Fig. 4
From: PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties
Effect of PLOD2 on chondrocyte gene expression on OA-like chondrocytes. A Workflow for the generation of OA-like chondrocytes by incubation with IL1β and their co-culture. B RT-qPCR analysis of different chondrocyte and inflammatory markers in control (NT) and OA-like chondrocytes (IL1β) co-cultured or not with MRL MSC and BL6 MSC (n = 19). C RT-qPCR analysis of different chondrocyte and inflammatory markers in control (NT) and OA-like chondrocytes (IL1β) co-cultured or not with MRL MSCsiCTL and MSC MRLsiPLOD2 (n = 19). D RT-qPCR analysis of different chondrocyte and inflammatory markers in control (NT) and OA-like chondrocytes (IL1β) co-cultured or not with MSC BL6 and BL6 MSC+CM PLOD2 (n = 6). Error bars represent mean ± SEM. One-way paired ANOVA, followed by Friedman test for multiple comparison test was performed. ns: 0.1234; *: P = 0.332; **: P = 0.0021; ***: P:0;002 or ****: P < 0.0001