, Stephen M Boue, Steven Elliott, Jeffrey M Gimble, Matthew E Burow, Guangdi Wang and Bruce A Bunnell
    Citation: Stem Cell Research & Therapy 2014 5:105
    Content type: Research Published on:

  12. Mesenchymal stem cells (MSCs) have the ability to repair and regenerate tissue, home to sites of inflammation, and evade the host immune system. As such, they represent an attractive therapy for the treatment ...

    Authors: Catherine B Sullivan, Ryan M Porter, Chris H Evans, Thomas Ritter, Georgina Shaw, Frank Barry and Josephine Mary Murphy
    Citation: Stem Cell Research & Therapy 2014 5:104
    Content type: Research Published on:

  13. The transplantation of genetically modified progenitor cells such as bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the natural healing of articular cartilage defects. I...

    Authors: Janina Frisch, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Henning Madry and Magali Cucchiarini
    Citation: Stem Cell Research & Therapy 2014 5:103
    Content type: Research Published on:

  14. The objective of this work was to evaluate the efficacy of placenta-derived mesenchymal stem cell (MSC) therapy in a mouse model of myocardial infarction (MI). Since MSCs can be obtained from two different reg...

    Authors: Juliana A Passipieri, Tais H Kasai-Brunswick, Grazielle Suhett, Andreza B Martins, Guilherme V Brasil, Dilza B Campos, Nazareth N Rocha, Isalira P Ramos, Debora B Mello, Deivid C Rodrigues, Beatriz B Christie, Bernardo J Silva-Mendes, Alex Balduíno, Renato M Sá, Laudelino M Lopes, Regina C Goldenberg…
    Citation: Stem Cell Research & Therapy 2014 5:102
    Content type: Research Published on:

  15. Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection o...

    Authors: Li Xing, Rui Cui, Lei Peng, Jing Ma, Xiao Chen, Ru-Juan Xie and Bing Li
    Citation: Stem Cell Research & Therapy 2014 5:101
    Content type: Research Published on:

  16. Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo mainly t...

    Authors: Gi-Shih Lien, Jen-Fang Liu, Ming-Hsien Chien, Wei-Tse Hsu, Tzu-Hao Chang, Chia-Chi Ku, Andrea Tung-Qian Ji, Peng Tan, Ting-Lieh Hsieh, Liang-Ming Lee and Jennifer H Ho
    Citation: Stem Cell Research & Therapy 2014 5:97
    Content type: Research Published on:

  17. Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of these ce...

    Authors: Benjamin A Kansy, Philip A Dißmann, Hatim Hemeda, Kirsten Bruderek, Anna M Westerkamp, Vivien Jagalski, Patrick Schuler, Katinka Kansy, Stephan Lang, Claudia A Dumitru and Sven Brandau
    Citation: Stem Cell Research & Therapy 2014 5:95
    Content type: Research Published on:

  18. Autologous mesenchymal stem cell (MSC) injection into naturally-occurring equine tendon injuries has been shown to be safe and efficacious and protocols inform translation of the technique into humans. Efficie...

    Authors: Elaine R Garvican, Sandra Cree, Lydia Bull, Roger KW Smith and Jayesh Dudhia
    Citation: Stem Cell Research & Therapy 2014 5:1
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:161

  19. The optimal cell lineage for cardiac-regeneration approaches remains mysterious. Additionally, electrical stimulation promotes cardiomyogenic differentiation of stimulated cells. Therefore, we hypothesized tha...

    Authors: Aida Llucià-Valldeperas, Benjamin Sanchez, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Javier Rosell-Ferrer, Ramon Bragos and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2014 5:93
    Content type: Short Report Published on:

  20. Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal...

    Authors: Xiaoming Wang, Hui Zhang, Liangming Nie, Linhai Xu, Min Chen and Zhaoping Ding
    Citation: Stem Cell Research & Therapy 2014 5:92
    Content type: Research Published on:

  21. Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection of allogen...

    Authors: Yasmin Z Paterson, Nicola Rash, Elaine R Garvican, Romain Paillot and Deborah J Guest
    Citation: Stem Cell Research & Therapy 2014 5:90
    Content type: Research Published on:

  22. Mesenchymal stromal/stem cells (MSCs) for clinical use have largely been isolated from the bone marrow, although isolation of these cells from many different adult and fetal tissues has been reported as well. ...

    Authors: Priyanka Swamynathan, Parvathy Venugopal, Suresh Kannan, Charan Thej, Udaykumar Kolkundar, Swaroop Bhagwat, Malancha Ta, Anish Sen Majumdar and Sudha Balasubramanian
    Citation: Stem Cell Research & Therapy 2014 5:88
    Content type: Research Published on:

  25. New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promis...

    Authors: Daniela Nascimento Silva, Bruno Solano de Freitas Souza, Carine Machado Azevedo, Juliana Fraga Vasconcelos, Rejane Hughes Carvalho, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos
    Citation: Stem Cell Research & Therapy 2014 5:81
    Content type: Research Published on:

  26. The mortality of rhabdomyolysis-induced acute kidney injury (AKI) is still high, as there is no effective therapy. It has been shown that bone marrow-derived mesenchymal stem cells (MSCs) can induce M2 macroph...

