Fig. 5
TC14012 contributes UC-MSCs to restoring CXCR7 expression and suppressing inflammation in the mice model of CCl4-induced acute liver injury. The CCl4-induced liver fibrotic mice were treated with UC-MSCs with or without TC14012 pretreatment. a and b The CXCR7 expression and quantitative analysis in liver were performed by immunofluorescent staining, each group n = 6 mice. Scale bar: 100 μm. c and d The inflammatory response in liver were observed by H&E staining (c) and immunofluorescent staining of IL-1β (d). Scale bar: 100 μm. e The quantitative analysis of immunofluorescent staining of IL-1β in liver, each group n = 6 mice. The data were presented as the mean ± SD. One-way ANOVA and Student’s t-test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001