Fig. 2

Recovery of motor function after stem cell transplantation in SCI. Assessment of motor function in PBS or stem cell treated mice using the BMS test: Subscore (A), BMS score (B), coordination (C), trunk (D), and the stepping score of right side (E) and left side (F). All animals in the M&N group showed significantly higher performance in the open-field BMS test than Con group (B). Significantly higher subscores were recorded for the M&N group than the Con group (A). With regard to coordination (C), in which stepping with body weight support is essential, a steady but insignificant trend toward higher performance was observed in the M&N group. Trunk function recovered earlier and to a greater extent in the M&N group than in the Con group (D). After stem cell transplantation, the M&N group showed a stable but non-significant trend of higher performance on stepping function at the early stage and from the dpo 7 onwards,showed a prominent increase (E, F). Mice limb function at dpo 1 (G, H); Mice limb function at dpo 28 (g, h). *p < 0.05; **p < 0.01