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Retraction Note: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
Stem Cell Research & Therapy volume 15, Article number: 50 (2024)
The Original Article was published on 26 October 2021
Stem Cell Research & Therapy (2021) 12:552
The authors have retracted this article. After the publication of this article, the authors carried out a voluntary and exhaustive investigation of the endothelial progenitor cells (EPC) cryovials used in this study. This investigation was performed to verify the authenticity of human cell lines as a quality control of stored biological material by Short Tandem Repeat (STR) genotyping. Unfortunately, the results of this investigation revealed that the cells used in this study were verified as hCMEC/D3 with > 95% probability using the Cellosaurus STR Similarity Search Tool, which falls within the accepted verification percentage, and not as primary cells, as expected for the endothelial progenitor cells. These results were also verified by a second external laboratory of analysis and notified to participating laboratories and to the Research Integrity Committee of the cell source laboratory.
The authors apologize to the community for this unexpected finding, which has led to the retraction of this article.
All authors agree with this retraction.
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The online version of the original article can be found at https://doi.org/10.1186/s13287-021-02608-y.
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Loiola, R.A., García-Gabilondo, M., Grayston, A. et al. Retraction Note: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage. Stem Cell Res Ther 15, 50 (2024). https://doi.org/10.1186/s13287-024-03667-7
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DOI: https://doi.org/10.1186/s13287-024-03667-7