Table 2 Small molecules to enhance direct cardiac differentiation
From: Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species
Name | Characteristics | Refs. |
|---|---|---|
VPA (Selleck, S3944) | Histone deacetylase (HDAC) inhibitor, enhanced induction of hiPSC | [22] |
mTORi (Selleck, S1039) | Cell proliferation, survival and transcription regulation, enhanced induction of hiPSC | [25] |
VitC (Sigma, A4544) | Antioxidant and cofactor for epigenetic modifiers, involved in cardiac differentiation from hiPSC | [19] |
5-AZA (Selleck, S1782) | DNA methylation inhibitor, involved in cardiac differentiation from human embryonic stem cells | [29] |
P53i (Selleck, S2929) | Transcription regulation, DNA damage and repair regulation, enhanced induction of hiPSC | [23] |
SAHA (Selleck, S1047) | Histone deacetylase (HDAC) inhibitor, enhanced induction of hiPSC | [22] |
CHIR-99021 (Selleck, S1263) | GSK-3 inhibitor, involved in cardiac differentiation from hiPSC | [24] |