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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Impacts of priming on distinct immunosuppressive mechanisms of mesenchymal stromal cells under translationally relevant conditions

Fig. 3

The PCA plot revealed a distinct clustering of pro-inflammatory, hypoxic, 3D culture primed, as well as unprimed MSCs from three donors. Notably, the MSCs clearly cluster by priming strategy and not by donors. The top 2000 genes ranked by standard deviation were considered for this PCA plot. The Venn diagram shows for each priming strategy, the numbers of significant DEGs (FDR ≤ 0.1, |log2 ratio| ≥ 1.5) compared to unprimed MSCs. Additionally, the Venn diagram highlights the numbers of overlapping DEGs between priming strategies to indicate similarities or dissimilarities between different priming strategies

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Stem Cell Research & Therapy

ISSN: 1757-6512