From: Cardiosphere-derived cells do not improve cardiac function in rats with cardiac failure
Experimental group | |||||
---|---|---|---|---|---|
Parameter | Time (days) | Sham (n = 8) | Placebo (n = 9) | hCDC (n = 11) | rCDC (n = 10) |
Ejection fraction (%) | –1 | 76.85 ± 4.24 | 75.50 ± 1.48 | 79.83 ± 5.34 | 72.97 ± 3.69 |
59 | 70.72 ± 2.08 | 32.88 ± 6.28* | 31.48 ± 7.26* | 30.39 ± 6.97* | |
90 | 69.33 ± 5.45 | 34.49 ± 9.48* | 31.26 ± 7.66* | 29.56 ± 7.59* | |
120 | 69.44 ± 5.36 | 34.62 ± 11.08* | 30.89 ± 6.39* | 28.58 ± 7.68* | |
End-diastolic volume (μl) | –1 | 358.8 ± 68.61 | 383.7 ± 80.47 | 323.2 ± 39.71 | 357.7 ± 65.29 |
59 | 424.4 ± 97.15 | 643.1 ± 98.04* | 712.3 ± 137.9* | 656.8 ± 213.1* | |
90 | 438.7 ± 110.40 | 730.6 ± 172.90* | 833.3 ± 234.3* | 736.3 ± 259.8* | |
120 | 467.7 ± 108.2 | 736.20 ± 161.6* | 830 ± 243.9* | 840.2 ± 313.4* | |
End-systolic volume (μl) | –1 | 80.91 ± 22.78 | 93.20 ± 25.63 | 69.52 ± 16.13 | 96.06 ± 18.68 |
59 | 121.4 ± 28.45 | 382.4 ± 105.2* | 502 ± 135.8* | 464.40 ± 179.3* | |
90 | 137.5 ± 50.67 | 488.80 ± 160.5* | 609.2 ± 244.8* | 525 ± 212.6* | |
120 | 142 ± 34.97 | 492.5 ± 163.6* | 551 ± 214.9* | 591.40 ± 271.3* | |
Fractional area change (%) | –1 | 71.38 ± 11.53 | 67.38 ± 9.06 | 73.75 ± 8.34 | 66.05 ± 8.87 |
59 | 66.58 ± 7.23 | 30.22 ± 10.12* | 25.15 ± 11.40* | 24.90 ± 10.79* | |
90 | 63.95 ± 19.47 | 25.70 ± 9.56* | 20.78 ± 10.16* | 25.85 ± 8.36* | |
120 | 57.33 ± 11.30 | 27.71 ± 20.11* | 29.65 ± 11.46* | 25.47 ± 9.69* |