Figure 9
Effects of implantation of DFAT cells on mRNA expression of cytokines in renal cortex of mAb 1-22-3-injected rats. Wistar rats were nephrectomized and injected without mAb 1-22-3 (Control) or with 0.5 mg mAb 1-22-3 through the tail vein seven days after nephrectomy. Thirty-five days after nephrectomy, saline (Saline) or 106 DFAT cells were injected through the renal artery (DFAT ia) or tail vein (DFAT iv). Sixty-three days after nephrectomy, the left kidney was removed. Real-time quantitative PCR was performed for expression of IL-6 (A), IL-10 (B), IL-12β (C) and TGF-β1 (D) mRNAs. Data are the mean ± SEM (n = 6). *P <0.05 and **P <0.01 in the indicated columns. DFAT, dedifferentiated fat; mAb, monoclonal antibody; SEM, standard error of the mean; TGF- β1, transforming growth factor- β1.