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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury

Fig. 3

The impact of ESC–MSC-EVs on skeletal muscle fiber regeneration, tissue fibrosis, and muscle function in ACS rat. A Representative images (200×) of HE staining of TA muscle sections at 7 d after ACS (myofibers that contained a central nucleus were used as the definition for regenerating myofibers). Scale bar: 100 μm. B Quantitative analysis pertaining to the numerical quantity of rejuvenating myofibers (n = 6). C Quantitative appraisal concerning the width of regenerating myofibers (n = 6). D Representative images (200x) of Masson staining of TA muscle sections at 14 d after ACS. Scale bar: 100 μm. E Quantitative analysis of the fibrotic area of skeletal muscle tissue sections at 14 d after ACS (n = 6). F Grip strength at 14 d after ACS (n = 6). G Hanging time at 14 d after ACS (n = 6). Data are presented as the mean ± SD. *P < 0.05 versus Sham + vehicle group and #P < 0.05 versus ACS + vehicle group

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Stem Cell Research & Therapy

ISSN: 1757-6512