    Authors: Yanqiu Geng, Li Zhang, Bo Fu, Jianrong Zhang, Quan Hong, Jie Hu, Diangeng Li, Congjuan Luo, Shaoyuan Cui, Fei Zhu and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2014 5:80
    Content type: Research Published on:

  27. Pathophysiologic changes associated with diabetes impair new blood vessel formation and wound healing. Mesenchymal stem cells derived from adipose tissue (ASCs) have been used clinically to promote healing, al...

    Authors: Robert C Rennert, Michael Sorkin, Michael Januszyk, Dominik Duscher, Revanth Kosaraju, Michael T Chung, James Lennon, Anika Radiya-Dixit, Shubha Raghvendra, Zeshaan N Maan, Michael S Hu, Jayakumar Rajadas, Melanie Rodrigues and Geoffrey C Gurtner
    Citation: Stem Cell Research & Therapy 2014 5:79
    Content type: Research Published on:

  28. The optimization of an organic scaffold for specific types of applications and cells is vital to successful tissue engineering. In this study, we investigated the effects of a new fibrin sealant derived from s...

    Authors: Vinícius P O Gasparotto, Fernanda C Landim-Alvarenga, Alexandre L R Oliveira, Gustavo Ferreira Simões, João F Lima-Neto, Benedito Barraviera and Rui S Ferreira Jr
    Citation: Stem Cell Research & Therapy 2014 5:78
    Content type: Research Published on:

  29. In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiati...

    Authors: Michaela Leyh, Andreas Seitz, Lutz Dürselen, Hans-Robert Springorum, Peter Angele, Anita Ignatius, Joachim Grifka and Susanne Grässel
    Citation: Stem Cell Research & Therapy 2014 5:77
    Content type: Research Published on:

  30. Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to have protective effects against various cellular-injury models. This mechanism of protection, however, has yet to be elucidated. Recently, ex...

    Authors: Cheau Yih Tan, Ruenn Chai Lai, Winnie Wong, Yock Young Dan, Sai-Kiang Lim and Han Kiat Ho
    Citation: Stem Cell Research & Therapy 2014 5:76
    Content type: Research Published on:

  31. Posttranscriptional control of mRNA by microRNA (miRNA) has been implicated in the regulation of diverse biologic processes from directed differentiation of stem cells through organism development. We describe...

    Authors: Vilas Wagh, Alexander Pomorski, Karlijn J Wilschut, Sebastian Piombo and Harold S Bernstein
    Citation: Stem Cell Research & Therapy 2014 5:75
    Content type: Research Published on:

  32. Mesenchymal stem cells (MSCs) reside in a variety of tissues and provide a stromal role in regulating progenitor cell function. Current studies focus on identifying the specific factors in the niche that can a...

    Authors: Michael De Lisio, Tor Jensen, Richard A Sukiennik, Heather D Huntsman and Marni D Boppart
    Citation: Stem Cell Research & Therapy 2014 5:74
    Content type: Research Published on:

  33. Insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs) and angiopoietin-like proteins (ANGPTLs) can enhance the ex vivo expansion of hematopoietic stem cells (HSCs) when used with a standard cytokine c...

    Authors: Xiubo Fan, Florence PH Gay, Francesca WI Lim, Justina ML Ang, Pat PY Chu, Sudipto Bari and William YK Hwang
    Citation: Stem Cell Research & Therapy 2014 5:71
    Content type: Research Published on:

  34. We have assessed the utility of autologous mesenchymal stem cell (MSC) peripheral vein infusion as a possible therapeutic modality for patients with end-stage liver diseases.

    Authors: Hosny Salama, Abdel-Rahman N Zekri, Eman Medhat, Shereen A Al Alim, Ola S Ahmed, Abeer A Bahnassy, Mai M Lotfy, Rasha Ahmed and Sherief Musa
    Citation: Stem Cell Research & Therapy 2014 5:70
    Content type: Research Published on:

  35. Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells...

    Authors: Chenghua Li, Bei Li, Zhiwei Dong, Li Gao, Xiaoning He, Li Liao, Chenghu Hu, Qintao Wang and Yan Jin
    Citation: Stem Cell Research & Therapy 2014 5:67
    Content type: Research Published on:

  36. Bone marrow mesenchymal stem cells (BMSCs) possess low immunogenicity and immunosuppression as an allograft, can differentiate into insulin-producing cells (IPCs) by in vitro induction, and may be a valuable cell...

