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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

Fig. 7

Noggin rescued OPA1 +/−-iPSC differentiation into RGCs confirmed by IF. Mature EBs were cultured with 100 ng/mL Noggin to obtain putative RGCs. Cells were fixed with 4 % PFA on day 31. a TUJ-1 (green) and BRN3a (red) staining are shown. b TUJ-1 (green) and ISLET1 (red) staining are shown. Scale bars = 50 μM in panel (a) and 100 μM in panel (b)

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Stem Cell Research & Therapy

ISSN: 1757-6512