Fig. 2

Identification and functional characterization of the LRP1^high subpopulation. A–C Based on cLoupe's Graph-Based clustering (A), it can be observed that cluster 3 possesses functions related to ECM regulation and secretion of various cytokines (B). According to the DEGs of this cluster of cells, cell surface marker LRP1 were selected for sorting (C). D UMAP feature plot shows the expression level and distribution of LRP1 in three cell subtypes. E Heatmap shows differentially expressed genes of LRP1^high and LRP1^low subpopulations. F Functional enrichment analysis (GO-BP and KEGG) of LRP1 related regulatory pathways. G Functional enrichment analysis (GO-CC and GO-MF) of LRP1 related regulatory pathways