Fig. 4

Characteristics of MSCs from MRONJ mice treated with MSCs. a Experimental protocol. Wild-type C57BL/6 J mice received both Dex and Zol administered intravenously for 2 weeks (n = 5 × 2 groups). MSCs were isolated from MRONJ model mice treated with c-MSCs or d-MSCs a day after tooth extraction (M-cMSC and M-dMSC(+)). b MSC abnormalities in MRONJ were reversed by c-MSCs but not d-MSCs. CFU-F colony-forming unit-fibroblast, c-MSC control MSC, d days, d-MSC diseased MSC, EdU 5-ethynyl-2′-deoxyuridine, i.p. intraperitoneal, i.v. intravenous, MRONJ medication-related osteonecrosis of the jaw, MSC mesenchymal stem cell