Table 4 Changes in study outcome measures according to echocardiography, mean ± SD and median (Q3–Q1)

EF baseline

35.73 ± 3.59

36 (38–32)

34.75 ± 1.97

34 (37–33.3)

33.85 ± 1.67^a

33 (36–32.3)

EF final

44.27 ± 8.65

43 (49–39)

50 ± 10.21

49 (61–40)

53 ± 12.11^a

52 (64–43)

EF change

8.53 ± 9.39

8 (15–3)

15.25 ± 8.35

15 (24–6.8)

19.25 ± 9.12^a

19 (28–10.8)

LVEDD baseline

50.92 ± 6.16

51 (56–44.8)

54.5 ± 5.87

55 (60.5–48)

55.4 ± 7.65^a

56.5 (62.5–49)

LVEDD final

55.8 ± 5.23

57 (59–51)

57.25 ± 11.27

52.5 (70.3–49)

54.25 ± 10.67^a

49.5 (67.3–46)

LVEDD change

5.46 ± 7.37

6 (9.5–(− 0.3))

2.75 ± 10.96

3.5 (14–(− 9.3))

− 1.15 ± 11.59

0 (12–(− 14))

LVESD baseline

36.92 ± 6.58

37 (41.3–31.5)

36.75 ± 6.7

37.5 (43.5–29.3)

39.65 ± 6.96

43 (45–31.5)

LVESD final

42.53 ± 8.32

38 (47–37)

39 ± 17.74

34 (60–23)

35 ± 16.94

30 (56–19)

LVESD change

6.62 ± 7.9

2 (10–1.8)

2.25 ± 14.83

1.5 (18.8–(− 13.5))

− 4.65 ± 14.55^a

− 11 (12.5–(− 19.3))

LVEDV baseline

98.08 ± 23.55

101.5 (116.3–78.5)

118.25 ± 22.61

123.5 (139–92.3)

123.25 ± 21.91^a

128.5 (144–128.5)

LVEDV final

101.33 ± 23.94 103 (125–78)

121.75 ± 50.33 114 (177.3–74)

116.75 ± 48.93

109 (172.3–69)

LVEDV change

4.58 ± 21.15

0.5 (28.8–(− 15.5))

3.5 ± 3.23

1 (51.3–(− 41.75))

− 6.5 ± 4.32

− 9 (41.3–(− 51.8))

LVESV baseline

63.25 ± 14.54

65.5 (73.5–49.7)

77.31 ± 15.91

79.4 (92.8–59.8)

81.81 ± 16.18^a

83.8 (97.6–64)

LVESV final

56.8 ± 16.49

62.1 (69–40.3)

65.59 ± 38.28

58.1 (108.2–30.4)

59.59 ± 36.28

52.3 (100–26.4)

LVESV change

− 5.68 ± 16.62

− 5.1 (4.6–(− 20.1))

− 11.72 ± 5.18

− 16.4 (24–(− 42.7))

− 22.22 ± 9.26

− 26.7 (11.2–(− 51.11))

GLS baseline

− 9.84 ± 2.6

− 9.5 (− 8.6–(− 11))

− 9.28 ± 2.34

− 10.1 (− 6.5–(− 11.2))

− 8.28 ± 1.95

− 9.1 (− 5.5–(10.2))

GLS final

− 14.13 ± 2.77

− 14.2 (− 13–(− 16.5))

− 16.05 ± 3.85

− 16.5 (− 11.7–(− 19.9))

− 18.05 ± 3.75^a

− 18.6 (− 13.7–(− 21.9))

GLS change

− 3.92 ± 2.35

− 3.7 (− 2.9–(− 4.81))

− 6.77 ± 3.05^a

− 7.4 (− 3.3–(− 9.6))

− 9.77 ± 3.65^a

− 10.4 (− .3–(− 12.6))