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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Figure 5

Activation kinetics of slowly activating delayed rectifier potassium channel measured in human induced pluripotent stem cell cardiomyocytes. (A) Activation kinetics of slowly activating delayed rectifier potassium channel (IKs) measured in control and patient human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs). (B) Activation of IKs measured in family control hiPSC-CMs prior to and post ML277 treatment. (C) Activation of IKs measured in patient hiPSC-CMs prior to and post ML277 treatment. The half-maximal activation voltage (V(1/2)) was calculated and presented in the inserted tables. *P <0.05, versus control or baseline. LQT1, type 1 long QT syndrome.

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Stem Cell Research & Therapy

ISSN: 1757-6512