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Table 1 Urine albumin and kidney weight parameters at the end-points of two in vivo experiments

From: Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy

Parameters

10 weeks

18 weeks

Non-DM1

DM + NS1

DM + MSC1

Non-DM2

DM + NS2

DM + MSC2

UMA (mg/L)

3.580 ± 0.505

6.520 ± 1.023

5.460 ± 1.103

3.872 ± 0.778

4.961 ± 1.375

2.036 ± 0.438

Ucr (mmol/L)

5.152 ± 0.837

1.028 ± 0.178*

1.270 ± 0.267*

2.707 ± 0.171

0.499 ± 0.081*

0.277 ± 0.027*

uACR (mg/g)

8.080 ± 0.836

74.520 ± 7.334*

47.740 ± 3.616*#

12.860 ± 1.994

88.402 ± 3.240*

70.340 ± 17.470*#

KW (g)

0.200 ± 0.009

0.156 ± 0.007*

0.160 ± 0.006*

0.178 ± 0.007

0.147 ± 0.003*

0.165 ± 0.011

KI (mg/g)

6.189 ± 0.143

7.408 ± 0.217*

7.013 ± 0.240*

6.456 ± 0.196

8.007 ± 0.429*

8.045 ± 0.311*

  1. Non-DM1 = Nondiabetic mice analyzed 10 weeks after initiation of the experiments; DM + NS1 = Diabetic mice injected with normal saline and analyzed 10 weeks after induction of diabetes; DM + MSC1: Diabetic mice injected with hUC-MSCs and analyzed 10 weeks after induction of diabetes; Non-DM2 = Nondiabetic mice analyzed 18 weeks after initiation of the experiments; DM + NS2 = Diabetic mice injected with normal saline and analyzed 18 weeks after induction of diabetes; DM + MSC2: Diabetic mice injected with hUC-MSCs and analyzed 18 weeks after induction of diabetes; UMA = Urine microalbumin concentration; Ucr = Urine creatinine concentration; uACR = Urine albumin creatinine ratio; KW = Kidney weight; KI, Kidney index. Data are presented as the mean ± SEM
  2. * = p < 0.05 versus Non-DM group, # = p < 0.05 versus DM + NS group