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  1. Research

    Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

    Autosomal dominant polycystic kidney disease (ADPKD) is a genetic ciliopathy disease characterized by progressive formation and enlargement of cysts in multiple organs. The kidneys are particularly affected an...

    Atieh Makhlough, Soroosh Shekarchian, Reza Moghadasali, Behzad Einollahi, Seyedeh Esmat Hosseini, Neda Jaroughi, Tina Bolurieh, Hossein Baharvand and Nasser Aghdami

    Stem Cell Research & Therapy 2017 8:116

    Published on: 23 May 2017

  2. Research

    Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients

    Mesenchymal stem cells derived from the synovial membrane (synovial MSCs) are a candidate cell source for regenerative medicine of cartilage and menisci due to their high chondrogenic ability. Regenerative med...

    Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Shizuka Fujii, Koji Otabe, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta and Ichiro Sekiya

    Stem Cell Research & Therapy 2017 8:115

    Published on: 16 May 2017

  3. Research

    Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway

    Basic fibroblast growth factor (bFGF) plays an important role in promoting wound healing and reducing scar, but the possible molecular mechanisms are still unclear. Our previous studies have found that activat...

    Peng Wang, Bin Shu, Yingbin Xu, Jiayuan Zhu, Jian Liu, Ziheng Zhou, Lei Chen, Jingling Zhao, Xusheng Liu, Shaohai Qi, Kun Xiong and Julin Xie

    Stem Cell Research & Therapy 2017 8:114

    Published on: 16 May 2017

  4. Research

    Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats

    Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is one of the new therapeutic strategies for treating ischemic stroke. However, the relatively poor migratory capacity of BMSCs toward infa...

    Lin Li, Lisheng Chu, Yan Fang, Yan Yang, Tiebing Qu, Jianping Zhang, Yuanjun Yin and Jingjing Gu

    Stem Cell Research & Therapy 2017 8:112

    Published on: 12 May 2017

  5. Review

    Alzheimer’s disease, dementia, and stem cell therapy

    Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a conditio...

    Thomas Duncan and Michael Valenzuela

    Stem Cell Research & Therapy 2017 8:111

    Published on: 12 May 2017

  6. Review

    microRNAs: important regulators of stem cells

    Stem cells are undifferentiated cells and have multi-lineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cell...

    Na Li, Bo Long, Wei Han, Shumin Yuan and Kun Wang

    Stem Cell Research & Therapy 2017 8:110

    Published on: 11 May 2017

  7. Research

    Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

    Long-term ventricular pacing has deleterious effects and becomes more significant when cumulative percent ventricular pacing (Cum%VP) exceeds 40% of time. However, cellular disturbances and pathways by which p...

    Chang Cui, Le Geng, Jiaojiao Shi, Yue Zhu, Gang Yang, Zidun Wang, Jiaxian Wang and Minglong Chen

    Stem Cell Research & Therapy 2017 8:109

    Published on: 11 May 2017

  8. Research

    Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells

    The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells, such as nucleus pulpos...

    Kang Lu, Hai-yin Li, Kuang Yang, Jun-long Wu, Xiao-wei Cai, Yue Zhou and Chang-qing Li

    Stem Cell Research & Therapy 2017 8:108

    Published on: 10 May 2017

  9. Research

    Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model

    Interstitial cystitis (IC) is a chronic inflammation disorder mainly within the submucosal and muscular layers of the bladder. As the cause of IC remains unknown, no effective treatments are currently availabl...

    Jia Li, Hui Luo, Xingyou Dong, Qian Liu, Chao Wu, Teng Zhang, Xiaoyan Hu, Yuanyuan Zhang, Bo Song and Longkun Li

    Stem Cell Research & Therapy 2017 8:107

    Published on: 8 May 2017

  10. Research

    Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation

    Microcarrier cultures which are useful for producing large cell numbers can act as scaffolds to create stem cell-laden microcarrier constructs for cartilage tissue engineering. However, the critical attributes...

    Youshan Melissa Lin, Jialing Lee, Jessica Fang Yan Lim, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny and Steve Kah Weng Oh

    Stem Cell Research & Therapy 2017 8:93

    Published on: 8 May 2017

  11. Research

    Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films

    Satellite cells are quiescent resident muscle stem cells that present an important potential to regenerate damaged tissue. However, this potential is diminished once they are removed from their niche environme...

    Claire Monge, Nicholas DiStasio, Thomas Rossi, Muriel Sébastien, Hiroshi Sakai, Benoit Kalman, Thomas Boudou, Shahragim Tajbakhsh, Isabelle Marty, Anne Bigot, Vincent Mouly and Catherine Picart

    Stem Cell Research & Therapy 2017 8:104

    Published on: 2 May 2017

  12. Research

    Human adult mesangiogenic progenitor cells reveal an early angiogenic potential, which is lost after mesengenic differentiation

    Mesangiogenic progenitor cells (MPCs) have shown the ability to differentiate in-vitro toward mesenchymal stromal cells (MSCs) as well as angiogenic potential. MPCs have so far been described in detail as prog...

    Marina Montali, Francesca M. Panvini, Serena Barachini, Francesca Ronca, Vittoria Carnicelli, Stefano Mazzoni, Iacopo Petrini and Simone Pacini

    Stem Cell Research & Therapy 2017 8:106

    Published on: 2 May 2017

  13. Research

    The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response

    Radiation enteropathy is a common complication in patients with abdominopelvic cancer, but no treatment has yet been established. Stem cell therapy may be a viable therapeutic option because intestinal stem ce...

