Fig. 1

Signaling pathways involve in the viability of MSCs after treated with nature compounds. A NC treatment can inhibit pro-inflammatory NFκB pathway. B ERK-MAPK pathway is involved in the inhibition of pro-inflammatory cytokines. C Sal B prevents cells from apoptosis stimulated by H2O2 through the suppression of the ERK-MAPK pathway. D Inhibition of either ERK/MAPK or PI3K/AKT pathway leads to a significant decline in cell viability. E Sirt1 pathway significantly mediates the regulation of resveratrol on MSCs differentiation. F Resveratrol protects cells through negatively regulating the expression of inflammatory cytokines by autophagy. G mTOR signaling regulated by NC treatment is one of the most important metabolic checkpoints controlling cell death and the cross talk between apoptosis and autophagy. H Cross talk between ERK and Wnt pathways via resveratrol treatment regulates immunomodulation of MSCs. I miRNAs are essential for the protective effects on BMSCs. J Resveratrol ameliorates MSC viability through suppression of ER stress. This figure is created with BioRender.com