Efficacy and safety of stem cell therapy for Crohn’s disease: a meta-analysis of randomized controlled trials

Table 3 Summarized certainty of evidence using the GRADE system

Outcome	Quality assessment							Absolute effect OR (95% CI)	Quality
Outcome	No. of studies	Design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Absolute effect OR (95% CI)	Quality
CR	12	RCTs	Serious	No serious inconsistency	No serious indirectness	No serious imprecision	None	2.08 (1.39–3.12)	⊕ ⊕ ⊕ Ο MODERATE
SAE	9	RCTs	Serious	No serious inconsistency	No serious indirectness	No serious imprecision	None	0.70 (0.37–1.33)	⊕ ⊕ ⊕ Ο MODERATE

GRADE, Grading of Recommendations, Assessment, Development and Evaluation; CR, clinical remission; SAE, severe adverse events; RCT, randomized controlled trials; OR, odds ratio; CI, confidence interval;

ISSN: 1757-6512