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Table 1 The comparison of hESC-CMs with hiPSC-CMs

From: Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes

Drug

hESC-CMs

hiPSC-CMs

CI (μmol•L-1)

IC50/EC50 (μmol•L-1)

CI (μmol•L-1)

IC50/EC50 (μmol•L-1)

E-4031

0.01↑

0.02

0.1↓

0.04

Isoprenaline

0.1↓

0.04

1↓

0.03

Quinidine

100↓

2.18

100↓

13.97

Haloperidol

NO

0.14

10↓

5.17

  1. CI cell index, hESC-CMs human embryonic stem cells-derived cardiomyocytes, hiPSC-CMs human induced pluripotent stem cells-derived cardiomyocytes