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Table 1 Biochemical parameters of SDFTs treated with AT-MSCs suspended in autologous inactivated serum (AT-MSC-serum) and autologous inactivated serum alone (serum) and macroscopically normal tendon tissue (normal) from the same tendons 22 weeks after treatment

From: Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial

 

Group

Parameter

AT-MSC-serum (n = 9)

Serum (n = 9)

Normal (n = 18)

DNA (μg/mg dwt)

3.91 ± 0.96a

4.24 ± 1.31a

1.99 ± 0.30b

GAG (μg/mg dwt)

21.38 ± 11.44a

26.80 ± 10.26a

6.47 ± 1.16b

Hyp (mg/mg dwt)

0.067 ± 0.001a

0.062 ± 0.012a

0.083 ± 0.009b

Total collagen (mg/mg dwt)

0.510 ± 0.076a

0.469 ± 0.093a

0.635 ± 0.071b

HP (mol/mol col)

0.196 ± 0.025ab

0.184 ± 0.026b

0.238 ± 0.040a

LP (mol/mol col)

0.016 ± 0.005a

0.017 ± 0.007a

0.013 ± 0.005a

HLys (mol/mol col)

6.90 ± 1.76a

7.39 ± 2.37a

7.38 ± 1.96a

  1. Values presented as mean ± standard deviation
  2. col collagen, dwt dry weight, GAG glycosaminoglycans, HLys Hydroxylysine, HP hydroxylysylpyridinoline, Hyp Hydroxyproline, LP lysylpyridinoline, AT-MSC adipose-derived mesenchymal stromal cell, SDFT superficial digital flexor tendon
  3. a,bDifferent superscript letters indicate significant differences (p < 0.05) between treatment groups