    Authors: Yihua Zhang and Zhongying Dou
    Citation: Stem Cell Research & Therapy 2014 5:66
    Content type: Research Published on:

  37. This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative ...

    Authors: Eva Koellensperger, Felix Gramley, Fabian Preisner, Uwe Leimer, Guenter Germann and Verena Dexheimer
    Citation: Stem Cell Research & Therapy 2014 5:65
    Content type: Research Published on:

  38. Npas4 is a calcium-dependent transcription factor expressed within neurons of the brain where it regulates the expression of several genes that are important for neuronal survival and synaptic plasticity. It i...

    Authors: Thomas S Klaric, Paul Q Thomas, Mirella Dottori, Wai Khay Leong, Simon A Koblar and Martin D Lewis
    Citation: Stem Cell Research & Therapy 2014 5:64
    Content type: Research Published on:

  39. Human adipose-derived stromal cells (hASCs), due to their relative feasibility of isolation and ability to secrete large amounts of angiogenic factors, are being evaluated for regenerative medicine. However, t...

    Authors: Luigi Balducci, Antonella Blasi, Marilisa Saldarelli, Antonio Soleti, Augusto Pessina, Arianna Bonomi, Valentina Coccè, Marta Dossena, Valentina Tosetti, Valentina Ceserani, Stefania Elena Navone, Maria Laura Falchetti, Eugenio Agostino Parati and Giulio Alessandri
    Citation: Stem Cell Research & Therapy 2014 5:63
    Content type: Research Published on:

  41. We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. This technique has proven to be...

    Authors: Sandra Chapman, David H McDermott, Kui Shen, Moon Kyoo Jang and Alison A McBride
    Citation: Stem Cell Research & Therapy 2014 5:60
    Content type: Research Published on:

  42. Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue en...

    Authors: Ian H Bellayr, Jennifer G Catalano, Samir Lababidi, Amy X Yang, Jessica L Lo Surdo, Steven R Bauer and Raj K Puri
    Citation: Stem Cell Research & Therapy 2014 5:59
    Content type: Research Published on:

  43. Stem cell therapy has recently been introduced to treat patients with type 2 diabetes mellitus (T2DM). However, no data are available on the efficacy and safety of allogeneic Wharton’s Jelly-derived mesenchyma...

    Authors: Xuebin Liu, Pei Zheng, Xiaodong Wang, Guanghui Dai, Hongbin Cheng, Zan Zhang, Rongrong Hua, Xinxin Niu, Jing Shi and Yihua An
    Citation: Stem Cell Research & Therapy 2014 5:57
    Content type: Research Published on:

  44. The cancer stem cell model links neoplastic cells with normal stem cell biology, but little is known on how normal stem cells are transformed into cancer stem cells.

    Authors: Donatella Amendola, Marta Nardella, Loredana Guglielmi, Lidia Cerquetti, Elisabetta Carico, Viola Alesi, Manuela Porru, Carlo Leonetti, Claudia Bearzi, Roberto Rizzi, Igea D’Agnano, Antonio Stigliano, Giuseppe Novelli and Barbara Bucci
    Citation: Stem Cell Research & Therapy 2014 5:55
    Content type: Research Published on:

  45. Although mesenchymal stem cells (MSCs) have antitumor potential in hepatocellular carcinoma and breast cancer cells, the antitumor mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) in prostate...

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim
    Citation: Stem Cell Research & Therapy 2014 5:54
    Content type: Research Published on:

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2018 9:354

  46. Different mesenchymal stromal cells (MSC) have been successfully isolated and expanded in vitro and nowadays they are tested in clinical trials for a wide variety of diseases. Whether all MSC express the same cel...

    Authors: Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2014 5:53
    Content type: Research Published on:

  47. Gingiva-derived mesenchymal stem cells (GMSCs) have recently been harvested and applied for rebuilding lost periodontal tissue. Enamel matrix derivative (EMD) has been used for periodontal regeneration and the...

    Authors: Shu-Man Wu, Hsien-Chung Chiu, Yu-Tang Chin, Heng-Yi Lin, Cheng-Yang Chiang, Hsiao-Pei Tu, Martin MJ Fu and Earl Fu
    Citation: Stem Cell Research & Therapy 2014 5:52
    Content type: Research Published on:

  48. Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer’s disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the under...

    Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A Castello, Andranik A Agazaryan, Joy L Davis, Franz-Josef Müller, Jeanne F Loring, Eliezer Masliah and Frank M LaFerla
    Citation: Stem Cell Research & Therapy 2014 5:46
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:88

  49. Adipose tissue has the unique property of expanding throughout adult life, and angiogenesis is required for its growth. However, endothelial progenitor cells contribute minimally to neovascularization. Because...

    Authors: Amparo Navarro, Severiano Marín, Nicasia Riol, Francisco Carbonell-Uberos and María Dolores Miñana
    Citation: Stem Cell Research & Therapy 2014 5:50
    Content type: Research Published on:
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ISSN: 1757-6512