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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: microRNA-206 is involved in survival of hypoxia preconditioned mesenchymal stem cells through targeting Pim-1 kinase

Fig. 2

Pim-1 is a putative target of miR-206 in MSCs. a Binding motif (2136–2142) of miR-206 on Pim-1 3′-UTR (2041–2759). b Percentages of miR-206 expression in MSCs under hypoxia vs normoxia (n = 3). *P < 0.05 vs normoxia. c Construction of luciferase construct. d Relative Rluc/Luc ratio (n = 3). *P < 0.05 vs Pim-1-WT + NC. e Expression of miR-206 in MSCs after transfection of mimics and inhibitors (n = 6). *P < 0.05 vs non-trans, NC, and inhibitor; # P < 0.05 vs non-trans and NC. f Expression of Pim-1 in MSCs after transfection of miR-206 mimics and inhibitors (n = 6). *P < 0.05 vs non-trans; ### P < 0.001 vs non-trans, NC negative control and mimics. miR-206 microRNA-206, MSC mesenchymal stem cell, UTR untranslated region, WT wild type

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Stem Cell Research & Therapy

ISSN: 1757-6512