Fig. 1

Establishment of apical periodontitis models in dogs. A–C Model A. D–F Model B. A, D Periapical lesions captured by cone-beam computed tomography (CBCT). B, E Bacterial colonies in brain heart infusion agar 48 h after plating. C, F Correlations of periapical lesion volume to bacterial numbers before root canal treatment (C: R = 0.645, F: R = 0.558)