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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Urokinase-type plasminogen activator receptor interaction with β1 integrin is required for platelet-derived growth factor-AB-induced human mesenchymal stem/stromal cell migration

Fig. 6

ASC migration is mediated by uPAR. a Scratch test assay was performed on ASC isolated from three different donors transfected with either si Neg or si uPAR and grown on type I dermal collagen in serum-free control medium or PDGF-AB-supplemented medium. Scale bars: 200 μm. b Quantification of ASC migration. Results expressed as percentages of wound closure at T = 22 h compared with T = 0 for each condition. Mean of three independent experiments ± SEM is represented (one donor per experiment), each performed in triplicate. *P <0.05. ASC adipose stem/stromal cells, si Neg nontargeting small interfering RNA, si uPAR uPAR-targeted small interfering RNA, PDGF-AB platelet-derived growth factor AB

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Stem Cell Research & Therapy

ISSN: 1757-6512