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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Transcriptomic and proteomic profiles of fetal versus adult mesenchymal stromal cells and mesenchymal stromal cell-derived extracellular vesicles

Fig. 4

Comparison of the transcriptomes of fetal and adult MSCs and MSC-derived EVs. (A, B) Transcriptomics data distribution between fetal and adult MSCs. (A) Principal component analysis of fMSCs (blue dots, n = 4 donors) and aMSCs (red dots, n = 5 donors), (3 replicates from each fMSCs and aMSCs). (B) Hierarchal clustering dendrogram of fMSCs and aMSCs illustrating the distinctive donor-type specific transcriptomes. (C, D) Comparison of fetal and adult transcriptomes. Volcano plots of (C) MSCs and (D) EVs. Blue dots show significantly upregulated genes in 4 fMSCs and 3 fEVs and red dots show significantly upregulated genes in 5 aMSCs and aEVs. The coloured dots have adj-P < 0.01 and fold change > 2 (|log2 fc|>1). Black dots show detected non-significant (ns) differently expressed genes

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Stem Cell Research & Therapy

ISSN: 1757-6512