Skip to main content

Table 1 Mineral density and histomorphometry of tibias in the seven groups of rats

From: Co-administration of aspirin and allogeneic adipose-derived stromal cells attenuates bone loss in ovariectomized rats through the anti-inflammatory and chemotactic abilities of aspirin

Groups

Sham

OVX

ZOL

ASC CM

ASC

ASP

ASC + ASP

BMD (g/cm3)

1.791 ± 0.048

1.445 ± 0.031 a

1.969 ± 0.069 a,b

1.497 ± 0.031 a,b,c

1.457 ± 0.045 a,c,d

1.466 ± 0.034 a,c

1.470 ± 0.024 a,c

BV/TV (%)

44.009 ± 2.432

23.676 ± 2.848 a

87.026 ± 2.388 a,b

29.216 ± 2.435 a,b,c

30.202 ± 4.569 a,b,c

29.378 ± 3.394 a,b,c

34.521 ± 1.965 a,b,c,d,e,f

BS/BV (mm−1)

33.857 ± 2.247

37.474 ± 1.611a

12.362 ± 2.142 a,b

35.788 ± 1.108 c

33.214 ± 2.372 b,c,d

33.784 ± 2.210 b,c,d

32.162 ± 1.642 b,c,d

Tb.Th (mm)

0.059 ± 0.003

0.053 ± 0.002 a

0.156 ± 0.003 a,b

0.056 ± 0.002 a,c

0.060 ± 0.004 b,c,d

0.059 ± 0.004 b,c,d

0.062 ± 0.003 b,c,d

Tb.N (mm−1)

7.376 ± 0.204

4.427 ± 0.473 a

8.008 ± 0.252 a,b

5.223 ± 0.400 a,b,c

4.979 ± 0.540 a,b,c

4.934 ± 0.359 a,b,c

5.551 ± 0.410 a,b,c,e,f

Tb.Sp (mm)

0.077 ± 0.008

0.174 ± 0.022 a

0.026 ± 0.007 a,b

0.137 ± 0.015 a,b,c

0.143 ± 0.025 a,b,c

0.144 ± 0.018 a,b,c

0.119 ± 0.012 a,b,c,e,f

  1. Parameters of bone mineral density (BMD) and microarchitecture (BV/TV, BS/BV, Tb.Th, Tb.N, Tb.Sp) were measured in the trabecular bone of the proximal tibia (1–2 mm distal to the proximal physis) using micro-CT. Data are the mean ± SD, n = 70
  2. OVX ovariectomized, ZOL zoledronate, ASC adipose-derived stromal cells, CM conditioned medium, ASP aspirin, BV/TV bone volume/total volume, BS/BV bone surface area/bone volume, Tb.Th trabecular thickness, Tb.N trabecular number, Tb.Sp trabecular separation
  3. a p < 0.05 vs. Sham, b p < 0.05 vs. OVX, c p < 0.05 vs. ZOL, d p < 0.05 vs. ASC CM, e p < 0.05 vs. ASC, f p < 0.05 vs. ASP