    Young-Min Han, Jong-Min Park, Yong Soo Choi, Hee Jin, Yun-Sil Lee, Na-Young Han, Hookeun Lee and Ki Baik Hahm

    Stem Cell Research & Therapy 2017 8:105

    Published on: 2 May 2017

  14. Research

    Human mesenchymal stem cells maintain their phenotype, multipotentiality, and genetic stability when cultured using a defined xeno-free human plasma fraction

    Mesenchymal stem cells (MSCs) show promising characteristics for their use in advanced therapy medicinal products. However, there are some unresolved concerns, such as the use of animal components for their ex...

    Arantxa Blázquez-Prunera, José María Díez, Rodrigo Gajardo and Salvador Grancha

    Stem Cell Research & Therapy 2017 8:103

    Published on: 27 April 2017

  15. Research

    Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acid

    Mesenchymal stem cells (MSCs) have entered the clinic as an Advanced Therapy Medicinal Product and are currently evaluated in a wide range of studies for tissue regeneration or in autoimmune disorders. Various...

    Madeleine C. Killer, Philipp Nold, Katharina Henkenius, Lea Fritz, Tabea Riedlinger, Christina Barckhausen, Miriam Frech, Holger Hackstein, Andreas Neubauer and Cornelia Brendel

    Stem Cell Research & Therapy 2017 8:100

    Published on: 26 April 2017

  16. Research

    Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration

    Three-dimensional cultured clumps of a mesenchymal stem cell (MSC)/extracellular matrix (ECM) complex (C-MSC) consists of cells and self-produced ECM. C-MSC can regulate the cellular function in vitro and indu...

    Kei Takeshita, Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita and Hidemi Kurihara

    Stem Cell Research & Therapy 2017 8:101

    Published on: 26 April 2017

  17. Research

    Adipose-derived mesenchymal stem cells modulate CD14++CD16+ expression on monocytes from sepsis patients in vitro via prostaglandin E2

    Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis. CD16+ monocytes are proinflammatory and abundant in inflammatory conditions such...

    Guanguan Qiu, Guoping Zheng, Menghua Ge, Lanfang Huang, Haijiang Tong, Ping Chen, Dengming Lai, Yaoqin Hu, Baoli Cheng, Qiang Shu and Jianguo Xu

    Stem Cell Research & Therapy 2017 8:97

    Published on: 26 April 2017

  18. Research

    Label retention and stem cell marker expression in the developing and adult prostate identifies basal and luminal epithelial stem cell subpopulations

    Prostate cancer is the second most frequent cancer among males worldwide, and most patients with metastatic disease eventually develop therapy-resistant disease. Recent research has suggested the existence of ...

    Jens Adam Ceder, Tilly Wilhelmina Aalders and Jack Antonius Schalken

    Stem Cell Research & Therapy 2017 8:95

    Published on: 26 April 2017

  19. Research

    Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-β/catenin signaling pathway

    Ring finger protein 43 (RNF43) is a member of the transmembrane E3 ubiquitin ligase family that was originally found in stem cells and plays important roles in tumor formation and progression. Our previous stu...

    Yunhe Gao, Aizhen Cai, Hongqing Xi, Jiyang Li, Wei Xu, Yanmei Zhang, Kecheng Zhang, Jianxin Cui, Xiaosong Wu, Bo Wei and Lin Chen

    Stem Cell Research & Therapy 2017 8:98

    Published on: 26 April 2017

  20. Research

    Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton’s jelly and bone marrow-derived mesenchymal stem cells

    In view of the current interest in exploring the clinical use of mesenchymal stem cells (MSCs) from different sources, we performed a side-by-side comparison of the biological properties of MSCs isolated from ...

    Aristea K. Batsali, Charalampos Pontikoglou, Dimitrios Koutroulakis, Konstantia I. Pavlaki, Athina Damianaki, Irene Mavroudi, Kalliopi Alpantaki, Elisavet Kouvidi, George Kontakis and Helen A. Papadaki

    Stem Cell Research & Therapy 2017 8:102

    Published on: 26 April 2017

  21. Research

    The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm

    Human mesenchymal stem cells (MSCs) possess well-known reparative abilities, but any defect of the immunomodulatory activity and/or the differentiation process may determine the development of human diseases, ...

    Carmen Ciavarella, Enrico Gallitto, Francesca Ricci, Marina Buzzi, Andrea Stella and Gianandrea Pasquinelli

    Stem Cell Research & Therapy 2017 8:99

    Published on: 26 April 2017

  22. Research

    The effect of adipose tissue-derived stem cells in a middle cerebral artery occlusion stroke model depends on their engraftment rate

    In the field of experimental stem cell therapy, intra-arterial (IA) delivery yields the best results concerning, for example, migrated cell number at the targeted site. However, IA application also appears to ...

    Saskia Grudzenski, Sebastian Baier, Anne Ebert, Pim Pullens, Andreas Lemke, Karen Bieback, Rick M. Dijkhuizen, Lothar R. Schad, Angelika Alonso, Michael G. Hennerici and Marc Fatar

    Stem Cell Research & Therapy 2017 8:96

    Published on: 26 April 2017

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