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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis

Fig. 4

Mitochondrial dysfunction and ROS overproduction in 3T3L1-PG cells. a Measurement of the mitochondrial complex activity in digitonin-permeabilized cells demonstrates significant changes in complexes I, IV and V. b PG-3T3L1 cells show a significant increase in the mitochondrial ROS production, as revealed by MitoSox™ analysis. c Measurement of the rate of oxygen consumption (OCR) indicates that PG-3T3L1 cells have an increased mitochondrial basal activity. *Significance (p <0.05) using the Kruskal–Wallis non-parametric test. ***Significance (p <0.001) using the Kruskal–Wallis non-parametric test. Scale bar = 10 μm. CS citrate synthase, PG progerin

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Stem Cell Research & Therapy

ISSN: 1757-6512