Fig. 2

Signaling pathways involve in the differentiation of MSCs after treated with nature compounds. A NFκB and Wnt signaling pathways are involved in the differentiation of MSCs. B YAP expression and nuclear translocation mediated by resveratrol directly enhances osteogenesis of MSCs. C Astragaloside treatment ameliorates osteoporosis through re-balancing the osteogenesis and adipogenesis. D Osthole-mediated histone modifications rescue bone loss phenotypes in periodontitis. E EGCG treatment ameliorates hypoxia-induced bone loss via activation of osteogenic genes. This figure is created with BioRender.com