Fig. 2
Treatment with adCD-MSCs protects against DSS-induced colitis. Mice received 1.5 % of DSS with their drinking water for 9 days. At days +7, +9, and +11 from DSS induction, mice are treated by enema with adCD-MSCs (1 × 106 cells/mice/time) or phosphate saline buffer (PBS) alone. (Top) Schematic of the experiment. The evolution of colitis is monitored by body weight change expressed as a percentage of the initial body weight at day 0 (100 %). CTR, healthy control mice (dotted black line); DSS+adCD-MSCs, DSS-treated mice which received adCD-MSCs (blue line); DSS+PBS, DSS-treated mice which received PBS alone (red line). Data expressed as mean ± standard error of the mean (SEM). n = 4 mice per group. CTR vs. DSS+PBS, ****p <0.0001; DSS+adCD-MSCs vs. DSS+PBS, **p <0.01. adCD-MSC mesenchymal stromal cell isolated from adipose tissue of Crohn’s disease patients, DSS dextran sulfate sodium