Fig. 3

An autocrine signaling circuit of GDF7 in hepatocytes and cholangiocytes occurs in liver fibrosis. (A), UMAP plot of cells isolated from human liver tissues, showing different expression level of GDF7 from 5 databases that were identified. (B), Relative abundances of GDF7, BMPR2, BMPR1A and BMPR1B read counts in single cells were normalized to transcripts in different liver cell types classed by cell type-specific markers. Cholangiocyte types were circled with red line, endothelial types were circled with green line; HSC and fibroblast were circled with blue line, hepatocyte types were circled with yellow line, immune cells were circled with purple line