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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells

Fig. 7

Efficacy of intravenous administration of pIPCs and IPCs at weeks 9 and 10 in preventing type 1 diabetes in nonobese diabetic (NOD) mice. a Blood glucose levels of control mice given only PBS; animals with blood glucose levels above 250 mg/dl twice consecutively were considered diabetic. The combined results of all the controls studied (n = 28) in the different experiments. b Blood glucose levels of mice given precursors to insulin-producing cells (pIPCs) (passage 11, 12, and 13) grown in high-glucose IMDM media (combined results of six experiments, n = 24). c Blood glucose levels of mice given differentiated insulin-producing cells (IPCs) at 10 weeks of age (combined result of two experiments, n = 10). d Bar graph showing percent of nondiabetic mice after treatment with PBS, pIPCs, and IPCs: 38.75 ± 1.99% (mean ± SEM) of NOD mice (n = 28) in the control group remained nondiabetic, 76.67 ± 10.54% NOD mice (n = 24) receiving pIPCs remained nondiabetic, and 60.0 ± 0% of NOD mice (n = 10) receiving differentiated IPCs remained nondiabetic

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Stem Cell Research & Therapy

ISSN: 1757-6512