Fig. 7

Cell interaction analysis. a Heatmap of the number of ligand–receptor pairs possessed by each pair of cells (horizontal is ligand cell subgroup, vertical is receptor cell subgroup, and different colors are used to represent the number of ligand–receptor pairs possessed by each pair of cells. The smaller the number of ligand–receptor pairs possessed by this pair of cells, the bluer the color of the cell, and the more ligand–receptor pairs possessed by this pair, the redder the color of the cell). b Cell interaction network diagram, bubbles represent cell subsets, and the size of bubbles is determined by the number of significantly enriched receptor pairs between subsets and all interacting subsets. The larger the bubbles are, the larger the total number, indicating a stronger association of subsets in the population. The number of significantly enriched receptor pairs between subgroups is represented by a line. The number of significantly enriched receptor pairs between subgroups determines the thickness of the line. The thicker the line is, the greater the number of significantly enriched receptor pairs between subgroups, and the stronger the communication relationship between subgroups. c Cell interaction network diagram of the aging group. d Cell interaction network diagram of the treatment group