Figure 6

Secretions of the anti-inflammatory and the anti-angiogenic factors G-CSF, MIG, and angiostatin, and TIMP-1 and TIMP-2, following co-culture of ASCs or ST2 cells with Gr1⁺, F4/80⁺, or CD11c⁺ cells. (A) Secretions of G-CSF and MIG. (B) Secretion of angiostatin. (C) Secretions of TIMP-1 and TIMP-2. Comparisons are made with monocultures (non). Data are presented as means ± standard deviation. *P < 0.0001, **P < 0.0005, ***P < 0.05, versus monocultured cells; Dunnett’s test (n = 5). ASC, adipose tissue-derived stromal cell; G-CSF, granulocyte-colony stimulating factor; MIG, monokine induced by interferon γ; N.D., not detected; ST2 cell, bone marrow-derived stromal cell; TIMP, tissue inhibitors of metalloproteinase.