Figure 5

Body weight, physiological effects, and life span. (A) After post-natal day (PND) 23, the body weight of oligodendrocyte progenitor cell (OPC)-injected twitcher mice (GALC^twi/twi) and saline-injected twitcher mice (GALC^twi/twi) decreased compared to the wild type. There was no statistically significant difference in the body weight between OPCs injected twitcher mice (GALC^twi/twi) and saline injected twitcher mice (P >0.05). (B) The stride length of the wild type was 6.13 ± 0.15 cm at PND 41. At PND 26, stride length of OPC-injected twitcher mice (GALC^twi/twi) and saline-injected twitcher mice (GALC^twi/twi) reached the maximum value, which shortened as the disease progressed. The differences were not statistically significant between the two groups (P >0.05). (C, D) Twitcher mice (GALC^twi/+) never twitch at all. OPC-injected twitcher mice (GALC^twi/twi) and saline-injected twitcher mice (GALC^twi/twi) had severe twitching at PND 26, and there were no significant differences in the scores of twitching frequency and severity (P >0.05). (E) A Kaplan-Meier survival analysis using the log-rank test revealed that OPC transplanted mice and control homozygous twitcher mice did not survive beyond 40 days of age. There was no significant difference in life span of the twitcher mice between those that were transplanted with OPCs and saline injection (P >0.01). GALC, galactocerebrosidase.