Skip to main content
Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro

Fig. 8

Model of the proposed mechanism of action of UC/PL-MSC-CM on TGF-β1-induced fibrogenic activation in HIMFs. TGF-β1 stimulates the expression of Procol1A1, FN, and α-SMA via the activation of the MRTF-A/SRF signaling and Smad2/3. UC/PL-MSC-CM counteract TGF-β1-induced fibrogenic responses by inhibiting the RhoA/MRTF-A/SRF signaling and Smad2/3 pathways

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512