Figure 4From: Hematopoiesis: from start to immune reconstitution potential Hematopoietic stem cell maintenance. Purified long-term hematopoietic stem cells (HSCs) from adult animals can reconstitute immune-deficient hosts in vivo. However, hematopoietic cells generated in vitro cannot achieve the same functional outcome. The self-renewal capacity can be induced with the expression of homeobox B4 (HoxB4) ectopically in developing embryonic stem cells, indicating that this potential is present although the trigger is unknown.Back to article page