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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: TC14012 enhances the anti-fibrosis effects of UC-MSCs on the liver by reducing collagen accumulation and ameliorating inflammation

Fig. 7

Schematic diagram showing how TC14012 enhances the therapeutic potential of UC-MSCs in liver fibrosis. TC14012 treatment promotes the migration and immunosuppressive function of UC-MSCs. In addition, the increased CXCR7 expression in TC14012 pretreated UC-MSCs could regulate CXCR7 expression in LSEC through paracrine functions. TC14012-pretreated UC-MSCs show better anti-fibrotic effects than UC-MSCs. Various pathological factors stimulate HSCs activation and inflammatory cell infiltration leading to excessive extracellular matrix deposition (especially collagen fibril) and liver damage ultimately contributing to liver fibrosis. TC14012-pretreated UC-MSCs exhibit better anti-fibrotic efficacy compared to UC-MSCs by reducing HSCs activation, alleviating inflammation, and restoring CXCR7 expression

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Stem Cell Research & Therapy

ISSN: 1757-6512