Figure 2From: Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities Extensive mouse hepatocyte proliferation after administration of diphtheria toxin. Immunofluorescent staining for cell proliferation markers Ki67 (A) and BrdU (B) in liver tissues from 8-week-old Alb-TRECK/SCID mice without and with diphtheria toxin (DT) treatment. DT-treated mouse liver with serum aspartate aminotransferase activity of 12,000 IU/L was sampled at 48 hours. At 2 hours before sampling, BrdU (50 mg/kg) was administered intraperitoneally. Experiments were performed with five mice/group, and representative images are shown. Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI). Scale bars = 100 μm.Back to article page